In Vivo Tumor Models
WuXi Biology has significant experience in oncology drug discovery. We offer a large collection of tumors models for small & large molecule drug discovery.
- Cell line-derived xenograft (CDX) tumor models
- Patient-derived xenograft (PDX) tumor models
- Syngeneic tumor models
- Human immune checkpoint gene KI mouse models
- hPBMC/HSC humanized models
Cell line-derived xenograft (CDX) tumor models
- 280+ validated models covering full range of cancer types
- 77+ cell lines derived from PDX models
- Available data of sensitivities to SOC (standard of care)
- Imaging-based orthotopic/metastatic tumor models
- Brain/bone metastatic models of lung/breast cancer cell lines
28 Luciferase Labelled Orthotopic/Metastatic Tumor Models
- Cover 16 tumor types
- Bioluminescent imaging system in SPF barrier
Patient-derived xenograft (PDX) tumor models
Overview
- 1380+ PDX models covering full range of cancer types
- Fully-characterized models with genetic, molecular and pharmacological profiling
- Drug-resistant PDX models available
- in vitro screening and derivative PDXC/PDXO models
- IO-PDX panel with hPBMC humanization
A Comprehensive PDX Collection of Asia Prevalent Tumors
Syngeneic tumor models
- 70+ syngeneic models (mouse, rat, hamster)
- Responsiveness to immune checkpoint inhibitors (PD-1, PD-L1, CTLA-4, etc.)
- Tumor-infiltrating leukocytes (TILs) map
- WES, RNA-seq and scRNA-seq characterization
hPBMC/HSC Humanized Models
hPBMC Humanized Models
- Established models for immune-checkpoint inhibitor and bi-specific antibody candidates in a human-resembling immune system.
- Annotation for both immune cells (phenotyping, biomarker, functions) and tumor cells (expression, mutation, etc.)
- Different PBMC delivery systems (systemic injection or co-inoculation with tumor)
HSC Humanized Models
- Available humanized models from CIEA combine with WuXi PDX/CDX models.
- Customizable with human cytokine transgenic mice (GM-CSF/hIL-3 or hIL-2) to improve the reconstitution of myeloid lineage.
A List of Established hPBMC Humanized Models
Genetically engineered models
- 48 engineered cell lines based on construct overexpression or gene knock-in
- Pharmacologically validated in vitro and in vivo
- Focusing at drug-resistant mutation introduction and IO-related checkpoint humanization
- Example targets: EGFR, ROS1, ALK, RET, FLT3, BTK, Claudin18.2, PD-L1, etc.
Human immune checkpoint gene KI mouse models
KI (Knock-in) mice offer the possibility to study clinical grade checkpoint antibodies targeting human checkpoints in the context of a fully functional immune system
- Collection of various targets and background mouse strains
- Validated with launched or most advanced clinical grade checkpoint antibodies
- Double checkpoint KI mice customizable for combination (PD1 + OX40, PD1 + TIM3 etc.)
