THERAPEUTIC AREAS Archives

Simultaneous In Vitro Profiling of Anticancer Efficacy and Toxicity

Many oncology drug candidates with promising preclinical activity ultimately fail because safety liabilities emerge too late in development. An integrated...

EpCAM-CD3 BsAb-Encoding mRNA Suppresses Lung Tumors

Bispecific antibodies have emerged as an important modality in oncology, although their broader application can be limited by manufacturing complexity...

Synthetic-Lethality Screening with PARP1 inhibition

PARP1 plays a central role in DNA repair and is a well-established target across multiple cancer types. Understanding the vulnerabilities...

Drug-Resistant KRAS G12D Lung Cancer Models

KRAS G12D inhibitors continue to advance, but treatment resistance remains an important challenge. Understanding how that resistance develops is critical...

A Novel Preclinical Mouse Model of Neutrophilic Asthma

Neutrophilic asthma remains one of the most challenging forms of asthma to study, with limited preclinical models available to support...

A Novel Murine Model of MetALD for Therapeutic Drug Evaluation

Metabolic dysfunction-associated alcohol-related liver disease (MetALD) presents unique challenges for preclinical drug development, requiring models that capture the combined effects...

HPV18 Tumor Models for Cancer Vaccines and Immunotherapy

OncoWuXi Express will continue to keep you informed of updates to our online pharmacology model database (OncoWuXi Database) and our...

Semaglutide in Substance Use Disorders: Addiction Models

Substance Addiction Models and Pharmacodynamic Evaluation of Semaglutide in the Treatment of Substance Use Disorders OncoWuXi Express will continue to...

Enhancing Treatment of MASH with Combination Therapies

Metabolic dysfunction-associated steatohepatitis (MASH) remains a significant global health challenge, driven by a complex interplay of lipid dysregulation, inflammation, and...

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