Analytical Chemistry in Drug Discovery
Providing Integrated Analytical Services with High Quality in a Rapid & Cost Saving Manner
The Core Analytical Services are led by a group of dedicated and knowledgeable leaders with extensive analytical experience. Our focus on new technology and continuous innovation enables us to offer our clients specialized services in chiral separation, high-throughput purification, physiochemical property determination, impurity isolation and identification. We provide accurate high quality data with reasonable rates. The Chemistry Analysis team is equipped with best-in-class automated instruments to provide extensive analytical and purification services in a rapid manner.
A Leading Platform for Analytical, Purification and Structure Elucidation Service
Pharmaceutical Analysis and Quality Control
Physicochemical Characterization & Compound Validation
- Milligram scale chiral and achiral separations.
- Large scale (up to hundreds of kg) chiral and achiral separations.
- Regulatory-driven analytical services for drug development including monitoring and quality control for APIs, intermediates, raw materials and finished products
- Isolation and structure elucidation of impurities of APIs and drug products.
- Physicochemical property determination (pKa, LogP/LogD, Solubility and Concentration)
- Natural products extraction, isolation and structure elucidation
- High throughput screening of small molecules with affinity selection mass spectrometry (ASMS)
Best-in-class Automated Instruments
- 14 sets of analytical SFC instruments and wide collection of chiral columns
- 11 sets of semi-preparative SFC instruments (flow rate 70-100 ml/min) with 3cm columns.
- 10 sets of prep-SFC instruments (flow rate 200-350 mL/min) with 5 cm columns.
- 38 sets of prep-HPLC instruments with 5 cm, 8 cm and 10 cm columns.
- 92 sets of semi prep-HPLC instruments with 2.5 cm and 3 cm ID columns
- 30 sets of NMR instruments, some coupled with low temperature probe.
- 111 sets of analytical LCMS, some coupled with triple quad, TOF, and Orbitrap mass spectrometers.
- 121 sets of HPLC.
Why choose WuXi Core Analytical Services?
Chiral separation (mg to multi kg)
15,000 samples each year
700,000 compounds annually
Structure confirmation/elucidation (HRMS, 1D/2D, NMR)
1,800,000 compounds annually
Physicochemical property determinatoin( pKa, LogP/LogD, and thermodynamic and kinetic solubility, concentration)
30,000 compounds annually
Natural products extraction, purification, structure identification and quality analysis
2,000 compounds annually
Isolation and structure elucidation for impurities of regulatory starting materials, intermediates, APIs and drug products
500 impurities annually