CNS Animal Models
WuXi Biology offers a full range of CNS efficacy and safety pharmacology assessments, from basic models and regulatory tests, to the evaluation of abuse and dependence liability and proconvulsant risk using EEG.
Our experts provide animal models in all areas of psychopharmacology, cognition, epilepsy and neurodegenerative disorders.
in vivo models for Neurodegenerative Diseases
Alzheimer’s disease (AD) models
- Genetically modeling in the mouse: Expression of a human mutant gene or a BAC fragment that is associated with a familial type of AD
- Pharmacologically/neurosurgically modeling in the rat: Ventricular infusion of β-amyloid with an Osmotic mini pump
IN VIVO PHARMACOLOGY CATALOG | AD
NEU-A01-1 | Alzheimer’s Disease Model | AAP/PS1 transgenic mouse |
NEU-A01-2 | Alzheimer’s Disease Model | AAPSWE transgenic mouse |
NEU-A01-3 | Alzheimer’s Disease Model | 5x FAD transgenic mouse |
NEU-A01-4 | Alzheimer’s Disease Model | Streptozotocin (STZ) induction, sporadic |
NEU-A01-5 | Alzheimer’s Disease Model | Neurotoxin (phencyclidine-PCP or cisplatin) induction |
NEU-A01-6 | Alzheimer’s Disease Model | Goto-Kakizaki (GK) type 2 diabetes rat |
Parkinson’s Disease (PD) models
- Genetic model in the mouse: Expression of a mutant gene that is associated with a familial autosomal-dominant mutation, or knockout of a gene that is associated with a familial autosomal-recessive mutation for PD
- Pharmacological / Neurosurgical models
- Systemic administration of MTPT to lesion dopamine neurons in a NHP (under development)
- Behavioral neurology Parkinson’s Disease Dementia (PDD) Model
IN VIVO PHARMACOLOGY CATALOG | PD
NEU- A02-1 | Parkinson’s Disease Model | Unilateral intra-striatal injection of 6-hydroxydopamine (6-OHDA) to lesion nigro-striatal dopamine neurons |
NEU-A02-2 | Parkinson’s Disease Model | moderate to severe DA neuronal loss | 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induction |
NEU-A02-3 | Parkinson’s Disease Model | AAV alpha-synuclein overexpression/preformed fibril (PFF) |
NEU-C02-1 | Parkinson’s Disease Dementia (PDD) Mode | 6-hydroxydopamine (6-OHDA) induction |
Huntington’s Disease model
- Genetic model in the mouse: Expression of a mutant Huntington gene
- Pharmacological/neurosurgical model
IN VIVO PHARMACOLOGY CATALOG | HD
NEU-A03-1 | Huntington’s Disease Model | Trangenic model in the mouse |
NEU-A03-2 | Huntington’s Disease Model | Striatal microinjection of quinolinic acid or 3-NY in the rat |
Multiple Sclerosis Model
Endpoints
- MOG-induced EAE: clinical score, incidence, and inflammation response
- MBP-induced EAE: body weight, clinical score, and incidence rate
- Cuprizone model: grip test, ledged beam test, and myelin staining
IN VIVO PHARMACOLOGY CATALOG | MS
NEU-A04-1 | Multiple Sclerosis Model | Chronic Model | Myelin Oligodendrocyte Glycoprotein (MOG35-55 peptide) induced Experimental Autoimmune Encephalomyelitis (EAE) in C57BL/6 mice |
NEU-A04-2 | Multiple Sclerosis Model | Myelin Basic Protein (MBP68-86 peptide) induced EAE in Lewis rats |
NEU-A04-3 | Multiple Sclerosis Model | Cuprizone intoxication model |
Age-dependent Neurodegeneration
