Preclinical Pharmacology

WuXi Biology offers in integrated services with in vitro biology, DMPK and toxicology studies to provide datasets and evidence for IND-enabling.

Large and expanding infrastructure

  • AAALAC-accredited animal facility
  • IVC-cages capacity in SPF barrier

Growing number of available animal models

  • 1000+ tumor models / 1300+ PDX models / 280+ CDX models
  • Gene KO/KI animals

Exploration in new technologies including patient-derived organoids and single cell RNAseq etc..

We offer Pharmacokinetic studies and ADME (stabilities, plasma protein binding, transporter, tissue distribution, metabolic ID, excretion), safety and efficacy studies with both in vitro and in vivo models.

Safety

  • In vitro assays
    • Protein/enzyme activity, induction & inhibition
    • Transferase assays
    • Cellular toxicity
    • Genetic toxicity
  • In vivo toxicity
    • Toxicokinetics (TK)
    • Systemic & specific tox
    • Short & long term tox
    • Clinical relevance (dose, dose escalation, etc.)
    • Clinical safety

Efficacy

  • Benchmark, selection
    • Animal efficacy test
    • Animal model of clinical relevance, sufficiency
    • Target engagement
    • PD profiling
    • Biomarkers
  • PK/PD study / PK parameters for efficacy
  • Mechanistic pharmacology
    • Gene expression profiling
    • omics studies
    • Disease mechanism

PK / ADME

  • Benchmark, selection
  • PK
    • Standard PK
    • PK parameters for efficacy
    • Dosing regimen design
  • ADME
    • Stabilities
    • Plasma protein binding
    • Transporter
    • Tissue distribution
    • Metabolic ID
    • Excretion

Diseases Areas

Cardiovascular & Metabolic Diseases

Heart failure & stroke | Hypertension | AF | Obesity & diabetes | NASH |Kidney failure | Hyperuricemia

Infectious Diseases

A comprehensive virology platform to support lead ID/Op, SAR, PCC | HDI | AAV/HBV | HBV | RSV | Influenza

Oncology & Immuno-oncology

All major cancer types

Neurosciences

Parkinson’s | Alzheimer’s | Pain | Epilepsy/seizure | Brain stroke | TBI

Respiratory Diseases

COPD | Asthma | PAH | Obstructive sleep apnea hypopnea syndrome

Immunology and inflammation

Rheumatoid arthritis | IBD | MS | SLE | Psoriasis | ACD

Liver, Lung, Kidney, GI Diseases

Lung Fibrosis | ALI | Nephropathy | Acute kidney injuries | kidney fibrosis | Gastric ulcer | IBS