Comprehensive portfolio of drug resistant models representing clinically relevant mechanisms of resistance: 10+ cancer types 25+ key targets 30+ leading drugs 100+ resistant models Extensive validation data Our capabilities include cutting-edge bioinformatics and analytical techniques to enable a clear and in-depth understanding of resistance mechanisms View our AACR poster describing the establishment of a wide …Read More >

Offering a wide range of targeted oncology services and translational models.  Our comprehensive platform includes: in vitro biochemical, biophysical, and cell-based assays, including 600+ human cancer cell lines 70+ PDX-derived cell lines SPR, HTRF, ELISA, and FRET techniques ex vivo PD analysis, including: histopathology services NGS Flow cytometry Gene/protein expression analysis in vivo tumor models, …Read More >

Providing a comprehensive panel of large animal disease models across multiple species, including NHP, mini-pig, dog, and rabbit. Models for a wide range of indications, including autoimmune and inflammatory diseases Covering healthy animals, disease models, and animal biobank Multi-disciplinary read-outs (including clinical and pathology scoring, and medical imaging via MRI, X-ray, and endoscopy) Druggability assessment …Read More >

Comprehensive platform of over 40 disease models (including NHPs and other large animals), covering a wide range of indications and species Extensive panel of in vitro and ex vivo assays Validated, in-house models for autoimmune diseases, including: Alopecia areata Atopic dermatitis Delayed type hypersensitivity Experimental autoimmune encephalomyelitis Experimental sjögren’s syndrome Rheumatoid arthritis Systemic lupus erythematosus …Read More >

We offer an extensive panel of cutting-edge immune profiling and biomarker discovery services to support: Target discovery and validation Drug efficacy assessment Mechanism of action and PD studies Identification of predictive biomarkers, to support patient stratification Check out our comprehensive platform of immunology services View our panel of biomarker and immune profiling services

Comprehensive cell line screening assays integrated with downstream pharmacological services Cell panel  of 600+ human cancer cell lines for single agent or combinatory drug screening, covering 30+ cancer types 100+ mouse cell lines, across 20+ cancer types 95 PDX-derived cell lines 320+ CDX models, ready for use 1,400+ PDX models, for primary tumor cell line …Read More >

Multidisciplinary testing platforms that enable support to detect, develop, and validate biomarkers of cancer. End-to-end services in pathology, flow cytometry, and molecular biology techniques Rigorous quality management system, and well-established sample and data management procedures System biology analysis utilizing multidisciplinary testing platforms CAP-accredited clinical biomarker lab has been established since 2015 View our comprehensive platform …Read More >

Oncology & Immunology Services From the generation and characterization of genetically engineered animal models (GEAMs) to colony management and pre-clinical pharmacology research GEAM generation and characterization Full suite of in vitro testing assays Efficacy, toxicity, and PK/PD services Behavioral assessment platform Large in-house collection of GEAMs (KO/KI, mouse & rat) across multiple therapeutic areas, including: …Read More >

A comprehensive in vitro platform to accelerate cancer immunotherapy drug discovery: Binding & blocking assessment (via biophysical and biochemical assays, and flow cytometry) Immune cell activation (T cell, B cell, and NK cells) Immune cell suppression (MDSC and Treg suppressive assays) Immune T cell polarization and macrophage differentiation Antigen presentation/mixed lymphocyte reaction (including mouse allogenic …Read More >