Pain Models & Measurements
During the last 15 years, WuXi Biology has successfully collaborated with the world’s top pharmaceutical companies for CNS drug discovery. Our expertise and experience allow us to offer an extensive portfolio of services supporting drug discovery and development. We match the industry’s needs in the domains of Acute and Chronic Inflammatory Pain, Post surgery pain, Acute nociception, Chronic Neuropathic Pain, Fibromyalgia-like Pain and Osteoarthritis.
Inflammatory Pain
- Formalin
- Capsaicin induced tactile allodynia
- Carrageenan
- Chemical induction
Mouse | Rat
IN VIVO PHARMACOLOGY CATALOG
| NEU-B01-1 | Acute Inflammatory Pain | Formalin induction |
| NEU-B01-2 | Acute Inflammatory Pain | Carrageenan induction |
| NEU-B01-3 | Acute Inflammatory Pain | Capsaicin induction |
| NEU-B02-1 | Chronic Inflammatory Pain | Complete Freund’s adjuvant (CFA) induction |
| NEU-B03-1 | Visceral Pain Model | Acetic acid writhing |
| NEU-B04-1 | Cystitis/Painful Bladder Syndrome | Cyclophosphamide induced interstitial cystitis/bladder pain syndrome (ICBPS) |
Neuropathic Pain
- Surgery models
- Chemical induction
- Tumor induction
- Metabolic induction
- Viral infection
Mouse | Rat
IN VIVO PHARMACOLOGY CATALOG
| NEU-B03-1 | Chronic Neuropathic Pain | spinal nerve ligation (SNL), Chung model |
| NEU-B03-2 | Chronic Neuropathic Pain | Chronic constriction injury (CCI) |
| NEU-B03-3 | Chronic Neuropathic Pain | Spared nerve injury (SNI) |
| NEU-B03-4 | Translational Pain | Chemotherapy induced peripheral neurotoxicity (CIPN) |
| NEU-B03-5 | Translational Pain | Bone cancer pain |
| NEU-B03-6 | Chronic Neuropathic Pain | Diabetic neuropathic pain |
| NEU-B03-7 | Chronic Neuropathic Pain | Varicella-zoster virus (VZV) induced pain |
Post-surgery Pain
- Surgery models
Rat
| NEU-B04-1 | Post Surgery Pain | Bennett model |
| NEU-B04-2 | Post Surgery Pain | Plantar incision (Brennan model) |
Acute Nociception
- Tail Flick
- Hot Plate
Mouse | Rat
BEHAVIORAL TESTS
| NEU-B05-1 | Acute Nociception | Tail flick |
| NEU-B05-2 | Acute Nociception | Hot plate |
Fibromyalgia-like Pain
- Physical induction
Mouse
| NEU-B06-1 | Fibromyalgia-Like Pain | Intermittent cold stress (ICS) |
Osteoarthritis
- Chemical induction
Mouse
| NEU-B07-1 | Osteoarthritis | Monoiodoacetate (MIA) induction |
Migraine
- Electrical stimulation
- Chemical induction
Mouse | Rat
| NEU-B08-1 | Migraine Model | Electrical stimulation of trigeminal ganglion |
| NEU-B08-2 | Migraine Model | Electrical stimulation of closed cranial window (CCW) |
| NEU-B08-1 | Migraine Model | Capsaicin induction |
| NEU-B08-1 | Migraine Model | Nitroglycerin (NTG) induction |
| NEU-B08-1 | Migraine Model | KCl induction, ex vivo |
