We provide an integrated drug discovery service aimed at addressing our industry challenges. Applying expertise in synthetic and medicinal chemistry, biology, DMPK and program management, we collaborate closely with our global customers, ranging from pharma and biotech to academia, to rapidly advance programs towards key inflection points and milestones by leveraging peer-recognized expertise and an integrated platform from hit identification through to preclinical candidate selection and beyond. 

Integrated chemistry and biology research platform

Our scientists provide drug discovery services and tailored solutions to advance your drug candidate selection in multiple disease areas. Through comprehensive discovery and technology platforms, peer-recognized scientific leadership and expertise in oncology, immunology, infectious disease, neurosciences, fibrosis, cardiovascular and metabolic disease, our teams  work collaboratively to rapidly advance programs from target through to preclinical selection and beyond.

Integrated drug discovery services for new chemical modalities

Our experts provide integrated solutions to global pharma and biotech for challenging targets. We deliver synthetic and medicinal chemistry solutions,  and biology services for creating, identifying, and supporting preclinical candidates, from discovery to development.

Hit Identification

Biological Science

  • Target validation
  • in vitro hit finding
  • DNA-Encoded Libraries
  • High quality protein production
  • Fragment screening and biophysical hit finding
  • X-ray crystallography
  • CADD

Discovery Chemistry

  • Reference compounds
  • Unique scaffolds, building blocks
  • Customized screening decks
  • SAR generation
  • Molecule design
  • Building blocks

Lead Optimization

in vitro and in vivo Biology

  • in vitro SAR support
  • Selectivity and cell panel
  • in vivo target engagement
  • Safety pharmacology
  • Efficacy and Toxicology studies
  • PK/PD analysis

Medicinal Chemistry and Synthetic Chemistry

  • SAR generation
  • Molecule design
  • Building blocks
  • Optimization of hits and leads
  • Data interpretation

Candidate selection

Preclinical Biology

  • Safety profiling services
  • Ligand binding
  • Receptor profiling
  • Additional in vitro and in vivo characterization

Chemistry Services

  • Scale up of candidates for preclinical studies
  • Synthetic optimization of candidates
  • Metabolic and impurity identification synthesis

Clinical l – lll

  • PDX
  • Tumor TILs
  • Biomarkers
  • CAP-certified FACS, pathology, molecular testing

Partnering with us

  • Track record of delivery, leadership and scientific excellence
  • A comprehensive and integrated portfolio of discovery services
  • >7,000 scientists across chemistry, analytical and biology
  • Cost-effective, scalable solutions delivering quality data
  • Global footprint with operations in North America, Asia and Europe
  • Established IP protection policies and procedures. Seamless pathway from our discovery platforms to our development platforms
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