Knowledge Library

Drugging the Undruggable: Leveraging the Right Screening Methods for Challenging Targets

Challenging targets, such as membrane proteins or protein-protein interactions were considered undruggable in the past. However, today a variety of screening methods can be used to help develop drugs against these formerly undruggable targets.
Resource Type: Infographic
Resource Topic: DNA-Encoded Library (DEL) Hit Finding in silico services Mass Spectrometry-based Assays Screening Services Small Molecules Structural Biology Target Identification and Validation Targeted Protein Degradation

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WuXi AppTec in vitro Neuroscience Services

Neurological disorders, such as neurodegenerative diseases, epilepsy, chronic pain, psychiatric disorders, are one of today’s largest unmet medical needs. However, due to poor disease and target understanding, Neuroscience drug discovery can be very challenging. An open access research platform with dedicated neuroscience specialists and integrated services will be an ideal partner throughout your drug discovery …Read More >
Resource Type: Brochure
Resource Topic: Antibodies Biochemical Assays Biomarkers Cell-based Assays Cells and Protein Science Central Nervous System & Pain Hit Finding Hit-to-Lead in vitro biology Lead Optimization Phenotypic Assays Rare Diseases Safety and Early Toxicity Small Molecules Target Identification and Validation

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Discovery Newsletter November 2022
Resource Type: Latest Science Newsletter
Resource Topic: CAR-T Cell Cell-based Assays Chemical Biology and Proteomics Discovery Chemistry DRUG DISCOVERY AND INNOVATION in vitro biology Oligonucleotides Oncolytic Viruses Safety and Early Toxicity Small Molecules Target Identification and Validation Target-Specific Assays

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WuXi AppTec Discovery Services

Delivering comprehensive end-to-end solutions for creating, identifying, and supporting preclinical candidates, from discovery to development, with our integrated chemistry and biology research platform. Integrated Chemistry and Biology Research Platform | From Discovery to Candidate Selection and Beyond
Resource Type: Brochure
Resource Topic: Antibodies Antibody Drug Conjugate Autoimmune and Inflammatory Diseases Biochemical Assays Biomarkers Biophysical Assays Candidate Selection CAR-T Cell Cardiovascular & Metabolic Diseases Cell Therapies Cell-based Assays Cells and Protein Science Central Nervous System & Pain Chemical Biology and Proteomics CRISPR/Cas9 Dermatology Discovery Chemistry DNA-Encoded Library (DEL) DRUG DISCOVERY AND INNOVATION Fragment-Based Drug Discovery Gene Manipulation Gene Therapies High-throughput screening (HTS) Hit Finding Hit-to-Lead Immunology in silico services in vitro biology in vivo Pharmacology in vivo Toxicology Infectious Diseases Lead Optimization Liver Diseases Mass Spectrometry-based Assays Metabolic Diseases NASH Oligonucleotides Oncology Oncolytic Viruses Ophthalmology Phenotypic Assays Quantum Mechanics Rare Diseases Respiratory Diseases Safety and Early Toxicity Screening Libraries Screening Services Small Molecules Structural Biology Target Identification and Validation Target-Specific Assays Targeted Protein Degradation TECHNOLOGY PLATFORMS THERAPEUTIC AREAS THERAPEUTIC MODALITIES Tumor Models

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Bone metastasis platform to evaluate prophylaxis and treatment
Resource Type: Presentation
Resource Topic: in vivo Pharmacology Lead Optimization Oncology Small Molecules Target Identification and Validation

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Quality Control for DNA-Encoded One-Bead-One-Compound (OBOC) Libraries
Resource Type: Presentation Video
Resource Topic: Biochemical Assays Biophysical Assays Chemical Biology and Proteomics DNA-Encoded Library (DEL) Hit Finding in vitro biology Phenotypic Assays Screening Libraries Small Molecules Target Identification and Validation

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Integrating Practical Machine Learning and Quantum Mechanics Tools to Synthesis in Medicinal Chemistry
Resource Type: Presentation Video
Resource Topic: Chemical Biology and Proteomics Discovery Chemistry in silico services Quantum Mechanics Small Molecules

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Structure-based optimization of hydroxylactam as potent, cell-active inhibitors of lactate dehydrogenase

Structure-based design was utilized to optimize 6,6-diaryl substituted dihydropyrone and hydroxylactam to obtain inhibitors of lactate dehydrogenase (LDH) with low nanomolar biochemical and single-digit micromolar cellular potencies. Surprisingly the replacement of a phenyl with a pyridyl moiety in the chemical structure revealed a new binding mode for the inhibitors with subtle conformational change of the …Read More >
Resource Type: Publication
Resource Topic: Chemical Biology and Proteomics Discovery Chemistry Hit-to-Lead Lead Optimization Oncology Small Molecules

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Drug Discovery: Screening Approaches for Rapid Assessment of Target Tractability
Resource Type: Webinar
Resource Topic: Biophysical Assays DNA-Encoded Library (DEL) Fragment-Based Drug Discovery Hit Finding Hit-to-Lead Screening Libraries Small Molecules Target Identification and Validation Target-Specific Assays

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