Knowledge Library

Discovery of RNA Targeting Small Molecules – Our Toolbox for RNA Drug Discovery

Drug Discovery Chemistry Conference 2023 WuXi AppTec has developed technologies to facilitate RNA small molecule screening, an exciting frontier in drug discovery. SHAPE-MaP is applied to determine RNA structure and dynamics and verify small molecule binding. We utilize the “DNA-Zipper” strategy to enable DNA-encoded libraries to identify RNA binders. With other technologies including fragment-based drug …Read More >
Resource Type: Presentation Video
Resource Topic: Biophysical Assays DNA-Encoded Library (DEL) Fragment-Based Drug Discovery Hit Finding Hit-to-Lead Mass Spectrometry-based Assays Oligonucleotides Small Molecules

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Biophysical and Structural Biology Methods Enable Fragment-based Covalent Ligand Discovery of Human BTK

Drug Discovery Chemistry Conference 2023 Powerful biophysical and structural biology tools enable the study of large numbers of covalent fragments and are opening up new possibilities in the treatment of various diseases. Here, Dr. Moran Jerabek-Willemsen, Head of Biophysics & Screening in WuXi Biology reports the results of a covalent FBDD project on Bruton’s Tyrosine …Read More >
Resource Type: Presentation Video
Resource Topic: Biochemical Assays Biophysical Assays Discovery Chemistry Fragment-Based Drug Discovery Hit-to-Lead Lead Optimization Mass Spectrometry-based Assays Screening Libraries Small Molecules Structural Biology

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DNA-Encoded Libraries for the Discovery of Small-Molecule Hits

Drug Discovery Chemistry Conference 2023 DNA-Encoded library (DEL) screening is now commonly used in the pharmaceutical industry to find novel chemical matter that modulates protein targets of interest.  Point-by-point, Dr. Alex Satz, Executive Director, WuXi Biology will discuss the primary challenges and limitations of DEL screening, and concisely state the current abilities of the technology …Read More >
Resource Type: Presentation Video
Resource Topic: DNA-Encoded Library (DEL) Hit Finding in silico services Screening Services Small Molecules

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DNA-Encoded Libraries: DELight Handbook
Resource Type: Brochure
Resource Topic: DNA-Encoded Library (DEL) Hit Finding Screening Services Small Molecules

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DNA-Encoded Libraries: DELight User Manual
Resource Type: Brochure
Resource Topic: DNA-Encoded Library (DEL) Hit Finding Screening Services Small Molecules

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DNA-Encoded Libraries: DELight Flyer
Resource Type: Brochure Latest Science
Resource Topic: DNA-Encoded Library (DEL) Hit Finding Screening Services Small Molecules

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Discovery of Potent and Selective Dual Leucine Zipper Kinase/Leucine Zipper-Bearing Kinase Inhibitors

Dual leucine zipper kinase (DLK) and leucine zipper-bearing kinase (LZK) have emerged as key regulators of neuronal degeneration and axon growth.  WuXi AppTec scientists recently contributed to a research article in the Journal of Medicinal Chemistry demonstrating the use of ligand- and structure-based drug design approaches to discover an amino-pyrazine chemical series of DLK and …Read More >
Resource Type: Latest Science Publication
Resource Topic: Biochemical Assays Biomarkers Central Nervous System & Pain Discovery Chemistry Lead Optimization Small Molecules

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DNA-Encoded Libraries: DELopen Handbook
Resource Type: Brochure
Resource Topic: DNA-Encoded Library (DEL) Hit Finding Screening Services Small Molecules

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DNA-Encoded Libraries: DELopen User Manual
Resource Type: Brochure
Resource Topic: DNA-Encoded Library (DEL) Hit Finding Screening Services Small Molecules

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