Pain Models & Measurements

During the last 15 years, WuXi Biology has successfully collaborated with the world’s top pharmaceutical companies for CNS drug discovery. Our expertise and experience allow us to offer an extensive portfolio of services supporting drug discovery and development. We match the industry’s needs in the domains of Acute and Chronic Inflammatory Pain, Post surgery pain, Acute nociception, Chronic Neuropathic Pain, Fibromyalgia-like Pain and Osteoarthritis.

Acute nociception

  • Tail Flick
  • Hot Plate

Acute inflammatory pain

  • Formalin
  • Capsaicin induced tactile allodynia
  • Carrageenan

Inflammatory pain

  • CFA
  • NGF
  • Formalin
  • Carrageenan
  • capsaicin, etc.

Post surgical pain

  • Plantar incision (Brennan model)

Itching model

  • Compound 48/80 induced itching model in mice

Chronic neuropathic pain

  • SNL: spinal nerve ligation (Chung model)
  • CCI: chronic constriction injury (Bennett model) (IoN)
  • PNL: partial nerve ligation
  • Chemotherapy pain

Visceral pain

  • Acetic acid writhing

Cystitis/Painful Bladder Syndrome

  • Cyclophosphamide induced interstitial cystitis/bladder pain syndrome (ICBPS)

Diabetic pain

  • STZ induced diabetic pain (rats/mice)
  • db/db mice
  • ob/ob diabetic pain

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