Knowledge Library

Atopic Dermatitis Models

Atopic dermatitis (AD) is the most common, chronic inflammatory skin disease.  To support drug discovery research in this area, WuXi AppTec offers a broad platform of validated, in vivo AD models.  Our panel includes DNCB, DNFB, and MC903-induced AD models.  Study readouts include histopathology scoring and measurements of serum IgE levels, transepidermal water loss, and …Read More >

Resource Type: Latest Science Presentation
Resource Topic: Autoimmune and Inflammatory Diseases in vivo Pharmacology

VIEW

Metastasis-Related In Vitro Assays and Xenograft Models

Cell migration, invasion, and adhesion are pivotal steps in cancer metastasis.  To support research in this field, WuXi AppTec offers in vitro transwell migration and invasion assays using multiple cell types for assessing cell migratory behavior.  In addition, our in vivo metastasis panel includes a broad range of brain, bone, and liver xenograft models covering …Read More >

Resource Type: Latest Science Presentation
Resource Topic: Cell-based Assays Oncology Tumor Models

VIEW

Jurkat Reporter Cell Lines for Immunotherapy Drug Screening

WuXi AppTec offers Jurkat reporter cell lines for immunotherapy drug screening.  Our platform includes CD8+, TCR knockout and CD16-expressing Jurkat-NFAT-Luc reporter cell lines, and validated assays (using co-cultures of Raji or A375 tumor cells) to evaluate the activity of CARs, TCRs, and bispecific antibodies.  Leverage our portfolio of reporter cell lines to accelerate your research! …Read More >

Resource Type: Latest Science Presentation
Resource Topic: Cell-based Assays Cells and Protein Science Immunology Oncology

VIEW

Discovery of Novel GST Inhibitors Identified from a DNA-Encoded Library

WuXi AppTec scientists recently contributed to a study which led to the discovery and optimization of a novel series of GST inhibitors. The authors used affinity mediated DEL selection against a privileged scaffold to identify a compound with potent inhibition against SjGST and GSTM2. SAR studies, coupled with X-ray crystallography and structural analysis, revealed that …Read More >

Resource Type: Latest Science Publication
Resource Topic: Biochemical Assays DNA-Encoded Library (DEL) Hit Finding Hit-to-Lead Lead Optimization Small Molecules Structural Biology

VIEW

Discovery and Characterization of Proteolysis Targeting Chimeras: Tissue Transglutaminase

Tissue transglutaminase (TG2) is a multifunctional enzyme activated in several pathological conditions, including cancer. WuXi AppTec recently contributed to a study which used a targeted protein degradation strategy to abolish TG2’s myriad of functions. The authors synthesized and characterized a series of VHL-based degraders that reduce TG2 in ovarian cancer cells in a proteasome-dependent manner.

Resource Type: Latest Science Publication
Resource Topic: Oncology Targeted Protein Degradation

VIEW

Emerging Modalities in Drug Discovery

In this webinar, we present the latest advances and challenges facing researchers focused on new and emerging modalities in drug discovery. Topics include targeted protein degradation, targeted covalent inhibitors, and nucleic acid therapeutics. Our expert speaker, Dr. Tao Guo, discusses solutions for addressing the complexities in designing, synthesizing, and optimizing these molecules, with an added …Read More >

Resource Type: Latest Science Webinar
Resource Topic: Discovery Chemistry Oligonucleotides Small Molecules Targeted Protein Degradation

VIEW

Oligonucleotide Therapeutics: Drug Discovery Through Tightly Coupled Chemistry and Biology

Designing effective oligonucleotide therapeutics for clinical applications involves understanding both the chemistry and biology of nucleic acids. In this white paper, learn about recent advances in chemical modifications for oligonucleotide therapeutics that improve stability and selectivity, biological screening assays to support lead optimization, and bioanalytical platforms that address the challenges of quantifying oligonucleotides. Check out …Read More >

Resource Type: Latest Science White Paper
Resource Topic: Oligonucleotides

VIEW

Alopecia Mouse Models

Our in vivo alopecia platform is comprised of both non-cicatricial and cicatricial alopecia models, including skin graft-induced alopecia areata (AA) in C3H/HeJ mice, cyclophosphamide-induced alopecia in C57BL/6 mice, and androgenetic alopecia (AGA) in C57BL/6 mice. Discover our comprehensive panel of in vivo pharmacology models by clicking here

Resource Type: Latest Science Presentation
Resource Topic: Autoimmune and Inflammatory Diseases in vivo Pharmacology

VIEW

New study by Promega and WuXi AppTec demonstrates novel chemical probes from DELs

As reported in Business Wire: DNA-Encoded Libraries (DELs) and NanoBRET Target Engagement Assays Accelerate Drug Discovery: “The authors demonstrate that DELs can benefit chemical biologists who require verification of live cell target engagement for their protein of interest. This is particularly beneficial for understudied protein classes that may not have existing chemical probes. Additionally, they …Read More >

Resource Type: Article Latest Science Newsletter
Resource Topic: Cell-based Assays DNA-Encoded Library (DEL) Hit Finding Hit-to-Lead

VIEW


Resource Topics
× peptide, amino acid

Contact An Expert Today!