Animal Models for Cardiovascular Diseases & Hematological Disorders

WuXi Biology provides animal models specific for cardiovascular diseases. Our extensive portfolio of cardiovascular procedures, ranging from telemetry studies for safety evaluation, to pathophysiological models for specific diseases. WuXi Biology also possesses an extensive expertise in Hematological Disorders providing a comprehensive assessment of all aspects of cardiovascular function.

Heart Failure

  • Myocardial infarction (MI) reperfusion injury (IR) models in rodents and large animals
  • Transverse Aortic Constriction (TAC) induced, mouse
  • Angiotensin II-induced heart failure with preserved ejection fraction (HFpEF), mouse

Pulmonary Artery Hypertension

  • Monocrotaline(MCT) induced PAH, rat

Atherosclerosis

  • Diet induced atherosclerosis in ApoE/-mouse

Thrombosis & Tests

  • Arterio-Venous Shunt, rat
  • FeCl3-induced carotid artery thrombosis, rat
  • FeCl3-induced carotid artery thrombosis, rat
  • Platelet aggregation assay, rodent & large animals
  • Hemagglutination test, rodent & large animals
  • Disseminated intravascular coagulation, rabbit
  • Hyperfibrinolysis, rat

In Vivo Anti-Hypertension Service

The General Pharmacology team at WuXi Biology offers in vivo screening and testing for the pharmacological effects of anti-hypertension candidates for our clients using wireless remote systems in free moving awake animals (including rodents and large animals). Several candidates have been approved by CFDA/FDA in 2016-2017 referencing studies carried out in our laboratories.

Introduction: Use DSI telemetry system in SHR, salt sensitive (DSS, DOCA) or angiotensin II-induced hypertension animals to evaluate anti-hypertension candidates

Species: rat, dogs, NHP

Endpoint: MBP, SBP, DBP, HR, ECG

Turnaround time:  4~8weeks/study


Case Studies

Myocardial infarction (MI) and Reperfusion Injury (IR) Model : Hemodynamics & Histopathology

Myocardial Infarction (MI) & Reperfusion Injury (IR) Model
(in rodents, and large animals))
MI: Hemodynamics & Histopathology

Transverse Aortic Constriction (TAC) Model for Pressure Overload-Induced Cardiac Hypertrophy and Heart Failure

Learn more about our services for Cardiovascular & Metabolic Diseases Research