Knowledge Library

Cancer Immunotherapy and the Application of In Vitro Immunoassays in Drug Development

Resource Type: Webinar
Resource Topic: Antibodies, Autoimmune and Inflammatory Diseases, Biochemical Assays, Cell-based Assays, Hit-to-Lead, Immunology, Lead Optimization, Oncology, Phenotypic Assays, Small Molecules, Target Identification and Validation, Target-Specific Assays

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Novel Peptide Hit Identification and Lead Generating Strategies for Drug Discovery

Resource Type: Webinar
Resource Topic: Cells and Protein Science, Hit-to-Lead, in vitro biology, Lead Optimization, Small Molecules, Target Identification and Validation

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Optimizing Drug Discovery Pipelines with Biophysical Methods

Resource Type: Webinar
Resource Topic: Antibodies, Biochemical Assays, Biomarkers, Biophysical Assays, Cell-based Assays, DNA-Encoded Library (DEL), Fragment-Based Drug Discovery, Hit Finding, Hit-to-Lead, Mass Spectrometry-based Assays, Oncology, Phenotypic Assays, Screening Libraries, Small Molecules, Structural Biology, Target Identification and Validation, Target-Specific Assays, Targeted Protein Degradation

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Aug 2021: Wuxi AppTec immune profiling in drug discovery and CLDN18.2-related tumor models.

Resource Type: Newsletter
Resource Topic: Candidate Selection, Cell-based Assays, Hit-to-Lead, Immunology, Lead Optimization, Oncology, Tumor Models

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Validation of GVHD in mouse model for preclinical efficacy screen

AACR Annual meeting 2021 Na Xu, Ya Zhang, Rou Xie, Lijun Jia, Yingying Cai, Qing Lin Oncology and Immunology Unit, WuXi AppTec, 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China Background Bone marrow transplantation has been successfully and widely used to treat diseases such as leukemia and lymphomas. However, the complication Graft …Read More >

Resource Type: Poster
Resource Topic: Biochemical Assays, Biomarkers, Cell-based Assays, Cells and Protein Science, Chemical Biology and Proteomics, in vivo Pharmacology, Oncology, Tumor Models

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Engineered cell line panel complemented with in vivo models to enable next-generation target therapy discovery in cancer

 AACR Annual meeting 2021   Authors: Zhixiang Zhang1, Feifei Fan2, Xiaohe Shi2, Xiangyang Zuo2, Qingyang Gu2, Qunsheng Ji1. 1 WuXi AppTec, Shanghai, China; 2 WuXi AppTec, Jiangsu, China Corresponding Author: Qunsheng Ji. Email: ji_qunsheng@wuxiapptec.com   Background  Many cancer types are driven by specific gene aberrances, like gene fusions, mutations and copy number changes. It has led to …Read More >

Resource Type: Poster
Resource Topic: Biomarkers, Cell-based Assays, Oncology, Phenotypic Assays, Target Identification and Validation, Tumor Models

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Drug Hunter: Discovering New Frontiers in Cancer Treatments & Beyond

INNOVATION THAT MATTERS By Rich Soll, Senior Advisor, Strategic Initiatives at WuXi AppTec (@richsollwx) As a self-proclaimed drug hunter, Phil Jones is on a mission to identify the next generation of cancer medicines that improve the lives of patients with cancer. He leads a multi-disciplinary team of scientists at The University of Texas MD Anderson Cancer Center’s Institute …Read More >

Resource Type: Article
Resource Topic: Biomarkers, CAR-T Cell, Cells and Protein Science, Chemical Biology and Proteomics, DRUG DISCOVERY AND INNOVATION, Hit Finding, in vitro biology, in vivo Pharmacology, Oncology, Phenotypic Assays, Small Molecules, Target Identification and Validation

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Faster with high-speed fragment screening — Accelerate your drug discovery campaign

In the past, thousands of proteins were considered undruggable. The restricted number of chemical entities available and classical methods limited the exploration of this undevelopable area. Today, the combination of novel chemical modalities and advanced technical approaches has resulted in new clinical candidates from previously undruggable targets. To accelerate your drug discovery campaign, WuXi AppTec´s …Read More >

Resource Type: Article, Blog, Case Study
Resource Topic: Biochemical Assays, Biophysical Assays, Fragment-Based Drug Discovery, Hit Finding, Hit-to-Lead, Immunology, Lead Optimization, Small Molecules, Structural Biology

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Unlocking the potential of DEL | Inspire Hit Discovery

March 4, 2020 – By going commercial, DNA Encoded Library (DEL) technology facilitates rapid discovery and provides access to more chemical entities at lower cost. Over the years, DEL has become a disruptive drug discovery technology in comparison to traditional high-throughput screening (HTS) where it allows expedition of early stage drug discovery. However, DEL platforms don’t succeed …Read More >

Resource Type: Article
Resource Topic: Biophysical Assays, DNA-Encoded Library (DEL), Hit Finding, Small Molecules, Target Identification and Validation

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Resource Topics
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