Animal Models for Cardiovascular Diseases & Hematological Disorders
WuXi Biology provides animal models specific for cardiovascular diseases. Our extensive portfolio of cardiovascular procedures, ranging from telemetry studies for safety evaluation, to pathophysiological models for specific diseases. WuXi Biology also possesses an extensive expertise in Hematological Disorders providing a comprehensive assessment of all aspects of cardiovascular function.
Stroke
- Surgery biological
- Induction
Mouse | Rat
IN VIVO PHARMACOLOGY CATALOG
| CAR-A01-1 | Ischemic Stroke Model | Middle cerebral artery occlusion (MCAO) |
| CAR-A02-1 | Cerebral Ischemia/Reperfusion Injury (CIRI) Model | Transient middle cerebral artery occlusion (tMCAO) |
| CAR-A03-1 | Intracerebral Hemorrhage (ICH) Model | Collagenase intraparenchymal infusion (ICH) |
| CAR-A03-2 | Traumatic Brain Injury (TBI) Model | Controlled cortical injury (CCI) |
| CAR-A04-1 | Forebrain Ischemia Model | Four-vessel occlusion (4VO) |
Heart Failure
- Coronary artery disease
- Hypertrophic cardiomyopathy
- Congestive heart failure
- Atherosclerosis
- Surgery
- Biological induction
- Transgenic & metabolic induction
Mouse | Rat
IN VIVO PHARMACOLOGY CATALOG
| CAR-B01-1 | Myocardial Infarction Model | Myocardial ischemia/infarction reperfusion MI/RI |
| CAR-B02-1 | Cardiac Hypertrophy Model | Transverse aortic constriction (TAC) |
| CAR-B03-1 | Heart Failure with Preserved Ejection Fraction (HFpEF) | Ang II induction |
| CAR-B04-1 | Atherosclerosis Model | Diet induction in ApoE-/- mouse |
Hypertension
- Hypertension
- Renovascular Hypertension
- H-type Hypertension
- Pulmonary Arterial Hypertension
- Chemical induction
- Genetic model
- Surgery
- Physical & chemical induction
Rat
IN VIVO PHARMACOLOGY CATALOG
| CAR-C01-1 | Hypertension Model | Deoxycorticosterone acetate (DOCA) salt induction |
| CAR-C01-2 | Spontaneous Hypertension | Spontaneous hypertensive rat (SHR), with renal failure |
| CAR-C01-3 | High Salt Induced Hypertension Model | Salt induction in Dahl salt-sensitive (Dahl SS) rat |
| CAR-C02-1 | Renoprival/Renovascular Hypertension Model | 2-kidney 1-clip (2K1C) |
| CAR-C03-1 | H-type Hypertension Model | Methionine induction |
| CAR-C04-1 | Pulmonary Arterial Hypertension (PAH) Model | Monocrotaline (MCT) induction |
| CAR-C04-2 | Pulmonary Arterial Hypertension (PAH) Model | Sugen 5416 and hypoxia induction |
In Vivo Anti-Hypertension Service
The General Pharmacology team at WuXi Biology offers in vivo screening and testing for the pharmacological effects of anti-hypertension candidates for our clients using wireless remote systems in free moving awake animals (including rodents and large animals). Several candidates have been approved by CFDA/FDA in 2016-2017 referencing studies carried out in our laboratories.
We use DSI telemetry system in SHR, salt sensitive (DSS, DOCA) or angiotensin II-induced hypertension animals to evaluate anti-hypertension candidates.
Methods:
- Telemetry monitoring of ECG and BP in free moving animal
- ECG/ BP transmitters were implanted 12 days prior to dosing
- po, sc, or iv drug administration
- ECG and BP continuous recording for 12h post-dosing
- Data are analyzed by DSI Ponemah package
Species: rat, dogs, NHP
Endpoint: MBP, SBP, DBP, HR, ECG
Turnaround time: 4~8weeks/study
Thrombosis
- Arterio-Venous Shunt, rat
- FeCl3-induced carotid artery
- Platelet aggregation assay
- Hemagglutination test
- Disseminated intravascular coagulation
- Hyperfibrinolysis
- Surgery
- Chemical induction
- Genetic Model
Mouse | Rat | Rabbit
IN VIVO PHARMACOLOGY CATALOG
| CAR-D01-1 | Thrombosis Model | Arterio-venous (AV) shunt |
| CAR-D01-2 | Thrombosis Model | Tail bleeding |
| CAR-D01-3 | Thrombosis Model | FeCl3 induction |
| CAR-D01-4 | Thrombosis Model | Renal vein ligation |
| CAR-D02-1 | Hemophilia Model | FVIII deficient mouse |
Cardiomyopathy
- Chemical induction
Rat
IN VIVO PHARMACOLOGY CATALOG
| CAR-E01-1 | Cardiomyopathy Model | Doxorubicin (DOX) induction |
Vascular Diseases
- Surgery
- Metablic induction
Mouse | Rat
IN VIVO PHARMACOLOGY CATALOG
| CAR-F01-1 | Vascular Disease | Benign Prostatic Hyperplasia (BPH) |
| CAR-F01-2 | Hindlimb Ischemia | Peripheral Arterial Disease (PAD) |
Case Studies
Myocardial infarction (MI) and Reperfusion Injury (IR) Model : Hemodynamics & Histopathology
(in rodents, and large animals))
Transverse Aortic Constriction (TAC) Model for Pressure Overload-Induced Cardiac Hypertrophy and Heart Failure
