Autoimmune and Inflammatory Animal Models

Our team of experts has developed in vivo models for autoimmune and inflammatory diseases. We offer inflammation animal models associated with neurological diseases, respiratory diseases, arthritis, skin diseases, gastrointestinal diseases and topical inflammation.


Autoimmune Diseases

Rheumatoid Arthritis (RA) Models

  • Collagen-induced arthritis (CIA) in DBA/1 mice
  • Collagen-induced arthritis (CIA) in Lewis rats
  • Adjuvant-induced arthritis (AIA) in Lewis rats
  • hTNFa transgenic mice

Multiple Sclerosis (MS) Models

  • MOG-induced (experimental autoimmune encephalomyelitis, EAE) in C57BL/6 mice
  • MBP-induced EAE in Lewis rats
  • PLP-induced relapsing-remitting EAE in SJL mice

Experimental Autoimmune Encephalomyolitis (EAE)

  • Myelin Oligodendrocyte Glycoprotein (MOG35-55) induced EAE in C57BL/6 mice – chronic model; 
  • Proteolipid Protein (PLP139-151) induced EAE in SJL/J mice – relapse-remitting model;     
  • Cuprizone induced EAE in SJL/J mice – demyelination model
  • Myelin Oligodendrocyte Glycoprotein (MOG1-125) induced EAE in C57BL/6 mice – chronic B cell dependent model (under development)

Dermal Inflammation

Delayed Type Hypersensitivity (DTH) Models  

  • Oxazolone-induced DTH in mice
  • DNFB-induced DTH in mice

Psoriasis Model

  • Imiquimod-induced psoriasis-like skin inflammation in mice
  • IL-23-induced eczema in mice

Atopic Dermatitis

  • DNCB induced AD model
  • PMA induced AD model

Septic Shock 

  • LPS-induced airway inflammation in Wistar rats
  • LPS-induced cytokine model in mice and rats

Acute Inflammation Models

  • ConA-induced cytokine model in mice and rats
  • R848 (Resiquimod) induced cytokine model in mice and rats
  • CLP induced sepsis model in mouse
  • Anti CD3 antibody induced inflammation in mouse
  • TNF alpha shock model
  • KLH induced T cell dependent Antibody Response in mice
  • Zymosan induced peritonitis model
  • Carrageenan induced paw edema model

Respiratory inflammation

Acute Lung Inflammation

  • Intra-tracheal LPS induced acute lung inflammation in Sprague Dawley (SD) rats;
  • Intra-venous LPS induced acute lung inflammation in Balb/c mice;
  • Intra-nasal LPS induced acute lung inflammation in Balb/c mice.

Allergic Rhinitis

  • Ovalbumin induced rhinitis in Balb/c mice

Lung Fibrosis

  • Bleomycin induced lung fibrosis in ICR mice

Asthma

  • Ovalbumin induced asthma in Balb/c mice
  • Ovalbumin induced asthma in Brown Norway rats

Gout Models

  • Oteracil potassium-induced hyperuricemia
  • MSU-induced air pouch inflammation

Digestive System

IBS/IBD animal models

Inflammatory bowel disease (IBD) is an autoimmune disease caused by a dysregulated immune response to host intestinal microbiota. There are two major types of IBD: ulcerative colitis (UC) and Crohn’s disease (CD). 

Irritable bowel syndrome (IBS) is a condition that produces similar symptoms to those of IBD but without GI tract inflammation. More than 5 million people live with a form of IBD and 0.7 billion people suffer with IBS. Currently there is no well-developed cure for IBD or IBS. WuXi Biology has fully developed animal models for new compound development for both IBD and IBS.

IBD/IBS Models:

  • DSS-Induced IBD: Acute
  • DSS-Induced IBD: Chronic
  • TNBS-Induced IBD
  • T Cell Transfer Model of Colitis
  • Telemetry Irritable bowel syndrome (IBS) model

Deliverables:

  • Time course of body weight change
  • Disease scores, organ length and weight
  • Blood biochemical analysis, including white cells and interleukins etc.
  • Histopathology scoring of collected tissue
  • Telemetry EMG signaling and analysis for IBS

A Custom Protocol is designed for a study to meet Sponsor’s requirements.

Figure 1. Cyclosporin A effects in IBD model
Figure 2. Tegaserod effects on EMG in IBS model
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