What is DEL?
DNA-Encoded Library (DEL) technology involves a novel affinity selection process that integrates chemistry, biology, bioinformatics and computational chemistry to facilitate a rapid drug discovery process, allowing access to more chemical space with lower cost.
In contrast to high throughput screening, DEL requires a very small amount of target protein and minimum assay development. More importantly, it disrupts the concept of “cost-per-well” and allows testing billions of compounds in one tube.
Why Our Library is an Ideal Choice for DEL Screening
Library Production Service
- 80+ billion synthetic compounds for diversity
- 100+ selective hot cores for latent druggability of compounds
- 35,000+ commercially source building blocks in stock
- Unique multiple on-DNA reactions to build various chemical bonds
- Flexible library construction to accommodate clients’ needs
- Robust and strict quality to control procedures
- Our extended platform enables overall planning and management of protein production, DEL library production, affinity selection, data analysis, hit validation and structural biology for further optimization.
- View our DDC 2023 Presentation: “DNA-Encoded Libraries for the Discovery of Small-Molecule Hits”
Check out our One-Stop Target-to-Hit Solutions platform
3 Types of Services Designed for Different Needs
Free access to DEL data sharing
4.4
Billions
Target confidentiality for academics users | Open source
Unprecedented data release
15.1
Billions
Target confidentiality for all drug developers | Easy access with reduced risk
One-stop solution customizable
46+
Billions
Target exclusivity for all drug developers | Access to unique scaffolds
More than Conventional DEL Screening
Irreversible Covalent Screening
- Specially designed library collection with electrophilic warheads
- Optimized selection method to enhance the signal-to-noise ratio
RNA as a Target
- Optimized selection procedure to counter charge, RNA/DNA interaction and structural integrity of RNA during DEL screen
- DDC 2023 Presentation: “Discovery of RNA Targeting Small Molecules – Our Toolbox for RNA Drug Discovery”
DEL & Machine Learning
- Ligand-based virtual screening; Lead-like chemical space
- Cost-effective compound acquisition
- Case study: DEL data combined with in silico deep-learning model
What screening methods can be chosen in WuXi AppTec HitS?
Conventional screening
- Well-established method
- Suits a wide variety of targets
- Screening conditions can be designed to achieve the objective
Covalent library screening
In search of irreversible binders for various targets through permanent linkage.
Target RNA
To identify RNA binding molecules targeting disease-associated RNAs through DEL screening technology.
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