Introduction： OncoWuXi Express will continue to keep you informed about updates to our online pharmacology model database (OncoWuXi Database), as well as our recent progress in preclinical research. In this issue, we showcase animal models related to Parkinson’s disease. https://onco.wuxiapptec.com Introduction Pathogenesis of Parkinson’s Disease Parkinson’s Disease (PD) is a widely prevalent neurodegenerative disorder globally. …Read More >

Introduction: Obesity has emerged as a pressing global public health issue, with its prevalence escalating at an unprecedented rate across the world. Body Mass Index (BMI) is a commonly used indicator to assess the degree of obesity. According to the World Obesity Atlas 2025, by 2030, over 2.9 billion adults globally will have a high …Read More >

Systemic lupus erythematosus (SLE) is a serious, chronic autoimmune disorder characterized by a heterogeneous clinical presentation, in which various organs and systems are affected in different ways and with varying degrees of severity.  SLE is characterized by an autoimmune reaction involving the innate and adaptive immune systems, including dendritic cells, T cells, and B cells. …Read More >

Introduction Endometriosis is a common gynecological condition that significantly impacts the health of women of reproductive age worldwide. Approximately 10% of reproductive-aged women and girls are affected by this condition [1]. As a complex estrogen-dependent disease, endometriosis can onset from menarche and persist until menopause. There is currently no cure; treatments primarily aim to alleviate …Read More >

Studies have demonstrated that obesity can promote cancer progression through mechanisms that include chronic low-grade inflammation.  Previous research with diet-induced obese animal models revealed that T cells in colorectal cancer are reduced in obesity. However, it is unclear how the tumor microenvironment changes under severe hyperglycemia and hyperlipidemia in different cancers. At AACR 2025, HD …Read More >

Metabolic Dysfunction-Associated Steatohepatitis (MASH) is a severe form of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). MASH is a growing public health concern due to its increasing prevalence, driven by factors like obesity, type 2 diabetes, and metabolic syndrome. MASH can progress to advanced liver scarring (fibrosis) and cirrhosis, increasing the risk of liver cancer and …Read More >

Precision-cut tissue slices (PCTS) are an effective ex vivo model for studying human diseases, including those involving the tissue microenvironment. PCTS represent a more in vivo-like model for studying complex interactions within tissues compared to cell cultures or in vitro systems. PCTS preserve the original tissue structure, including the extracellular matrix (ECM), immune components, and …Read More >

Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is a key mediator of non-canonical Wnt signaling and plays a critical role in cancer progression. ROR1 is selectively and highly expressed in various solid tumors and hematological malignancies, while absent in normal adult tissue, making it a promising target for cancer therapy. Currently, there is a need …Read More >

Natural killer (NK) cells play a crucial role in the immune system and can recognize and kill cancer cells. Research in this area is focused on strategies for enhancing NK cell activity in tumor immunotherapy. These strategies include using monoclonal and multi-specific antibodies, as well as immune modulator molecules like cytokines, to redirect and stimulate …Read More >