WuXi Biology offers in integrated services with in vitro biology, DMPK and toxicology studies to provide datasets and evidence for IND-enabling.
Large and expanding infrastructure
- AAALAC-accredited animal facility
- IVC-cages capacity in SPF barrier
Growing number of available animal models
- 1000+ tumor models / 1300+ PDX models / 280+ CDX models
- Gene KO/KI animals
Exploration in new technologies including patient-derived organoids and single cell RNAseq etc..
We offer Pharmacokinetic studies and ADME (stabilities, plasma protein binding, transporter, tissue distribution, metabolic ID, excretion), safety and efficacy studies with both in vitro and in vivo models.
- Benchmark, selection
- Animal efficacy test
- Animal model of clinical relevance, sufficiency
- Target engagement
- PD profiling
- PK/PD study / PK parameters for efficacy
- Mechanistic pharmacology
- Gene expression profiling
- omics studies
- Disease mechanism
Heart failure & stroke | Hypertension | AF | Obesity & diabetes | NASH |Kidney failure | Hyperuricemia
A comprehensive virology platform to support lead ID/Op, SAR, PCC | HDI | AAV/HBV | HBV | RSV | Influenza
All major cancer types
Parkinson’s | Alzheimer’s | Pain | Epilepsy/seizure | Brain stroke | TBI