What is DEL?
DNA-Encoded Library (DEL) technology involves a novel affinity selection process that integrates chemistry, biology, bioinformatics and computational chemistry to facilitate a rapid drug discovery process, allowing access to more chemical space with lower cost.
In contrast to high throughput screening, DEL requires a very small amount of target protein and minimum assay development. More importantly, it disrupts the concept of “cost-per-well” and allows testing billions of compounds in one tube.
Why Our Library is an Ideal Choice for DEL Screening
Library Production Service
- 80+ billion synthetic compounds for diversity
- 100+ selective hot cores for latent druggability of compounds
- 35,000+ commercially source building blocks in stock
- Unique multiple on-DNA reactions to build various chemical bonds
- Flexible library construction to accommodate clients’ needs
- Robust and strict quality to control procedures
- Our extended platform enables overall planning and management of protein production, DEL library production, affinity selection, data analysis, hit validation and structural biology for further optimization.
- View our DDC 2023 Presentation: “DNA-Encoded Libraries for the Discovery of Small-Molecule Hits”
- View our publication: “DELs enable the development of BRET probes for target engagement studies in cells”
Check out our One-Stop Target-to-Hit Solutions platform
3 Types of Services Designed for Different Needs
Free access to DEL data sharing
4.4
Billions
Target confidentiality for academics users | Open source
Unprecedented data release
15.1
Billions
Target confidentiality for all drug developers | Easy access with reduced risk
One-stop solution customizable
46+
Billions
Target exclusivity for all drug developers | Access to unique scaffolds
More than Conventional DEL Screening
Irreversible Covalent Screening
- Specially designed library collection with electrophilic warheads
- Optimized selection method to enhance the signal-to-noise ratio
RNA as a Target
- Optimized selection procedure to counter charge, RNA/DNA interaction and structural integrity of RNA during DEL screen
- DDC 2023 Presentation: “Discovery of RNA Targeting Small Molecules – Our Toolbox for RNA Drug Discovery”
DEL & Machine Learning
- Ligand-based virtual screening; Lead-like chemical space
- Cost-effective compound acquisition
- Case study: DEL data combined with in silico deep-learning model
What screening methods can be chosen in WuXi AppTec HitS?
Conventional screening
- Well-established method
- Suits a wide variety of targets
- Screening conditions can be designed to achieve the objective
Covalent library screening
In search of irreversible binders for various targets through permanent linkage.
Target RNA
To identify RNA binding molecules targeting disease-associated RNAs through DEL screening technology.
Related Resources View All
Recent Advances in Peptide Drug Discovery
Resource Type: Webinar
Screening Methods to Identify RNA-Targeting Small Molecules
Resource Type: Webinar
Discovery of Novel GST Inhibitors Identified from a DNA-Encoded Library
Resource Type: Latest Science Publication
DELvision: Improving Data-Driven Drug Discovery
Resource Type: Article
DELs enable the development of BRET probes for target engagement...
Resource Type: Latest Science Publication
DNA-Encoded Macrocyclic Peptide Libraries Enable the Discovery of a Neutral...
Resource Type: Latest Science Publication
Discovery of RNA Targeting Small Molecules - Our Toolbox for...
Resource Type: Presentation Video
DNA-Encoded Libraries for the Discovery of Small-Molecule Hits
Resource Type: Presentation Video
DNA-Encoded Libraries: DELight Handbook
Resource Type: Brochure
DNA-Encoded Libraries: DELight User Manual
Resource Type: Brochure
DNA-Encoded Libraries: DELight Flyer
Resource Type: Brochure Latest Science
Case Study: DEL Data Combined with In Silico Deep-Learning Model
Resource Type: Case Study Latest Science
DNA-Encoded Libraries: DELopen Handbook
Resource Type: Brochure
DNA-Encoded Libraries: DELopen User Manual
Resource Type: Brochure
DNA Encoded Libraries: DELopen Flyer
Resource Type: Brochure
Discovery and Structural Characterization of Small Molecule Binders of the...
Resource Type: Latest Science Publication
Ligand Finding and Chemistry Workflows for Targeted Protein Degradation
Resource Type: Webinar
DNA-encoded chemical libraries
Resource Type: Publication
Drugging the Undruggable: Leveraging the Right Screening Methods for Challenging...
Resource Type: Infographic
WuXi AppTec Discovery Services
Resource Type: Brochure
Quality Control for DNA-Encoded One-Bead-One-Compound (OBOC) Libraries
Resource Type: Presentation Video
Discovery of RNA Targeting Small Molecule Using DNA-Encoded Library Technology
Resource Type: Presentation Video
Drug Discovery: Screening Approaches for Rapid Assessment of Target Tractability
Resource Type: Webinar
Optimizing Drug Pipelines With Biophysical Methods
Resource Type: White Paper
One-Stop Target-to-Hit Solutions
Resource Type: Brochure
DELpro: A New Method of Hit Discovery
Resource Type: Brochure
Self Service DNA Encoded Library Screening
Resource Type: Webinar
DNA-Encoded Libraries in Drug Discovery - Advances in Screening and...
Resource Type: Presentation Video
Introduction to Self-Service DNA-Encoded libraries (DELs)
Resource Type: Webinar
Enabling Drug Discovery with Diverse Lead Generation Platforms
Resource Type: Webinar
Optimizing Drug Discovery Pipelines with Biophysical Methods
Resource Type: Webinar
Discovery of RNA binding molecule using DNA-encoded library technology
Resource Type: Webinar
Unlocking the potential of DEL | Inspire Hit Discovery
Resource Type: Article
One-stop DEL services from target to hit series - DELpro
Resource Type: Brochure
Open Access to DEL for data sharing - DELopen
Resource Type: Brochure
DNA-encoded libraries for academic - DELopen Handbook
Resource Type: Brochure
DEL Screening - DELight Handbook
Resource Type: Brochure
