Oncology and Immunology

Comprehensive Platform and Services

Our Oncology & Immunology teams can support all of your research needs, ranging from target discovery to in vitro/in vivo pharmacology, translational research, and clinical biomarker testing to accelerate projects focused on cancer, autoimmune diseases, and rare genetic diseases (RGD).

We have established a disease model library comprised of over 2,000 animal models representing cancer, autoimmune diseases, and rare genetic diseases:

Tumor model libraries of human cancer cell line-derived xenograft (CDX) models, patient-derived xenograft (PDX) models, drug-resistant models and metastasis models.
Immuno-oncology libraries of murine syngeneic tumor models, humanized mice by adoptive and KO/KI approaches
Sub-libraries of autoimmune and inflammation models
Collection of RGD models via genetic engineering

We have a world-class platform for CRISPR/Cas9 mediated in vitro and in vivo screens for target identification and validation, and we have also established a comprehensive Immuno-Oncology translational platform:

Biomarker discovery platform with state of art technology including flow cytometry, NanoString, scRNAseq, RNAscope and multiplex IF;
CAP certified lab for clinical pathology and flow cytometry with over 200 clinical validated biomarkers to support clinical drug development.
Large animal (NHP, canine, swine) based translational research platform with state-of-art facility, comprehensive biomarker research and human correlation capability

One-stop services platform for rare genetic diseases, from animal model creation to pre-clinical testing.

Rich experience in IND-enabling pharmacology studies for both FDA and NMPA filings, as either stand-alone or as integrated drug discovery programs.

Capabilities at a Glance

CRISPR/Cas9 library in vitro + in vivo screen and target validation
282 mouse CDX and 20 rat CDX
33 Orthotopic and 25 Metastasis
1,400 PDX + 77 PDC +20 PDO
89 Drug resistant models
87 Syngeneic models
71 Humanized models
41 Auto-immune models
100 GEAM
AAV packaging
30 Immune assays
100+ Discovery biomarkers
200+ Clinical biomarkers
Spatial transcriptomics analysis
Tumor bone metastasis model
Integrated in vitro/in vivo OVA system for cancer vaccine discovery

Resources at a Glance

700+ scientists with operations at multiple locations
AAALAC credited SPF animal facility with over 30,000 IVC-cages
BSL2 in vitro labs
ABSL2 vivarium
CAP certified clinical pathology and FACS lab

Biology Services

Oncology and Immunology

Comprehensive Platform and Services

Capabilities at a Glance

Resources at a Glance

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