Conditional double knockout PS1/PS2 in the mouse: which shows age-dependent neuronal loss and many other AD-like pathologies such as tau hyperphosphorylation, neurofibrillary tangle-like structure, and dementia
Neurology
Seizure Models
Dementia models
Autism
Stroke Models
- Middle cerebral artery occlusion (MCAO) model in rats
- MCAO reperfusion model in rats
Ischemia model
- Forebrain ischemia model in (rat and gerbil)
Traumatic Brain Injury
BEHAVIORAL NEUROLOGY CATALOG
NEU-C01-1 | Seizure Model | Acute/chronic restraint stress (ARS/CRS) |
NEU-C01-2 | Seizure Model | Learned helplessness (LH) |
NEU-C01-3 | Seizure Model | Chronic corticosterone (CORT) induction |
NEU-C01-4 | Seizure Model | Chronic social defeat stress (CSDS) |
NEU-C02-1 | Parkinson’s Disease Dementia (PDD) Model | 6-hydroxydopamine (6-OHDA) induction |
NEU-C03-1 | Autism spectrum disorder (ASD) Model | Shank +/- |
NEU-C04-1 | Ischemic Stroke | middle cerebral artery occlusion MCAO |
NEU-C04-2 | Forebrain Ischemia Model | four-vessel occlusion (4VO) |
NEU-C05-1 | Traumatic Brain Injury | by external force |
Psychopharmacology | Mental Disorder Models
By combining experience and expertise from both the pharmaceutical industry and academia, we provide valuable services to accelerate drug discovery for the treatment of psychiatrics diseases and mental disorders.
Depression
- Depression Models
- Depression-like behavior
- Behavioral induction
- Chemical induction
NEUROPSYCHIATRIC IN VIVO CATALOG
NEU-C01-1 | Depression Model | Acute/chronic restraint stress (ARS/CRS) |
NEU-C01-2 | Depression Model | Learned helplessness (LH) |
NEU-C01-3 | Depression Model | Chronic corticosterone (CORT) induction |
NEU-C01-4 | Depression Model | Chronic social defeat stress (CSDS) |
NEU-C01-5 | Depression Model | Chronic unpredictable mild stress (CUMS) |
NEU-T03-5 | Behavioral Test | Tail Suspension Test (TST) |
NEU-T03-6 | Behavioral Test | Forced Swim Test (FST) |
NEU-T03-7 | Behavioral Test | Social Interaction Test (SIT) |
NEU-T03-8 | Behavioral Test | Sources Preference Test (SPT) |
Anxiety
- Genetic model in the mouse: Overexpression of the cholecystokinin receptor-2 (CCKR-2) in the forebrain
- Various stress paradigms: early-life stress, chronic stress, or acute stress
- PTSD model in the mouse: combination of genetic manipulation and environmental stress
NEU-T03-1 | Behavioral Test Anxiety | Elevated Plus Maze Test (EPM) |
NEU-T03-2 | Behavioral Test Anxiety | Vogel Test |
NEU-T03-3 | Behavioral Test Anxiety | Open Field Test (OFT) |
NEU-T03-4 | Behavioral Test Anxiety | Novelty Suppressed Feeding (NSF) |
Schizophrenia
Bipolar disorder
- Experimental Psychiatry
- Behavioral induction
- Chemical induction
Mouse | Rat
NEU-C02-1 | Schizophrenia Model | Drug-induced hyperlocomotion, positive symptoms |
NEU-C02-2 | Schizophrenia Model | Acute restraint stress (ARS), negative symptoms |
NEU-C02-3 | Schizophrenia Model | Chronic corticosterone (CORT) induction, negative symptoms |
NEU-T03-9 | Behavioral Test | Anti Schizophrenic | Conditioned Avoidance Response (CAR) |
NEU-T03-10 | Behavioral Test | Schizophrenia, cognitive | Pre-pulse Inhibition (PPI) |
