Knowledge Library

Ligand Finding and Chemistry Workflows for Targeted Protein Degradation

This webinar will focus on aspects related to PROTAC discovery and chemistry workflows, such as ligand finding strategies, synthesis optimization, and linker design. Successful development of bifunctional molecules requires a deep understanding of multiple processes, including biophysical events which dictate induced proximity and how technologies such as DNA-encoded libraries (DEL) can be leveraged to identify …Read More >

Resource Type: Webinar
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Biological Characterization and Development Workflows for Targeted Protein Degradation

This webinar will focus on PROTAC biology workflows, such as in vitro screening assays, in vivo testing, and optimization of DMPK properties. Topics will include the best use of biochemical assays to measure binary/ternary complex formation, cell-based assays to assess target engagement and degradation, strategies for enhancing drug delivery and formulation, and PK/PD evaluation of …Read More >

Resource Type: Webinar
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Introduction into Fragment Based Drug Discovery

Fragment-based drug discovery (FBDD) is a method used for finding hit compounds as one strategy of hit identification in the drug discovery process. Fragments are small molecules with a low molecular weight, smaller than lead molecules or druglike molecules. The FBDD technology is based on identifying small chemical fragments, which bind to the biological target …Read More >

Resource Type: Latest Science Webinar
Resource Topic: Discovery Chemistry Fragment-Based Drug Discovery Hit Finding Hit-to-Lead Screening Libraries Small Molecules Target Identification and Validation

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Oligonucleotide Drug Development (CMC)

Recent years have seen a huge surge of interest in oligonucleotide therapeutics, fueled by major advances in our understanding of how to make such molecules stable, selective, and efficient as drug modalities. The field is now diverse in terms of therapeutic areas being addressed, biological processes being manipulated and delivery technologies employed. During this webinar …Read More >

Resource Type: Webinar
Resource Topic: Candidate Selection Oligonucleotides

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Oligonucleotide Drug Discovery

Recent years have seen a huge surge of interest in oligonucleotide therapeutics, fueled by major advances in our understanding of how to make such molecules stable, selective, and efficient as drug modalities. The field is now diverse in terms of therapeutic areas being addressed, biological processes being manipulated and delivery technologies employed. In this webinar, …Read More >

Resource Type: Webinar
Resource Topic: Biochemical Assays Cell-based Assays Discovery Chemistry Hit-to-Lead in vitro biology in vivo Pharmacology Lead Optimization Oligonucleotides Safety and Early Toxicity

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Drug Discovery: Screening Approaches for Rapid Assessment of Target Tractability

Resource Type: Webinar
Resource Topic: Biophysical Assays DNA-Encoded Library (DEL) Fragment-Based Drug Discovery Hit Finding Hit-to-Lead Screening Libraries Small Molecules Target Identification and Validation Target-Specific Assays

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CRISPR Library Screen to Identify Driver Mutations of Tumor Growth and Metastasis

Resource Type: Webinar
Resource Topic: CRISPR/Cas9 Gene Manipulation Gene Therapies Oncology Rare Diseases Screening Libraries Target Identification and Validation

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Self Service DNA Encoded Library Screening

Resource Type: Webinar
Resource Topic: Biophysical Assays DNA-Encoded Library (DEL) Hit Finding Small Molecules Target Identification and Validation

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Target to Hit Finding: New Methods in Fragment-Based Drug Discovery

Resource Type: Webinar
Resource Topic: Biochemical Assays Biophysical Assays Fragment-Based Drug Discovery Hit Finding Screening Libraries Small Molecules Target Identification and Validation Target-Specific Assays

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