Knowledge Library
Bone metastasis platform to evaluate prophylaxis and treatment
Resource Type: Presentation
Resource Topic: Oncology & Immuno-oncology
Quality Control for DNA-Encoded One-Bead-One-Compound (OBOC) Libraries
Resource Type: Video
Resource Topic: DNA-Encoded Library (DEL)
Discovery of RNA Targeting Small Molecule Using DNA-Encoded Library Technology
Resource Type: Video
Resource Topic: DNA-Encoded Library (DEL)
Integrating Practical Machine Learning and Quantum Mechanics Tools to Synthesis in Medicinal Chemistry
Resource Type: Video
Resource Topic: Quantum Mechanics
Structure-based optimization of hydroxylactam as potent, cell-active inhibitors of lactate dehydrogenase
Structure-based design was utilized to optimize 6,6-diaryl substituted dihydropyrone and hydroxylactam to obtain inhibitors of lactate dehydrogenase (LDH) with low nanomolar biochemical and single-digit micromolar cellular potencies. Surprisingly the replacement of a phenyl with a pyridyl moiety in the chemical structure revealed a new binding mode for the inhibitors with subtle conformational change of the …Read More >
Resource Type: Publication
Resource Topic: Discovery Chemistry
Drug Discovery: Screening Approaches for Rapid Assessment of Target Tractability
Resource Type: Webinar
Resource Topic: DNA-Encoded Library (DEL)
HIJACKING CELLULAR MECHANISMS TO TREAT COMPLEX DISEASES
Resource Type: White Paper
Resource Topic:
RARE DISEASES: OPPORTUNITIES AND CHALLENGES FOR TREATMENTS DELIVERED BY ADENO-ASSOCIATED VIRUSES
Resource Type: White Paper
Resource Topic:
Resource Topics
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