DNA-Encoded Library (DEL) Services

DEL Molecule

Fast Screening of Billions of Small Molecule Compounds

DNA-Encoded Library (DEL) technology involves a novel affinity selection process that integrates chemistry, biology, bioinformatics and computational chemistry to facilitate a rapid drug discovery process, allowing access to more chemical space with lower cost.

In contrast to high throughput screening, DEL requires a very small amount of target protein and minimum assay development. More importantly, it disrupts the concept of “cost-per-well” and allows testing billions of compounds in one tube.


3 Types of Services Designed for Different Needs

Free access to DEL data sharing

4.4

Billions

Target confidentiality for academics users | Open source

Unprecedented data release

15.1

Billions

Target confidentiality for all drug developers | Easy access with reduced risk

One-stop solution customizable

46+

Billions

Target exclusivity for all drug developers | Access to unique scaffolds


Why Our Library is an Ideal Choice for DEL Screening

DEL Library production

Library Production Service

  • 80+ billion synthetic compounds for diversity
  • 100+ selective hot cores for latent druggability of compounds
  • 35,000+ commercially source building blocks in stock
  • Unique multiple on-DNA reactions to build various chemical bonds
  • Flexible library construction to accommodate clients’ needs
  • Robust and strict quality to control procedures

Our extended platform enables overall planning and management of protein production, DEL library production, affinity selection, data analysis, hit validation and structural biology for further optimization.


New Modalities

Irreversible Covalent Screening

  • Specially designed library collection with electrophilic warheads
  • Optimized selection method to enhance the signal-to-noise ratio
irreversible covalent screening, electrophilic warheads

RNA as a Target

  • Optimized selection procedure to counter charge, RNA/DNA interaction and structural integrity of RNA during DEL screen
  • DDC 2023 Presentation: “Discovery of RNA Targeting Small Molecules – Our Toolbox for RNA Drug Discovery”
RNA as a drug target, parallel screening, DEL, target, hit ID

DEL & Machine Learning

Machine Learning, artificial intelligence, parallel screening, small molecules, lead-like chemical space

Screening Methods | More than Conventional DEL Screening

Unique, multiple on-DNA reactions to build a diversity of chemical bonds, parallel screening against targets

Conventional screening

  • Well-established method
  • Suits a wide variety of targets
  • Screening conditions can be designed to achieve the objective
More than 70 libraries for screening covalent inhibitor hits, irreversible binding, binders

Covalent library screening

In search of irreversible binders for various targets through permanent linkage.

Electrostatic repulsion between RNA and DNA, interactions, hybridization, Structural integrity, target

Target RNA

To identify RNA binding molecules targeting disease-associated RNAs through DEL screening technology.

Contact our Experts to discuss your early discovery projects

Learn more about our Target-to-Hit Platform


Related Resources View All

In Silico Drug Discovery Platform

Resource Type: Brochure

Creating a Biological Switch Using DEL Technology

Resource Type: Latest Science Poster

DEL Empowers Discovery of Peptide Drugs

Resource Type: Latest Science Poster

Integrated Screening in Hit Identification

Resource Type: Latest Science Poster

Heme Oxygenase-1-Targeting Molecules

Resource Type: Latest Science Publication