Discovery of CVN636: A Highly Potent, Selective, and CNS Penetrant mGluR7 Allosteric Agonist
The metabotropic glutamate receptor mGluR7 is widely expressed throughout the CNS and has been implicated in numerous CNS disorders. WuXi AppTec scientists recently contributed to a study which led to the identification, optimization, and characterization of a highly potent, novel mGluR7 allosteric agonist, designated CVN636. The authors show that CVN636 has high selectivity toward mGluR7, with CNS penetrance and efficacy in an in vivo rodent model of alcohol use disorder.
Related Content
The Son of Sevenless (SOS) protein is a guanine nucleotide exchange factor that acts as a key activator for KRAS...
VIEW RESOURCEThe RAS family of small GTPases are among the most frequently mutated oncogenes in human cancer. Previously viewed as undruggable,...
VIEW RESOURCE