Knowledge Library

One-stop DEL services from target to hit series – DELpro

WuXi AppTec  provides a one-stop solution for DEL services from target to hit series. Our extended platform enables overall planning and management of protein production, DEL library production, affinity selection, data analysis, hit validation and structural biology for further optimization.

Resource Type: Brochure
Resource Topic: Biophysical Assays Cells and Protein Science Discovery Chemistry DNA-Encoded Library (DEL) Hit Finding Hit-to-Lead Small Molecules Target Identification and Validation

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Open Access to DEL for data sharing – DELopen

DELopen platform is dedicated to the development and application of DEL technology in drug discovery. Free access to DEL, data sharing. DELopen encourages an open, community-based approach to data sharing and exploration of the capabilities of DEL technology. We envision that DELopen will help academia benefits from the efficiency of DEL and unlock the full …Read More >

Resource Type: Brochure
Resource Topic: Discovery Chemistry DNA-Encoded Library (DEL) Hit Finding Screening Libraries Small Molecules Target Identification and Validation

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DNA-encoded libraries for academic – DELopen Handbook

DNA-encoded libraries for academic | Open Access to DEL Self-service platform for academia to utilize the full potential of DEL technology DELopen provides free access to DNA-encoded libraries (DEL) for academic users and encourages an open, community-based approach to data sharing.

Resource Type: Brochure
Resource Topic: Discovery Chemistry DNA-Encoded Library (DEL) Hit Finding Screening Libraries Small Molecules Target Identification and Validation

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DEL Screening – DELight Handbook

DEL Screening | WuXi AppTec DELight Kit  Faster and Lighter Drug Discovery DELight kit containing 58 libraries and 10.8 billion compounds, buffers and a step-by-step online experimental manual. Drug developers perform affinity selection according to the manual and return the sample to WuXi AppTec upon completion.

Resource Type: Brochure
Resource Topic: Chemical Biology and Proteomics DNA-Encoded Library (DEL) Hit Finding Screening Libraries Small Molecules Target Identification and Validation Targeted Protein Degradation

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Discovery Chemistry Outsourcing Services

Global Leader in Discovery Chemistry Outsourcing Services Based on FTE (Full Time Equivalent) Model | Customization to Client’s Synthetic Chemistry with high productivity, quality, speed, and reliability Project Management:  we manage project timelines and compound flow Medicinal Chemistry: we provide compound design and project management Integrated Projects from targets to hits to leads to preclinical …Read More >

Resource Type: Brochure
Resource Topic: Candidate Selection Chemical Biology and Proteomics Discovery Chemistry Hit-to-Lead Lead Optimization Mass Spectrometry-based Assays Quantum Mechanics Small Molecules

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Cell Line-Derived Xenograft (CDX) Tumor Models

A large collection of cell line-derived xenograft (CDX) tumor models 215 validated models, SOC data available World leading imaging based orthotopic/metastatic CDX platform 28 models covering 16 tumor types

Resource Type: Brochure
Resource Topic: in vivo Pharmacology Lead Optimization Oncology Oncolytic Viruses Small Molecules Target Identification and Validation Tumor Models

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WuXi Oncology and Immuno-Oncology Services

Integrated Oncology and Immuno-oncology Platform to Enable Translational Science from Drug Discovery to Clinical Biomarker Oncology Services CRISPR/Cas9 Gene Editing In Vitro Assay and HTS Tumor models Tumor Cell Panel and Screening Immunology and Immuno-oncology Platform Clinical Biomarker Immunology Services Ligand-receptor binding assays Cellular functional assays Assays for innate immunity pathways: macrophage, MDSC, NK, DC, …Read More >

Resource Type: Brochure
Resource Topic: Antibodies Biochemical Assays Biomarkers Cell-based Assays Cells and Protein Science Chemical Biology and Proteomics Gene Therapies High-throughput screening (HTS) Hit-to-Lead Immunology in vitro biology in vivo Pharmacology Lead Optimization Oncology Screening Libraries Small Molecules Target Identification and Validation Target-Specific Assays Targeted Protein Degradation Tumor Models

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Identification of Tofacitinib, Filgotinib and Ruxolitinib on experimental Sjögren’s syndrome model in mice

Sjögren’s syndrome, which affects hundreds of millions of people worldwide, is a chronic autoimmune disorder characterized by leukocytic infiltration into the exocrine glands, such as the salivary and lacrimal glands. However, the pathological mechanism remains to be elucidated, and novel treatments are urgently needed. Over the past decade, extensive progress has been made in the …Read More >

Resource Type: Poster
Resource Topic: Autoimmune and Inflammatory Diseases in vivo Pharmacology Lead Optimization Rare Diseases Small Molecules Structural Biology

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