Knowledge Library

Bone metastasis platform to evaluate prophylaxis and treatment
Resource Type: Presentation
Resource Topic: Oncology & Immuno-oncology

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Quality Control for DNA-Encoded One-Bead-One-Compound (OBOC) Libraries
Resource Type: Video
Resource Topic: DNA-Encoded Library (DEL)

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Discovery of RNA Targeting Small Molecule Using DNA-Encoded Library Technology
Resource Type: Video
Resource Topic: DNA-Encoded Library (DEL)

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Structure-based optimization of hydroxylactam as potent, cell-active inhibitors of lactate dehydrogenase

Structure-based design was utilized to optimize 6,6-diaryl substituted dihydropyrone and hydroxylactam to obtain inhibitors of lactate dehydrogenase (LDH) with low nanomolar biochemical and single-digit micromolar cellular potencies. Surprisingly the replacement of a phenyl with a pyridyl moiety in the chemical structure revealed a new binding mode for the inhibitors with subtle conformational change of the …Read More >

Resource Type: Publication
Resource Topic: Discovery Chemistry

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Drug Discovery: Screening Approaches for Rapid Assessment of Target Tractability
Resource Type: Webinar
Resource Topic: DNA-Encoded Library (DEL)

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HIJACKING CELLULAR MECHANISMS TO TREAT COMPLEX DISEASES
Resource Type: White Paper
Resource Topic:

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Optimizing Drug Pipelines With Biophysical Methods
Resource Type: White Paper
Resource Topic:

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