in vitro biology Archives - Page 2 of 16

Asthma Services Platform

Asthma is a chronic, lower airway disease characterized by persistent inflammation and hyperreactivity. Asthma involves a complex immune response, with...

Production and Characterization of Protein Biologics

At the 2024 Protein & Antibody Engineering Summit (PEGS) Europe, Crelux presented a poster highlighting its drug discovery platform for...

Targeted Protein Degradation Platform

Targeted protein degradation (TPD) technology has become one of the most promising methods to remove specific disease-related proteins using cellular...

Toxicology Profile of a Novel GLP-1 Receptor Agonist

Glucagon‐like peptide‐1 (GLP-1) receptor agonists have emerged as promising therapeutic options for addressing type‐2 diabetes, obesity, and related conditions. However,...

Evaluation of Bispecific Antibodies in NHPs

In recent years, bispecific antibodies (BsAbs) have emerged as a novel strategy in tumor immunotherapy. BsAbs combine two distinct antigen...

USP7 Inhibitors Reveal a Differentiated Mechanism of p53-Driven Anti-Cancer Activity

Ubiquitin-speciﬁc protease 7 (USP7) is a deubiquitinating enzyme that cleaves ubiquitin from a range of substrates, shielding them from degradation...

ErbB Receptor Tyrosine Kinase Platform

The ErbB family of receptor tyrosine kinases are involved in key cellular functions, including cell growth and survival. ErbB family...

Phosphatidylinositol Kinases: Structural Biology Services

Within the phosphatidylinositol 3-kinase (PI3K) family, the heterodimer comprising the p110-α catalytic and p85-α regulatory subunits (encoded by PIK3CA and...

Janus Kinases: Structural Biology Services

The inhibition of the JAK/STAT signaling pathway is a promising approach for the treatment of cancers and inflammatory diseases. To...

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