Knowledge Library

Application of ML-enriched ASMS for Hit Discovery

GLUT1 serves as the conduit for transporting glucose from the extracellular milieu into the cell, thereby fueling cellular physiological activities via glucose metabolism. Its overexpression has been documented in various tumor cells, establishing GLUT1 as a promising therapeutic target. During an ASMS screening of GLUT1, a counter screen was introduced to effectively mitigate false positives …Read More >

Resource Type: Poster
Resource Topic: Mass Spectrometry-based Assays Screening Libraries

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Application of ASMS for Molecular Glue Discovery

Molecular glues possess the remarkable ability to induce protein-protein interactions. In the pursuit of targeting the CDK12/CCNK/DDB1 complex, an ASMS screening strategy was employed, resulting in the successful identification of two active molecular glues from a subset of 2000 small molecules within the WuXi AppTec compound library. Validation efforts revealed compelling findings: the two small …Read More >

Resource Type: Poster
Resource Topic: Mass Spectrometry-based Assays Screening Libraries

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Precocious Puberty Animal Models

Leveraging Precocious Puberty Animal Models for Preclinical Research Precocious puberty, one of the frequently observed conditions in pediatric endocrinology, significantly impacts the physiological, psychological, and long-term health of children. Moreover, this disorder is associated with increased risks of various diseases [1]. Precocious puberty is an endocrine disorder caused by abnormal secretion of sex hormones. It …Read More >

Resource Type: Article Blog
Resource Topic: in vivo Pharmacology

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Oligonucleotide Services

Sequence design and chemical synthesis In vitro evaluation of stability and efficacy Cell lines 1500+ cell lines and patient-derived fibroblasts Customized stable cell lines available Primary cells Primary hepatocytes of human, mouse, rat, dog and monkey Customized primary cells available Reporter cell lines ASO splicing reporter psiCHECK Methods Free uptake Transfection Additional services include: Stability …Read More >

Resource Type: Brochure
Resource Topic: Oligonucleotides

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mRNA Services Platform

Design and production of mRNA Design and optimization of mRNA sequences Utilizing the design and optimization techniques for mRNA sequences, UTR screening, and codon optimization Plasmid and DNA template productions for in vitro transcription Employment of a classical three-step purification method Implementation of mono-enzyme digestion and purification through chromatography Research scale mRNA production and characterization …Read More >

Resource Type: Brochure
Resource Topic: Oligonucleotides

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Infectious Disease Platform

Capacity Comprehensive virus, bacteria, fungi coverages Supporting drug and vaccine discovery from early research to clinical trials Capability 20+ various viruses Supporting discovery of antivirals and vaccines, including HBV, SARS-CoV, IFV, RSV, HCV, HIV, EV71, herpes, rabies, and other viruses 130+ different bacterial and fungal species Supporting discovery of antibacterial and antifungal therapeutics, including ESKAPE, …Read More >

Resource Type: Brochure
Resource Topic: Infectious Diseases

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Hepatobiliary Disease Platform

Hepatobiliary Disease Platform All-encompassing hepatobiliary disease models: NAFLD, NASH, Fibrosis, Cirrhosis, PBC/PSC, ALD, and more Comprehensive hepatic tissue bank and transcriptomics database Professional quantitative analysis in pathology Histopathology Laboratory CAP-certified pathology laboratory Tissue processor Embedding center Cyostats Microtomes Staining workstation IHC & ISH stainer Laser-scanning confocal microscope HALO-AI quantitative histopathology

Resource Type: Brochure
Resource Topic: in vivo Pharmacology Liver Diseases NASH

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Expanded Role of PDX Models in Anticancer Drug Development

Expanded Role of PDX Models in Anticancer Drug Development Patient-derived xenograft (PDX) models are established by implanting surgically resected patient tumor tissues into immunodeficient mice and have become a pivotal tool in preclinical cancer research due to high clinical-relevance. These models faithfully preserve the original tumor’s molecular, histopathological and pharmacological characteristics, reflecting the heterogeneity and …Read More >

Resource Type: Article Blog
Resource Topic: Oncology Tumor Models

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Comprehensive Evaluation of Gout Models

Gout is a common type of inflammatory arthritis linked to abnormal uric acid metabolism, resulting in the accumulation of urate crystal deposits in joints. To support the development of effective gout therapies, precise animal models are needed to properly evaluate drug candidates. At IMMUNOLOGY2024, WuXi AppTec presented a poster highlighting the development of multiple preclinical …Read More >

Resource Type: Latest Science Poster
Resource Topic: Autoimmune and Inflammatory Diseases in vivo Pharmacology

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