Knowledge Library

DNA-Compatible Cyclizations

DNA-encoded chemical library (DECL) technology is a commonly employed screening platform in both the pharmaceutical industry and academia. To expand the chemical space of DECLs, new and robust DNA-compatible reactions are sought after.  WuXi AppTec scientists recently published a research article in the journal Organic Letters describing two new methodologies for DNA-compatible cyclizations to form …Read More >

Resource Type: Latest Science Publication
Resource Topic: Discovery Chemistry DNA-Encoded Library (DEL) Small Molecules

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DEL Insight: Novel Applications with the Bifunctional Linker of DNA-encoded Molecules

Due to the special configuration of the DNA encoded library (DEL), each DEL molecule carries a DNA sequence encoding its identity through a bifunctional linker. The linkers that are considered “redundant” and “troublesome” in traditional drug discovery actually offer innate advantages in many application scenarios. In this article, we review how to utilize DNA-encoded libraries …Read More >

Resource Type: Article Blog
Resource Topic: DNA-Encoded Library (DEL) Hit Finding Small Molecules

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Emerging Drug Discovery Strategies for Targeted Protein Degradation

In the last decade, targeted protein degradation (TPD) technology has become one of the most promising methods to remove specific disease-related proteins using cellular self-destruction mechanisms.  In our latest White Paper, “Emerging Drug Discovery Strategies for Targeted Protein Degradation” we explore how DNA-encoded library (DEL) technology can be used for direct discovery of proteolysis-targeting chimeras …Read More >

Resource Type: Latest Science White Paper
Resource Topic: Discovery Chemistry DNA-Encoded Library (DEL) Targeted Protein Degradation

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Pioneering Advanced Modalities in Early Drug Discovery

New modalities such as peptides, oligonucleotides, and cell and gene therapies have revolutionized healthcare industry innovation. To meet these evolving needs, WuXi Biology has proactively developed a broad range of capabilities, offering integrated solutions to global pharmaceutical and biotech companies for challenging targets. We have established major capabilities for new modalities in the early discovery …Read More >

Resource Type: Article
Resource Topic: Antibody Drug Conjugate CAR-T Cell Cell Therapies DNA-Encoded Library (DEL) Fragment-Based Drug Discovery Gene Therapies Oligonucleotides Oncolytic Viruses Targeted Protein Degradation

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Negative Allosteric Modulation of the µ-Opioid Receptor

DNA-encoded libraries from WuXi AppTec were used in a “steered” screening against either inactive or active μ-opioid receptors in parallel, to find novel negative allosteric modulators of this receptor. The molecule discovered via DEL screening not only shows direct and effective in vitro and in vivo potency, but also helps elucidate the mechanism of negative allosteric modulation of GPCRs. This discovery …Read More >

Resource Type: Latest Science Publication
Resource Topic: Central Nervous System & Pain DNA-Encoded Library (DEL) Hit Finding Small Molecules

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Empowering Small Molecule Drug Discovery by Automatic DEL Screening

In this webinar, our expert speakers showcase our automatic DNA-encoded library (DEL) screening device, DELman. DNA-encoded library technology has proven to be a powerful tool for drug discovery. There are now several DEL-derived candidates in clinical stage. DEL enables researchers to explore vast chemical space with millions to billions of compounds. With DELman and other …Read More >

Resource Type: Webinar
Resource Topic: DNA-Encoded Library (DEL) Hit Finding Small Molecules

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Recent Advances in Peptide Drug Discovery

Peptides, and in particular macrocyclic peptides, are well known for their ability to disrupt protein-protein interactions (PPIs).  In this webinar, learn how DNA encoded library (DEL) screening can be used to discover peptide macrocycles that disrupt PPIs.  Our speakers present a case study using the oncoprotein murine double minute 2 (MDM2). We will also highlight the …Read More >

Resource Type: Webinar
Resource Topic: Biophysical Assays DNA-Encoded Library (DEL) Hit Finding

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Screening Methods to Identify RNA-Targeting Small Molecules

RNA molecules are promising drug targets due to their genomic prevalence, disease involvement, and druggable complex structures. Successful examples include RNA-targeting small molecule drugs for spinal muscular atrophy (SMA), with on-going efforts in other RNA-related diseases. Here, Dr. Zhifeng Yu presents our toolbox for discovering RNA-targeting small molecules, with a focus on unique DNA-encoded libraries …Read More >

Resource Type: Webinar
Resource Topic: Biophysical Assays DNA-Encoded Library (DEL) Hit Finding Mass Spectrometry-based Assays

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Discovery of Novel GST Inhibitors Identified from a DNA-Encoded Library

WuXi AppTec scientists recently contributed to a study which led to the discovery and optimization of a novel series of GST inhibitors. The authors used affinity mediated DEL selection against a privileged scaffold to identify a compound with potent inhibition against SjGST and GSTM2. SAR studies, coupled with X-ray crystallography and structural analysis, revealed that …Read More >

Resource Type: Latest Science Publication
Resource Topic: Biochemical Assays DNA-Encoded Library (DEL) Hit Finding Hit-to-Lead Lead Optimization Small Molecules Structural Biology

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Resource Topics
× peptide, amino acid

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