DNA-Encoded Library Sharing Platform
DNA-encoded library (DEL) is a technology that enables fast screening of billions of small molecule compounds in early phase of drug discovery. The aim of DEL technology is to discover novel chemical structures for validation and optimization. DELopen provides free access to DNA-encoded libraries (DEL) for academic users and encourages an open, community-based approach to data sharing
DELopen | DNA-Encoded Libraries (DEL) for Academic Users
DELopen users are able to conduct affinity selection experiments in their own labs, and WuXi Biology is responsible for post-selection processing, sequencing and data analysis. If promising hits are identified and validated, users can choose to disclose their target in exchange for the chemical structures.
- Free access
- Well-balanced chemical space
- Data sharing
- Compatible with computational tools
DELopen platform is dedicated to the development and application of DEL technology in drug discovery, initiated by WuXi AppTec in conjunction with leading academic researchers.
“With the support provided in this partnership we aim to bridge academia and industry and jointly promote the application of DEL technology in the field of new drug discovery.”
Richard Lerner, M.D. (1938-2021), Inventor of DEL technology & President of Scripps Research from 1987 to 2012
DELopen Services
The DELopen platform provides a one-stop Target-to-Hit service that enables the global academic community to pursue premium small molecule discoveries.
Protein Production
Quick Access | DSF
High Quality
Academic User Friendly
The DELopen compounds library is distributed in the form of a kit to approved researchers / institutions. According to protocols agreed by the compound suppliers, researchers can perform target selection experiments on their own using the kit. Institutions with their own DEL compounds library can also offer their library via the platform to researchers.
Free DELopen kit
Open Access
More than 4 Billion Compound Diversity
One-Stop DEL Experience
After completing target screening operations, researchers then conduct PCR and sequencing, and provide the results to the owner of the compound library. If positive results are obtained, both parties can further communicate and move on to the next stage of cooperation. If the library is provided by WuXi AppTec, WuXi can provide free PCR and sequencing services accompanied by relevant reports.
Downstream Validation
SPR/MST/nano
Machine Learning
Crystallization/Co- Crystallization
DELFinder, our DEL-related Database, contains all published DNA-encoded Library Technology related papers, patents, books, PhD theses, conference papers, news, clinical trial reports, etc. Researchers can quickly and accurately search the desired DEL literature or reports by filters such as source type, company/organization, etc., and get original sources through the provided links, so as to learn and track the research progress and latest applications of DEL technology.
WuXi AppTec DELopen Kit
The Kit
- 27 Libraries
- Diversity of compounds: 4.2 Billion
- 4 experimental conditions
Services with NO extra fee
- Sample processing at WuXi AppTec DEL platform
- NGS & Data deconvolution
- Data summary report
Our Services :
Post-selection processing: Sample quantitation by qPCR | PCR amplification
Next generation sequencing (NGS)
Data analysis & online platform: Decoding | Filter setting | Online data visualization platform
What is inside DELopen ?
DEL Libraries 10ul*4 | 4.2B compounds | 27 libraries
Buffer components | Imidazole
QC package
Returning tubes and stickers
Technical Support
User manual with step-by-step instructions
Tutorial videos on affinity selection
Teaching lab in Boston, US and Suzhou, China
DELopen Handbook
Screen billions of compounds in a small tube
About DELopen
Open Access to DEL For Data Sharing
DELopen User Manual
Guidelines for your DEL screening
