Small Molecules Archives - Page 3 of 11

DEL Insight: Novel Applications with the Bifunctional Linker of DNA-encoded Molecules

Due to the special configuration of the DNA encoded library (DEL), each DEL molecule carries a DNA sequence encoding its...

Combined Inhibition of KRAS G12C and PD1 Boosts Therapeutic Efficacy via Conditioning of Tumor Microenvironment

SITC Poster #466: Mutant KRAS is linked to PD-L1 expression, and oncogenic RAS signaling promotes an immunosuppressive tumor microenvironment by...

Empowering Small Molecule Drug Discovery by Automatic DEL Screening

In this webinar, our expert speakers showcase our automatic DNA-encoded library (DEL) screening device, DELman. DNA-encoded library technology has proven...

Structure-Based Design and Synthesis of Potent and Selective KRAS G12D Inhibitors

The KRAS G12D mutation subtype is present in over 40% of pancreatic ductal adenocarcinomas (PDAC), making this an important drug...

Discovery of CVN636: A Highly Potent, Selective, and CNS Penetrant mGluR7 Allosteric Agonist

The metabotropic glutamate receptor mGluR7 is widely expressed throughout the CNS and has been implicated in numerous CNS disorders. WuXi...

Structural Biology Platform Facilitates Discovery of Glutathione S-Transferase Inhibitors, Offering Novel Pathways for Drug Development

Introduction: WuXi AppTec scientists recently contributed to a study which led to the discovery and optimization of a novel series...

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DEL Insight: Novel Applications with the Bifunctional Linker of DNA-encoded Molecules

Combined Inhibition of KRAS G12C and PD1 Boosts Therapeutic Efficacy via Conditioning of Tumor Microenvironment

Empowering Small Molecule Drug Discovery by Automatic DEL Screening

Structure-Based Design and Synthesis of Potent and Selective KRAS G12D Inhibitors

Discovery of CVN636: A Highly Potent, Selective, and CNS Penetrant mGluR7 Allosteric Agonist

Structural Biology Platform Facilitates Discovery of Glutathione S-Transferase Inhibitors, Offering Novel Pathways for Drug Development

Discovery of Novel GST Inhibitors Identified from a DNA-Encoded Library

Emerging Modalities in Drug Discovery

Discovery and preclinical profile of LX-039, a novel indole-based oral selective estrogen receptor degrader (SERD)

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DEL Insight: Novel Applications with the Bifunctional Linker of DNA-encoded Molecules

Combined Inhibition of KRAS G12C and PD1 Boosts Therapeutic Efficacy via Conditioning of Tumor Microenvironment

Empowering Small Molecule Drug Discovery by Automatic DEL Screening

Structure-Based Design and Synthesis of Potent and Selective KRAS G12D Inhibitors

Discovery of CVN636: A Highly Potent, Selective, and CNS Penetrant mGluR7 Allosteric Agonist

Structural Biology Platform Facilitates Discovery of Glutathione S-Transferase Inhibitors, Offering Novel Pathways for Drug Development

Discovery of Novel GST Inhibitors Identified from a DNA-Encoded Library

Emerging Modalities in Drug Discovery

Discovery and preclinical profile of LX-039, a novel indole-based oral selective estrogen receptor degrader (SERD)﻿

Contact An Expert Today!

Discovery and preclinical profile of LX-039, a novel indole-based oral selective estrogen receptor degrader (SERD)