DNA-Encoded Library (DEL) Services

DEL Molecule

Fast Screening of Billions of Small Molecule Compounds

DNA-Encoded Library (DEL) technology involves a novel affinity selection process that integrates chemistry, biology, bioinformatics and computational chemistry to facilitate a rapid drug discovery process, allowing access to more chemical space with lower cost.

In contrast to high throughput screening, DEL requires a very small amount of target protein and minimum assay development. More importantly, it disrupts the concept of “cost-per-well” and allows testing billions of compounds in one tube.


3 Types of Services Designed for Different Needs

Free access to DEL data sharing

4.4

Billions

Target confidentiality for academics users | Open source

Unprecedented data release

15.1

Billions

Target confidentiality for all drug developers | Easy access with reduced risk

One-stop solution customizable

46+

Billions

Target exclusivity for all drug developers | Access to unique scaffolds


Why Our Library is an Ideal Choice for DEL Screening

DEL Library production

Library Production Service

  • 80+ billion synthetic compounds for diversity
  • 100+ selective hot cores for latent druggability of compounds
  • 35,000+ commercially source building blocks in stock
  • Unique multiple on-DNA reactions to build various chemical bonds
  • Flexible library construction to accommodate clients’ needs
  • Robust and strict quality to control procedures

Our extended platform enables overall planning and management of protein production, DEL library production, affinity selection, data analysis, hit validation and structural biology for further optimization.

New Modalities

Irreversible Covalent Modification

Peptide Discovery

RNA as a Target

DEL page covalent column
DEL page peptide column
DEL page RNA column

*Currently, WuXi AppTec does not provide bacteriophage display, mRNA display, or ribosomal display-based screening services for bicyclic peptides constrained on a molecular scaffold. WuXi AppTec does provide a variety of DNA-Encoded Library (DEL) screening services.


Screening Methods | More than Conventional DEL Screening

Unique, multiple on-DNA reactions to build a diversity of chemical bonds, parallel screening against targets

Conventional screening

  • Well-established method
  • Suits a wide variety of targets
  • Screening conditions can be designed to achieve the objective
More than 70 libraries for screening covalent inhibitor hits, irreversible binding, binders

Covalent library screening

In search of irreversible binders for various targets through permanent linkage.

Electrostatic repulsion between RNA and DNA, interactions, hybridization, Structural integrity, target

Target RNA

To identify RNA binding molecules targeting disease-associated RNAs through DEL screening technology.

Contact our Experts to discuss your early discovery projects

Learn more about our Target-to-Hit Platform


Related Resources View All

DNA-Compatible Huisgen Cycloaddition

Resource Type: Latest Science Publication

On-bead DEL Application and Case Study for Drug Discovery

Resource Type: Latest Science Poster

Accelerating CIP Discovery with ASMS and DEL

Resource Type: Latest Science Poster

Discovery of a Novel Covalent Inhibitor Using DEL

Resource Type: Latest Science Poster

DEL Screening to Discover Small Molecule Ligands for RNA

Resource Type: Latest Science Publication

Discovery of a Selective BET Inhibitor for Treating Osteoarthritis

Resource Type: Latest Science Publication