NEU-T03-11 | Behavioral Test | Schizophrenia, cognitive | Attentional Set-Shifting Test (ED/ID test) |
NEU-T03-12 | Behavioral Test | Schizophrenia, negative | 3-Chamber Social Interaction Test |
Addiction
- Behavioral sensitization
- Drug-seeking behavior
- Behavioral induction
- Chemical & behavioral induction
Mouse | Rat
DRUG ADDICTIVE BEHAVIOR | IN VIVO CATALOG
NEU-E01-1 | Addiction Model | Conditioned place preference (CPP) |
NEU-E01-2 | Addiction Model | Self-administration (SA) |
NEU-E01-3 | Addiction Model | Behavioral sensitization (BS) |
Neurosensory Diseases
Hearing Loss and Vestibular Dysfunction
Hearing Loss
Ocular Degeneration
- Surgery & chemical
- Physical induction
- Transgenic model
Mouse | Rat | Guinea pig
NEUROSENSORY DISEASES MODELS | IN VIVO CATALOG
NEU-F01-1 | Hearing Loss & Vestibular Dysfunction Model | Aminoglycoside antibiotics induction |
NEU-F01-2 | Hearing Loss & Vestibular Dysfunction Model | Self-administration (SA) |
NEU-F02-1 | Hearing Loss Model | 3,3′-Iminodipropionitrile (IDPN) induction |
NEU-F02-4 | Hearing Loss Model | Noise induction |
NEU-F03-1 | Rod and Cone Degeneration Model | Aged rodless/coneless transgenic mouse |
Motor Neuron Diseases
Amyotrophic Lateral Sclerosis
NEU-G01-1 | Amyotrophic lateral sclerosis (ALS) Model | SOD1G93A transgenic rat |
Insomnia
Amyotrophic Lateral Sclerosis
- Chemical induction
- Surgery
Mouse | Rat
NEU-H01-1 | Insomnia Model | Caffeine induction |
NEU-H01-2 | Insomnia Model | Post-surgery |
Electrophysiology
ELECTROPHYSIOLOGICAL TESTS
Electrogram
Evoke Potential
Nerve Conduction Velocity
Auditory Brainstem Response
Vestibule-Ocular Reflex
Telemetry
Muscle Strength Test
Ex Vivo Test
NEU-U01-1 | Elelctrogram | Electroencephalogram (EEG) |
NEU-U01-2 | Elelctrogram | Electrocardiogram (ECG) |
NEU-U01-3 | Elelctrogram | Electromyogram (EMG) |
NEU-U01-4 | Elelctrogram | Sleeping Architecture Analysis |
NEU-U02-1 | Evoke Potential | Visual Evoked Potential (VEP) |
NEU-U02-1 | Evoke Potential | Evoked Response of Wide Dynamic Range (WDR) Neuron |
NEU-U03-1 | Nerve Conduction Velocity | Nerve Conduction Velocity Test |
NEU-U04-1 | Auditory Brainstem Response | Auditory Brainstem Response (ABR) |
NEU-U05-1 | Vestibule-Ocular Reflex | Vestibule-Ocular Reflex (VOR) |
NEU-U06-1 | Telemetry | Telemetry of Blood Pressure |
NEU-U06-2 | Telemetry | Telemetry of Body Temperature |
NEU-U06-3 | Telemetry | Telemetry of Spontaneous Activity |
NEU-U07-1 | Muscle Strength | Muscle Strength Test |
NEU-U08-1 | Ex Vivo Test | Langendorff Test of Perfused Heart |
NEU-U08-2 | Ex Vivo Test | Muscle Contraction Test |
Behavioral Studies
Learning and memory
- Morris water maze
- Spatial learning and memory, working memory, reference memory, reversal learning, hippocampus-dependent memory
- Barnes maze
- Spatial learning and contextual conditioning (hippocampus-dependent)
- Cued conditioning (hippocampus-independent)
- Long-term memory, short-term memory, amygdala-dependent memory, fear response
Motor function
- Rotarod test
- Open-field test
- Walking-beam test
- Treadmill test (under development)
Anxiety-like behavior
- Elevated-plus maze
