Knowledge Library
Nephropathy Research Platform
Kidney diseases are complex conditions caused by a variety of factors, including autoimmune diseases, metabolic disorders, infections, drug side effects, and genetics. Kidney diseases can lead to a range of complications, including kidney failure, anemia, electrolyte imbalances, and nerve damage, thereby affecting the quality of life. To drive breakthroughs in this critical field, WuXi AppTec …Read More >
Women’s Health Platform
Women’s health care is crucial not only for the well-being of individual women but also for the health and prosperity of families and communities. Despite significant medical advancements, there remains a concerning gap in the availability of effective drugs for common women-related diseases such as endometriosis, menopause syndromes, polycystic ovary syndrome (PCOS), and various forms …Read More >
Fibrosis Disease: Mechanisms, Therapeutic Targets, and Animal Models
Introduction: Fibrosis is a pathological process characterized by the excessive deposition of extracellular matrix (ECM) within an organ, leading to significant damage to its structure and function, which can potentially impact multiple organs such as the lungs, liver, heart, kidneys, and skin (Fig.1). Notable examples of fibrotic diseases include idiopathic pulmonary fibrosis (IPF), liver cirrhosis, …Read More >
Targeting FAK Improves the Tumor Uptake of ADCs
Antibody-drug conjugates (ADCs), exemplified by HER2-targeted Enhertu and TROP2-targeted Trodelvy, have demonstrated significant therapeutic potential in cancers. However, a subset of patients remains refractory to ADC treatment. WuXi AppTec contributed to a research article which demonstrated that excessive cancer-associated fibroblasts (CAFs) can form a fibrotic barrier within a tumor microenvironment, impeding the tissue uptake of …Read More >
BRCA2 Deficient DLD-1 Model
BRCA1 and BRCA2 proteins are key components of the homologous recombination repair pathway for repairing double-stranded DNA breaks. Mutations in BRCA genes can significantly increase the risk of certain cancers such as breast, ovarian, pancreatic, and prostate cancer. To mimic the effects of BRCA2 deficiency in humans, WuXi Biology has constructed a BRCA2 deficient mouse …Read More >
Discovery of GuaB Inhibitors for the Treatment of Tuberculosis
Tuberculosis is the leading cause of death from an infectious disease and is caused by Mycobacterium tuberculosis (MTB). Inosine-5′-monophosphate dehydrogenase (GuaB) is an enzyme that performs the rate-limiting step in the de novo biosynthesis of guanine, which is critical for growth of bacteria, including MTB. The development of a novel antibiotic that inhibits GuaB could …Read More >
OncoWuXi Express: Evaluation of T Cell Engagers
Introduction: OncoWuXi Express will continue to keep you informed about updates to our online tumor model database (OncoWuXi Database), as well as our recent progress in cancer and autoimmune research. In this issue, we would like to share with you our preclinical pharmacological evaluation platform for T cell engagers. https://onco.wuxiapptec.com Introduction T-cell engagers (TCEs) are …Read More >
Metabolic Disease Services Platform
Metabolic diseases are considered to arise from multiple factors (such as genetics, diet, age, and environmental factors) and often affect various organs throughout the body. No single cause is solely responsible for these disorders. To support research in this area, WuXi AppTec offers a comprehensive platform of in vitro and in vivo services. Our capabilities …Read More >
Small Molecule Reactivator of p53 Y220C Mutant
Mutant p53 is one of the most attractive targets for new anti-cancer drugs. Although traditionally regarded as difficult to drug, several new strategies have recently become available for targeting the mutant protein. One of the most promising of these involves the use of low molecular weight compounds that promote refolding and reactivation of mutant p53 …Read More >