Animal Models for Cardiovascular Diseases & Hematological Disorders

Cardiovascular disease models, stroke, cardiomyopathy, thrombosis, vascular, hypertension

WuXi Biology provides animal models specific for cardiovascular diseases. Our extensive portfolio of cardiovascular procedures, ranging from telemetry studies for safety evaluation, to pathophysiological models for specific diseases. WuXi Biology also possesses an extensive expertise in Hematological Disorders providing a comprehensive assessment of all aspects of cardiovascular function.


Stroke

  • Surgery biological
  • Induction

Mouse | Rat

IN VIVO PHARMACOLOGY CATALOG

CAR-A01-1Ischemic Stroke ModelMiddle cerebral artery occlusion (MCAO)
CAR-A02-1Cerebral Ischemia/Reperfusion Injury (CIRI) ModelTransient middle cerebral artery occlusion
(tMCAO)
CAR-A03-1Intracerebral Hemorrhage (ICH) ModelCollagenase intraparenchymal infusion (ICH)
CAR-A03-2Traumatic Brain Injury (TBI) ModelControlled cortical injury (CCI)
CAR-A04-1Forebrain Ischemia ModelFour-vessel occlusion (4VO)

Heart Failure

  • Coronary artery disease
  • Hypertrophic cardiomyopathy
  • Congestive heart failure
  • Atherosclerosis
  • Surgery
  • Biological induction
  • Transgenic & metabolic induction

Mouse | Rat

IN VIVO PHARMACOLOGY CATALOG

CAR-B01-1Myocardial Infarction ModelMyocardial ischemia/infarction reperfusion MI/RI
CAR-B02-1Cardiac Hypertrophy ModelTransverse aortic constriction (TAC)
CAR-B03-1Heart Failure with Preserved Ejection Fraction (HFpEF)Ang II induction
CAR-B04-1Atherosclerosis ModelDiet induction in ApoE-/- mouse

Hypertension

  • Hypertension
  • Renovascular Hypertension
  • H-type Hypertension
  • Pulmonary Arterial Hypertension
  • Chemical induction
  • Genetic model
  • Surgery
  • Physical & chemical induction

Rat

IN VIVO PHARMACOLOGY CATALOG

CAR-C01-1Hypertension Model Deoxycorticosterone acetate (DOCA) salt induction
CAR-C01-2Spontaneous HypertensionSpontaneous hypertensive rat (SHR), with renal failure
CAR-C01-3High Salt Induced Hypertension ModelSalt induction in Dahl salt-sensitive (Dahl SS) rat
CAR-C02-1Renoprival/Renovascular Hypertension Model2-kidney 1-clip (2K1C)
CAR-C03-1H-type Hypertension Model Methionine induction
CAR-C04-1Pulmonary Arterial Hypertension (PAH) ModelMonocrotaline (MCT) induction
CAR-C04-2Pulmonary Arterial Hypertension (PAH) ModelSugen 5416 and hypoxia induction

In Vivo Anti-Hypertension Service

The General Pharmacology team at WuXi Biology offers in vivo screening and testing for the pharmacological effects of anti-hypertension candidates for our clients using wireless remote systems in free moving awake animals (including rodents and large animals). Several candidates have been approved by CFDA/FDA in 2016-2017 referencing studies carried out in our laboratories.

We use DSI telemetry system in SHR, salt sensitive (DSS, DOCA) or angiotensin II-induced hypertension animals to evaluate anti-hypertension candidates.

Methods:

  • Telemetry monitoring of ECG and BP in free moving animal
  • ECG/ BP transmitters were implanted 12 days prior to dosing
  • po, sc, or iv drug administration
  • ECG and BP continuous recording for 12h post-dosing
  • Data are analyzed by DSI Ponemah package

Species: rat, dogs, NHP

Endpoint: MBP, SBP, DBP, HR, ECG

Turnaround time:  4~8weeks/study


Thrombosis

  • Arterio-Venous Shunt, rat
  • FeCl3-induced carotid artery
  • Platelet aggregation assay
  • Hemagglutination test
  • Disseminated intravascular coagulation
  • Hyperfibrinolysis
  • Surgery
  • Chemical induction
  • Genetic Model

Mouse | Rat | Rabbit

IN VIVO PHARMACOLOGY CATALOG

CAR-D01-1Thrombosis ModelArterio-venous (AV) shunt
CAR-D01-2Thrombosis ModelTail bleeding
CAR-D01-3Thrombosis ModelFeCl3 induction
CAR-D01-4Thrombosis ModelRenal vein ligation
CAR-D02-1Hemophilia Model FVIII deficient mouse

Cardiomyopathy

  • Chemical induction

Rat

IN VIVO PHARMACOLOGY CATALOG

CAR-E01-1Cardiomyopathy Model Doxorubicin (DOX) induction

Vascular Diseases

  • Surgery
  • Metablic induction

Mouse | Rat

IN VIVO PHARMACOLOGY CATALOG

CAR-F01-1Vascular DiseaseBenign Prostatic Hyperplasia (BPH)
CAR-F01-2Hindlimb IschemiaPeripheral Arterial Disease (PAD)

Case Studies

Myocardial infarction (MI) and Reperfusion Injury (IR) Model : Hemodynamics & Histopathology

Myocardial infarction and reperfusion injury models; hemodynamics and histopathology, electrocardiogram
Myocardial Infarction (MI) & Reperfusion Injury (IR) Model
(in rodents, and large animals))
Myocardial infarction and reperfusion injury models; hemodynamics and histopathology, electrocardiogram
MI: Hemodynamics & Histopathology

Transverse Aortic Constriction (TAC) Model for Pressure Overload-Induced Cardiac Hypertrophy and Heart Failure

Transverse Aortic Constriction Model Pressure Overload-Induced Cardiac Hypertrophy, Heart Failure

Learn more about our services for Cardiovascular & Metabolic Diseases Research