- Fear-conditioning test
- Open-field behavior
- Startle response
- Social interaction
Depression-like behavior
- Novelty-induced hypophagia
- Tail suspension test
- Forced swim test
- Open-field behavior
- Social interaction
- Learned helplessness
Schizophrenia/bipolar-like behavior
- Working memory
- Locomotion/motor activity
- Social interaction
- Aggressive/mania-like behavior
- Forced swim test
- Nesting behavior
- Pre-pulse inhibition (PPI) under development
Home cage behavior and environmental enrichment
Pain-related behavior
- Hot-plate
- Tail flick (infrared heat/pressure)
BEHAVIORAL TESTS
NEU-T01-1 | Cognitive Behavior | Novel Object Recognition (NOR) |
NEU-T01-2 | Cognitive Behavior | Fear Conditioning |
NEU-T01-3 | Cognitive Behavior | Morris Water Maze |
NEU-T01-4 | Cognitive Behavior | Object Location Memory Task |
NEU-T01-5 | Cognitive Behavior | Passive Avoidance Task |
NEU-T01-6 | Cognitive Behavior | T Maze |
NEU-T01-7 | Cognitive Behavior | Y Maze |
NEU-T01-8 | Cognitive Behavior | Training box |
NEU-T02-1 | Sensorimotor Behavior | Activity Chamber |
NEU-T02-2 | Sensorimotor Behavior | Basket Test |
NEU-T02-3 | Sensorimotor Behavior | Cylinder Test |
NEU-T02-4 | Sensorimotor Behavior | Grip Strength |
NEU-T02-5 | Sensorimotor Behavior | Hot Plate |
NEU-T02-6 | Sensorimotor Behavior | Ledged Beam Test |
NEU-T02-7 | Sensorimotor Behavior | Neurological Testing |
NEU-T02-8 | Sensorimotor Behavior | Rotor-Rod |
NEU-T02-9 | Sensorimotor Behavior | Wire Hang Test |
NEU-T02-10 | Sensorimotor Behavior | Balance Beam Test |
NEU-T02-11 | Sensorimotor Behavior | Olfactory Test |
NEU-T02-12 | Sensorimotor Behavior | Irwin Test |
NEU-T02-13 | Sensorimotor Behavior | Visual Placing Response |
NEU-T02-14 | Sensorimotor Behavior | Visual Water Maze |
NEU-T02-15 | Sensorimotor Behavior | Visual Cliff Test |
NEU-T03-1 | Experimental Psychiatry | Anxiety | Elevated Plus Maze Test (EPM) |
NEU-T03-2 | Experimental Psychiatry | Anxiety | Vogel Test |
NEU-T03-3 | Experimental Psychiatry | Anxiety | Open Field Test (OFT) |
NEU-T03-4 | Experimental Psychiatry | Anxiety| Novelty Suppressed Feeding (NSF) |
NEU-T03-5 | Experimental Psychiatry | Depression | Tail Suspension Test (TST) |
NEU-T03-6 | Experimental Psychiatry | Depression | Forced Swim Test (FST) |
NEU-T03-7 | Experimental Psychiatry | Depression | Social Interaction Test (SIT) |
NEU-T03-8 | Experimental Psychiatry | Depression | Sources Preference Test (SPT) |
NEU-T03-9 | Experimental Psychiatry | Anti Schizophrenic | Conditioned Avoidance Response (CAR) |
NEU-T03-10 | Experimental Psychiatry | Schizophrenia, cognitive | Pre-pulse Inhibition (PPI) |
NEU-T03-11 | Experimental Psychiatry | Schizophrenia, cognitive | Attentional Set-Shifting Test (ED/ID test) |
NEU-T03-12 | Experimental Psychiatry | Schizophrenia, negative | 3-Chamber Social Interaction Test |
NEU-T03-13 | Experimental Psychiatry | Obsessive-Compulsive Disorder | Marble Burying Test |
NEU-T03-14 | Experimental Psychiatry | Social Behavior | 3-Chamber Sociability and Social Novelty Test |
NEU-T03-15 | Experimental Psychiatry | Social Behavior | Tube Dominance Test |