Knowledge Library

KRAS-related Genetically Engineered Cell Lines and In Vivo Models

KRAS mutant proteins that drive cancer development are highly similar in sequence and structure. Direct inhibitors are most likely to bind to the catalytic domain of KRAS. However, recent studies have found that KRAS mutants can also be targeted by heterogeneous sites, to develop covalent inhibitors of KRAS mutants. The discovery of inhibitors that selectively …Read More >

Resource Type: Latest Science Presentation
Resource Topic: Biochemical Assays Biophysical Assays Cell-based Assays Cells and Protein Science Hit Finding Hit-to-Lead Lead Optimization Oncology Small Molecules Tumor Models

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Targeted Protein Degradation

WuXi AppTec utilizes state-of-the-art techniques to support drug discovery teams focused on targeted protein degradation. Our services include a broad range of ligand-finding methods, such as DEL, fragment screening, ASMS, and virtual screening. We provide custom linker design and complex synthesis for new linkers and E3 ligase ligands. To support lead optimization efforts, our platform …Read More >

Resource Type: Brochure Latest Science
Resource Topic: Biochemical Assays Biophysical Assays Cell-based Assays Mass Spectrometry-based Assays Oncology Small Molecules Structural Biology Targeted Protein Degradation

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In Vitro Imaging Services

Offering a comprehensive platform of in vitro imaging-based assays to screen compounds for cancer, inflammation, and autoimmune diseases. Our services include: Imaging assays for cell proliferation and apoptosis Imaging assays for cell cycle analysis Cell-based functional assays, including: Antibody internalization Live-cell immunocytochemistry Cellular movement and morphology monitoring Assays for 3D cell models, including: Spheroid growth …Read More >

Resource Type: Latest Science Presentation
Resource Topic: Biomarkers Cell-based Assays Hit-to-Lead Lead Optimization Oncology Phenotypic Assays Target Identification and Validation

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CDK4/6 Inhibitor Resistant Breast Cancer Models

Leverage our extensive panel of CDK4/6 inhibitor resistant breast cancer models, including:  In vitro induced Palbociclib resistant MCF-7 cell line In vivo induced Palbociclib resistant MCF-7 model In vivo induced Abemaciclib resistant MCF-7 model In vivo induced Ribociclib resistant MCF-7 model

Resource Type: Latest Science Presentation
Resource Topic: Cell-based Assays Oncology Target-Specific Assays Tumor Models

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Ligand Finding and Chemistry Workflows for Targeted Protein Degradation

This webinar will focus on aspects related to PROTAC discovery and chemistry workflows, such as ligand finding strategies, synthesis optimization, and linker design. Successful development of bifunctional molecules requires a deep understanding of multiple processes, including biophysical events which dictate induced proximity and how technologies such as DNA-encoded libraries (DEL) can be leveraged to identify …Read More >

Resource Type: Webinar
Resource Topic: Autoimmune and Inflammatory Diseases Biophysical Assays Cardiovascular & Metabolic Diseases Central Nervous System & Pain Discovery Chemistry DNA-Encoded Library (DEL) Hit Finding Hit-to-Lead Lead Optimization Oncology Small Molecules Structural Biology Target-Specific Assays Targeted Protein Degradation

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Biological Characterization and Development Workflows for Targeted Protein Degradation

This webinar will focus on PROTAC biology workflows, such as in vitro screening assays, in vivo testing, and optimization of DMPK properties. Topics will include the best use of biochemical assays to measure binary/ternary complex formation, cell-based assays to assess target engagement and degradation, strategies for enhancing drug delivery and formulation, and PK/PD evaluation of …Read More >

Resource Type: Webinar
Resource Topic: Autoimmune and Inflammatory Diseases Biochemical Assays Cardiovascular & Metabolic Diseases Cell-based Assays Central Nervous System & Pain Hit-to-Lead in vitro biology in vivo Pharmacology Lead Optimization Oncology Small Molecules Target Identification and Validation Target-Specific Assays Targeted Protein Degradation

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OncoWuXi Newsletter December 2022

Resource Type: Latest Science Newsletter
Resource Topic: Autoimmune and Inflammatory Diseases Biochemical Assays Biomarkers Candidate Selection Cell-based Assays CRISPR/Cas9 DRUG DISCOVERY AND INNOVATION Hit Finding Hit-to-Lead Immunology Lead Optimization Oncology Phenotypic Assays Rare Diseases Target Identification and Validation Tumor Models

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Discovery Newsletter Special New Year Edition 2023

Resource Type: Latest Science Newsletter
Resource Topic: Biophysical Assays Central Nervous System & Pain Discovery Chemistry DNA-Encoded Library (DEL) Hit-to-Lead in silico services Lead Optimization Quantum Mechanics Small Molecules Target Identification and Validation Targeted Protein Degradation

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WuXi AppTec in vitro Neuroscience Services

Neurological disorders, such as neurodegenerative diseases, epilepsy, chronic pain, psychiatric disorders, are one of today’s largest unmet medical needs. However, due to poor disease and target understanding, Neuroscience drug discovery can be very challenging. An open access research platform with dedicated neuroscience specialists and integrated services will be an ideal partner throughout your drug discovery …Read More >

Resource Type: Brochure
Resource Topic: Antibodies Biochemical Assays Biomarkers Cell-based Assays Cells and Protein Science Central Nervous System & Pain Hit Finding Hit-to-Lead in vitro biology Lead Optimization Phenotypic Assays Rare Diseases Safety and Early Toxicity Small Molecules Target Identification and Validation

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