Abstract: Emerging as a major global health concern, metabolic dysfunction-associated steatohepatitis (MASH) is closely linked to obesity, type 2 diabetes, and other metabolic disorders. Advances in metabolic research have positioned glucagon-like peptide-1 receptor agonists (GLP-1 RAs) as a promising therapeutic option for MASH, extending their use beyond diabetes and obesity management. This article examines the …Read More >

Introduction In recognition of International Women’s Day, we spotlight women’s health—a continuously evolving global healthcare issue. The year 2025 marks the 30th anniversary of the United Nations Fourth World Conference on Women, where the landmark Beijing Declaration was adopted. This pivotal document systematically outlined an action framework for advocating women’s rights, with a particular emphasis …Read More >

Introduction: Women spend about one-third of their lives in menopause or post-menopause, a period that marks the gradual decline of their reproductive capabilities [1, 2]. Menopause typically begins between the ages of 45 and 55 and is marked by 12 consecutive months without menstruation. Menopausal syndrome refers to a series of physiological and psychological symptoms …Read More >

Introduction: Fibrosis is a pathological process characterized by the excessive deposition of extracellular matrix (ECM) within an organ, leading to significant damage to its structure and function, which can potentially impact multiple organs such as the lungs, liver, heart, kidneys, and skin (Fig.1). Notable examples of fibrotic diseases include idiopathic pulmonary fibrosis (IPF), liver cirrhosis, …Read More >

Introduction： OncoWuXi Express will continue to keep you informed about updates to our online tumor model database (OncoWuXi Database), as well as our recent progress in cancer and autoimmune research. In this issue, we would like to share with you our preclinical pharmacological evaluation platform for T cell engagers. https://onco.wuxiapptec.com Introduction T-cell engagers (TCEs) are …Read More >

Inflammatory bowel disease (IBD) is a chronic intestinal inflammatory condition that is mediated by genetic, immune, and environmental factors. Due to its long-term, relapsing course, IBD can result in repeated cycles of mucosal damage and repair, potentially increasing the risk of colorectal cancer over time. While current treatments focus on reducing inflammation, they are less …Read More >

Introduction: Molecular glues (MGs) are a class of small molecules that alter the surface properties of proteins to strengthen or induce protein-protein interactions (PPI), leading to specific biological effects like protein degradation, pathway inhibition, or activation. Their unique properties endow them with high selectivity and bioavailability, allowing for controlled drug release. Molecular glues show great …Read More >

OncoWuXi Express will continue to keep you informed about updates to our online tumor model database (OncoWuXi Database), as well as our recent progress in cancer and autoimmune research. In this issue, we showcase various induced acute and chronic pancreatitis models and the evaluation of anti-pancreatic drug efficacy. https://onco.wuxiapptec.com Introduction: Pancreatitis is one of the …Read More >

Introduction Membrane proteins are essential for various cellular processes, including energy conversion, signal transduction, and disease progression. Efficient and accurate identification and screening of these proteins are vital for the development of small-molecule therapeutics targeting membrane proteins. In recent years, Affinity Selection Mass Spectrometry (ASMS) has become a powerful tool for studying membrane protein-small molecule …Read More >