WuXi AppTec scientists collaborated on a study to characterize a series of pyrroloquinoline derivatives that were designed and synthesized to understand the effect of various substitutions on human cytomegalovirus (HCMV) polymerase activity, antiviral activity, and hERG inhibition.  Results suggest that substitutions can be fine-tuned to reduce hERG inhibition while maintaining HCMV antiviral potency. The abstract …Read More >

WuXi AppTec scientists recently contributed to a research study which utilized an affinity purification mass spectrometry approach to identify nuclear interacting partners of Transcriptional Enhanced Associate Domain (TEAD) proteins.  The authors found a significant enrichment of interacting proteins linked to DNA damage, and they showed that depletion of TEAD transcription factors makes cells more susceptible …Read More >

To characterize the immunity profile of the most widely used delayed-type hypersensitivity (DTH) models, WuXi AppTec scientists built 2,4-dinitrofluorobenzene (DNFB) and oxazolone-induced DTH models in both BALB/c and C57BL/6 mice with robust ear thickness as the readout. Check out our comprehensive panel of services related to autoimmune and inflammatory diseases

We have established an enzalutamide-resistant (LNCaP AR-F877L mutation) KI prostate cancer model to support the development of next-generation therapeutics.  An LNCaP AR-F877L KI cell line was shown to be resistant to enzalutamide, and in vivo animal validation studies demonstrated that enzalutamide was not efficacious to prevent tumor growth using this drug-resistant model. Check out our …Read More >

As part of our autoimmune and inflammatory disease platform, we provide an extensive panel of monosodium urate (MSU) induced gout models, including: Air pouch gout models in mice and rats Articular injection induced gout models in mice, rats and rabbits View our wide range of in vitro assays and in vivo animal models related to inflammation …Read More >

Comprehensive portfolio of drug resistant models representing clinically relevant mechanisms of resistance: 10+ cancer types 25+ key targets 30+ leading drugs 100+ resistant models Extensive validation data Our capabilities include cutting-edge bioinformatics and analytical techniques to enable a clear and in-depth understanding of resistance mechanisms View our AACR poster describing the establishment of a wide …Read More >

Offering a wide range of targeted oncology services and translational models.  Our comprehensive platform includes: in vitro biochemical, biophysical, and cell-based assays, including 600+ human cancer cell lines 70+ PDX-derived cell lines SPR, HTRF, ELISA, and FRET techniques ex vivo PD analysis, including: histopathology services NGS Flow cytometry Gene/protein expression analysis in vivo tumor models, …Read More >

Providing a comprehensive panel of large animal disease models across multiple species, including NHP, mini-pig, dog, and rabbit. Models for a wide range of indications, including autoimmune and inflammatory diseases Covering healthy animals, disease models, and animal biobank Multi-disciplinary read-outs (including clinical and pathology scoring, and medical imaging via MRI, X-ray, and endoscopy) Druggability assessment …Read More >

Comprehensive platform of over 40 disease models (including NHPs and other large animals), covering a wide range of indications and species Extensive panel of in vitro and ex vivo assays Validated, in-house models for autoimmune diseases, including: Alopecia areata Atopic dermatitis Delayed type hypersensitivity Experimental autoimmune encephalomyelitis Experimental sjögren’s syndrome Rheumatoid arthritis Systemic lupus erythematosus …Read More >