What is DEL?

DNA-Encoded Library (DEL) technology involves a novel affinity selection process that integrates chemistry, biology, bioinformatics and computational chemistry to facilitate a rapid drug discovery process, allowing access to more chemical space with lower cost.

In contrast to high throughput screening, DEL requires a very small amount of target protein and minimum assay development. More importantly, it disrupts the concept of “cost-per-well” and allows testing billions of compounds in one tube.

DEL Molecule

Why Our Library is an Ideal Choice for DEL Screening

Library Production Service

  • 80+ billion synthetic compounds for diversity
  • 100+ selective hot cores for latent druggability of compounds
  • 35,000+ commercially source building blocks in stock
  • Unique multiple on-DNA reactions to build various chemical bonds
  • Flexible library construction to accommodate clients’ needs
  • Robust and strict quality to control procedures
  • Our extended platform enables overall planning and management of protein production, DEL library production, affinity selection, data analysis, hit validation and structural biology for further optimization.
  • View our DDC 2023 Presentation: “DNA-Encoded Libraries for the Discovery of Small-Molecule Hits”
  • View our publication: “DELs enable the development of BRET probes for target engagement studies in cells”
DEL Library production

Check out our One-Stop Target-to-Hit Solutions platform

3 Types of Services Designed for Different Needs

Free access to DEL data sharing



Target confidentiality for academics users | Open source

Unprecedented data release



Target confidentiality for all drug developers | Easy access with reduced risk

One-stop solution customizable



Target exclusivity for all drug developers | Access to unique scaffolds

More than Conventional DEL Screening

Irreversible Covalent Screening

  • Specially designed library collection with electrophilic warheads
  • Optimized selection method to enhance the signal-to-noise ratio
irreversible covalent screening, electrophilic warheads

RNA as a Target

  • Optimized selection procedure to counter charge, RNA/DNA interaction and structural integrity of RNA during DEL screen
  • DDC 2023 Presentation: “Discovery of RNA Targeting Small Molecules – Our Toolbox for RNA Drug Discovery”
RNA as a drug target, parallel screening, DEL, target, hit ID

DEL & Machine Learning

Machine Learning, artificial intelligence, parallel screening, small molecules, lead-like chemical space

What screening methods can be chosen in WuXi AppTec HitS?

Unique, multiple on-DNA reactions to build a diversity of chemical bonds, parallel screening against targets

Conventional screening

  • Well-established method
  • Suits a wide variety of targets
  • Screening conditions can be designed to achieve the objective
More than 70 libraries for screening covalent inhibitor hits, irreversible binding, binders

Covalent library screening

In search of irreversible binders for various targets through permanent linkage.

Electrostatic repulsion between RNA and DNA, interactions, hybridization, Structural integrity, target

Target RNA

To identify RNA binding molecules targeting disease-associated RNAs through DEL screening technology.

Related Resources View All

DNA-Encoded Libraries: DELight Handbook

Resource Type: Brochure

DNA-Encoded Libraries: DELight Flyer

Resource Type: Brochure Latest Science

Case Study: DEL Data Combined with In Silico Deep-Learning Model

Resource Type: Case Study Latest Science

DNA-Encoded Libraries: DELopen Handbook

Resource Type: Brochure

DNA Encoded Libraries: DELopen Flyer

Resource Type: Brochure

DNA-encoded chemical libraries

Resource Type: Publication

WuXi AppTec Discovery Services

Resource Type: Brochure

One-Stop Target-to-Hit Solutions

Resource Type: Brochure

DELpro: A New Method of Hit Discovery

Resource Type: Brochure

DEL Screening - DELight Handbook

Resource Type: Brochure