DELs enable the development of BRET probes for target engagement studies in cells

WuXi AppTec scientists recently contributed to a research article in Cell Chemical Biology demonstrating the successful conversion of ligands identified from DNA-encoded library (DEL) screening into highly functional, cell-active, bioluminescence resonance energy transfer (BRET) probes. The authors show that analyzing preliminary DEL hits based on target occupancy data generated in live, intact cells is an effective approach for the validation of small-molecule inhibitors.

Read the full article by clicking here.

Check out our comprehensive platform of DEL services

View Now
← Return to Resources

Related Content

Despite the success of delivery technologies such as lipid nanoparticles and trivalent GalNAc conjugation, targeted delivery of oligonucleotides to extra...


WuXi AppTec scientists contributed to a research article in the journal Translational Medicine Communications which characterized the antitumor immune responses...

← View all Cell-based Assays Resources
× peptide, amino acid

Contact An Expert Today!