Autoimmune and Inflammatory Animal Models
Our team of experts has developed in vivo models for autoimmune and inflammatory diseases. We offer inflammation animal models associated with neurological diseases, respiratory diseases, arthritis, skin diseases, gastrointestinal diseases and topical inflammation.
Autoimmune Diseases
Rheumatoid Arthritis (RA) Models
- Collagen-induced arthritis (CIA) in DBA/1 mice
- Collagen-induced arthritis (CIA) in Lewis rats
- Adjuvant-induced arthritis (AIA) in Lewis rats
- hTNFa transgenic mice
Multiple Sclerosis (MS) Models
- MOG-induced (experimental autoimmune encephalomyelitis, EAE) in C57BL/6 mice
- MBP-induced EAE in Lewis rats
- PLP-induced relapsing-remitting EAE in SJL mice
Experimental Autoimmune Encephalomyolitis (EAE)
- Myelin Oligodendrocyte Glycoprotein (MOG35-55) induced EAE in C57BL/6 mice – chronic model;
- Proteolipid Protein (PLP139-151) induced EAE in SJL/J mice – relapse-remitting model;
- Cuprizone induced EAE in SJL/J mice – demyelination model
- Myelin Oligodendrocyte Glycoprotein (MOG1-125) induced EAE in C57BL/6 mice – chronic B cell dependent model (under development)
Dermal Inflammation
Delayed Type Hypersensitivity (DTH) Models
- Oxazolone-induced DTH in mice
- DNFB-induced DTH in mice
Psoriasis Model
- Imiquimod-induced psoriasis-like skin inflammation in mice
- IL-23-induced eczema in mice
Atopic Dermatitis
- DNCB induced AD model
- PMA induced AD model
Septic Shock
- LPS-induced airway inflammation in Wistar rats
- LPS-induced cytokine model in mice and rats
Inflammation Models
- ConA-induced cytokine model in mice and rats
- Non-alcoholic steatohepatitis (NASH) liver models in mice and rats
- R848 (Resiquimod) induced cytokine model in mice and rats
- CLP induced sepsis model in mice
- Anti CD3 antibody induced inflammation in mice
- TNF alpha shock model
- KLH induced T cell dependent Antibody Response in mice
- Zymosan induced peritonitis model
- Carrageenan induced paw edema model
Respiratory inflammation
Acute Lung Inflammation
- Intra-tracheal LPS induced acute lung inflammation in Sprague Dawley (SD) rats;
- Intra-venous LPS induced acute lung inflammation in Balb/c mice;
- Intra-nasal LPS induced acute lung inflammation in Balb/c mice.
Allergic Rhinitis
- Ovalbumin induced rhinitis in Balb/c mice
Lung Fibrosis
- Bleomycin induced lung fibrosis in ICR mice
Asthma
- Ovalbumin induced asthma in Balb/c mice
- Ovalbumin induced asthma in Brown Norway rats
Gout Models
- Oteracil potassium-induced hyperuricemia
- MSU-induced air pouch inflammation
Digestive System
IBS/IBD animal models
Inflammatory bowel disease (IBD) is an autoimmune disease caused by a dysregulated immune response to host intestinal microbiota. There are two major types of IBD: ulcerative colitis (UC) and Crohn’s disease (CD).
Irritable bowel syndrome (IBS) is a condition that produces similar symptoms to those of IBD but without GI tract inflammation. More than 5 million people live with a form of IBD and 0.7 billion people suffer with IBS. Currently there is no well-developed cure for IBD or IBS. WuXi Biology has fully developed animal models for new compound development for both IBD and IBS.
IBD/IBS Models:
- DSS-Induced IBD: Acute
- DSS-Induced IBD: Chronic
- TNBS-Induced IBD
- T Cell Transfer Model of Colitis
- Telemetry Irritable bowel syndrome (IBS) model
Deliverables:
- Time course of body weight change
- Disease scores, organ length and weight
- Blood biochemical analysis, including white cells and interleukins etc.
- Histopathology scoring of collected tissue
- Telemetry EMG signaling and analysis for IBS
A Custom Protocol is designed for a study to meet Sponsor’s requirements.
