Knowledge Library

Application of Affinity Selection Mass Spectrometry: Membrane Proteins

Introduction Membrane proteins are essential for various cellular processes, including energy conversion, signal transduction, and disease progression. Efficient and accurate identification and screening of these proteins are vital for the development of small-molecule therapeutics targeting membrane proteins. In recent years, Affinity Selection Mass Spectrometry (ASMS) has become a powerful tool for studying membrane protein-small molecule …Read More >

Resource Type: Article, Blog
Resource Topic: Mass Spectrometry-based Assays

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Application of Affinity Selection Mass Spectrometry: Molecular Glues Drug Discovery

Introduction: New modalities, such as molecular glues, require robust screening strategies to identify and develop the most promising candidates efficiently. In this article, we spotlight Affinity Selection Mass Spectrometry (ASMS), a versatile and cost-effective high-throughput screening technique used in drug discovery. ASMS: A Powerful High-throughput Screening Technology Since the mid-1990s, ASMS has emerged as a …Read More >

Resource Type: Article, Blog
Resource Topic: Mass Spectrometry-based Assays

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OncoWuXi Express: Anti-Tumor mRNA Drugs

OncoWuXi Express will continue to keep you informed about updates to our online tumor model database (OncoWuXi Database), as well as our recent progress in cancer and autoimmune research. In this issue, we would like to share our experience with mRNA drug development and their anti-tumor efficacy. OncoWuXi Introduction to Nucleic Acid Drugs RNA-based therapies …Read More >

Resource Type: Article, Blog
Resource Topic: Oligonucleotides, Oncology

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OncoWuXi Express: PDX Panel Service

OncoWuXi Express will continue to keep you informed about updates to our online tumor model database (OncoWuXi Database), as well as our recent progress in cancer and autoimmune research. In this issue, we would like to share our newly launched PDX panel service with you. https://onco.wuxiapptec.com Introduction: Patient-derived xenograft (PDX) models are generated by implanting …Read More >

Resource Type: Article, Blog
Resource Topic: Oncology, Tumor Models

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OncoWuXi Express: Efficacy of JAK Inhibitors in a Type II Collagen-induced Arthritis Model

Introduction: OncoWuXi Express will continue to keep you informed about updates to our online tumor model database (OncoWuXi Database), as well as our recent progress in cancer and autoimmune research. In this issue, we present an evaluation of the efficacy of different JAK subtype inhibitors in a Type II collagen-induced arthritis model, along with corresponding …Read More >

Resource Type: Article, Blog
Resource Topic: Autoimmune and Inflammatory Diseases, Immunology, in vivo Pharmacology

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In Vivo Pharmacology for Ophthalmic Drug Development

Introduction The number of people with vision impairment has increased due to the continuously expanding and aging population, as well as lifestyle changes. According to the Lancet Global Health, by 2050, myopia is expected to affect 5 billion people. Additionally, the number of individuals with distance vision impairment is projected to reach 895 million, including …Read More >

Resource Type: Article, Blog
Resource Topic: in vivo Pharmacology

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Advances and Biological Evaluation of Diabetes Drugs

Introduction: Diabetes is a chronic, metabolic disease resulting from defects in insulin secretion and varying degrees of insulin resistance. Early symptoms include increased thirst and urination, increased hunger, and blurred vision. Progressively, complications such as cardiovascular disease, peripheral neuropathy, nerve damage, myocardial disease, and kidney disease may occur. The prevalence of diabetes at younger ages …Read More >

Resource Type: Article, Blog
Resource Topic: Biochemical Assays, in vitro biology, Metabolic Diseases

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OncoWuXi Express: Efficacy of DLL3 CAR-T in SHP-77 Tumor Models

OncoWuXi Express: Evaluation of DLL3 CAR-T in SHP-77-Luc Tumor Models  Introduction: OncoWuXi Express will continue to keep you informed about updates to our online tumor model database (OncoWuXi Database), as well as our recent progress in cancer and autoimmune research. In this issue, we showcase our DLL3 CAR-T cell preparation and evaluation of their anti-tumor …Read More >

Resource Type: Article, Blog
Resource Topic: CAR-T Cell, Oncology, Tumor Models

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Accelerating GPCR Drug Discovery and Development

GPCRs: Function, Structure, and Classifications G protein-coupled receptors (GPCRs) are a prevalent class of transmembrane proteins in animal cells, representing one of the largest families of membrane proteins in mammals. These receptors are widely distributed across numerous organs and regulate physiological functions by stimulating intracellular signaling pathways, thereby influencing cellular behavior. GPCRs have a central …Read More >

Resource Type: Article, Blog
Resource Topic: Biochemical Assays, Cell-based Assays, Hit-to-Lead, in vitro biology

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