In vivo Tumor Models

WuXi Biology has significant experience in oncology drug discovery. We offer a large collection of tumors models for small and large molecule drug development, including:
- Cell line-derived xenograft (CDX) tumor models
- Patient-derived xenograft (PDX) tumor models
- Syngeneic tumor models
- Human immune checkpoint gene KI mouse models
- hPBMC/HSC humanized models
Cell line-derived xenograft (CDX) tumor models

- 320+ validated models, covering 30 cancer types
- 77+ cell lines derived from PDX models
- Imaging-based orthotopic/metastatic tumor models
- Brain/bone metastatic models of lung/breast cancer cell lines
- Validated models for efficacy testing of antibody-drug conjugates (ADCs)
- Extensive panel of c-MET related CDX models
41 luciferase labeled orthotopic/metastatic tumor models

- Covering 17 tumor types
- Bioluminescent imaging system
- Specific-pathogen-free (SPF) barrier
Patient-derived xenograft (PDX) tumor models

- 1,400+ PDX models covering full range of cancer types
- Fully-characterized models with genetic, molecular and pharmacological profiling
- Drug-resistant PDX models available
- in vitro screening and derivative PDXC/PDXO models
- Validated models for efficacy testing of antibody-drug conjugates (ADCs)
- Extensive panel of c-MET related PDX models
- PDX panel with hPBMC humanization

Syngeneic tumor models

- 87 syngeneic models (mouse, rat, hamster)
- Comprehensive panel of orthotopic syngeneic tumor models
- Responsiveness to immune checkpoint inhibitors (PD-1, PD-L1, CTLA-4)
- Tumor-infiltrating leukocytes (TILs) map
- WES, RNA-seq and scRNA-seq characterization
hPBMC/HSC humanized models

hPBMC Humanized Models
- Established models for immune-checkpoint inhibitor and bi-specific antibody candidates in a human-resembling immune system.
- Annotation for both immune cells (phenotyping, biomarker, functions) and tumor cells (expression, mutation)
- Different PBMC delivery systems (systemic injection or co-inoculation with tumor)
HSC Humanized Models
- Available humanized models from CIEA combined with WuXi PDX/CDX models.
- Customizable with human cytokine transgenic mice (GM-CSF/hIL-3 or hIL-2) to improve the reconstitution of myeloid lineage.
Established CDX/PDX-hPBMC Models
Genetically engineered models

- 48 engineered cell lines based on construct overexpression or gene knock-in
- Pharmacologically validated in vitro and in vivo
- Focusing at drug-resistant mutation introduction and IO-related checkpoint humanization
- Example targets: EGFR, ROS1, ALK, RET, FLT3, BTK, Claudin18.2, PD-L1
Human immune checkpoint gene KI mouse models

KI (Knock-in) mice offer the possibility to study checkpoint antibodies targeting human checkpoints in the context of a fully functional immune system.
- Collection of various targets and background mouse strains
- Validated with launched or most advanced clinical grade checkpoint antibodies
- Double checkpoint KI mice customizable for combination (PD1 + OX40, PD1 + TIM3)


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