Knowledge Library

Discovery Chemistry Outsourcing Services

Global Leader in Discovery Chemistry Outsourcing Services Based on FTE (Full Time Equivalent) Model | Customization to Client’s Synthetic Chemistry with high productivity, quality, speed, and reliability Project Management:  we manage project timelines and compound flow Medicinal Chemistry: we provide compound design and project management Integrated Projects from targets to hits to leads to preclinical …Read More >

Resource Type: Brochure
Resource Topic: Candidate Selection Chemical Biology and Proteomics Discovery Chemistry Hit-to-Lead Lead Optimization Mass Spectrometry-based Assays Quantum Mechanics Small Molecules

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Translational Oncology

Biomarker discovery Mouse clinical trial 61 PDX-derived primary cancer cell lines Drug-resistant xenograft models Combination therapy platform including radiation World leading genome sequencing and bioinformatics capability

Resource Type: Brochure
Resource Topic: Biomarkers Candidate Selection Cell-based Assays Cells and Protein Science Chemical Biology and Proteomics Lead Optimization Oncology Phenotypic Assays Tumor Models

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Patient-Derived Xenograft (PDX) Tumor Models

One of the largest collection of Patient-Derived Xenograft (PDX) Tumor Models in Asia with gene expression/mutation profiling 1200 PDX models Collection of PDX models prevalent in Asia 800+ PDX models with genetic profiling Searchable online database with mobile APP Integrated online database for PDX, CDX & Syngeneic tumor models with mobile App PDX with oncogene …Read More >

Resource Type: Brochure
Resource Topic: Biomarkers in vivo Pharmacology Lead Optimization Tumor Models

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Immuno-Oncology Services

Immuno-oncology Platform An outstanding platform to enable cancer immunotherapy with one stop service: Immunological function assessment TIL analysis – Flowcytometry, Multiplex IF and Cytex Animal models – Syngeneic and humanized models Immune profiling by NGS – Single Cell RNAseq, Mutation burden and TCR/BCR repertoire Clinical biomarker services – CAP certification and GCP compliance

Resource Type: Brochure
Resource Topic: Antibodies Autoimmune and Inflammatory Diseases Biomarkers Cell-based Assays Cells and Protein Science Hit-to-Lead Immunology in vivo Pharmacology Lead Optimization Oncology Phenotypic Assays Target Identification and Validation Target-Specific Assays Tumor Models

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Cell Line-Derived Xenograft (CDX) Tumor Models

A large collection of cell line-derived xenograft (CDX) tumor models 215 validated models, SOC data available World leading imaging based orthotopic/metastatic CDX platform 28 models covering 16 tumor types

Resource Type: Brochure
Resource Topic: in vivo Pharmacology Lead Optimization Oncology Oncolytic Viruses Small Molecules Target Identification and Validation Tumor Models

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WuXi Oncology and Immuno-Oncology Services

Integrated Oncology and Immuno-oncology Platform to Enable Translational Science from Drug Discovery to Clinical Biomarker Oncology Services CRISPR/Cas9 Gene Editing In Vitro Assay and HTS Tumor models Tumor Cell Panel and Screening Immunology and Immuno-oncology Platform Clinical Biomarker Immunology Services Ligand-receptor binding assays Cellular functional assays Assays for innate immunity pathways: macrophage, MDSC, NK, DC, …Read More >

Resource Type: Brochure
Resource Topic: Antibodies Biochemical Assays Biomarkers Cell-based Assays Cells and Protein Science Chemical Biology and Proteomics Gene Therapies High-throughput screening (HTS) Hit-to-Lead Immunology in vitro biology in vivo Pharmacology Lead Optimization Oncology Screening Libraries Small Molecules Target Identification and Validation Target-Specific Assays Targeted Protein Degradation Tumor Models

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Virology and Viral Vector Platforms

WuXi virology platforms: Immunology, Anti viral, Viral Vector, Oligo-nucleotide, Clinical and Immunology in vitro screening and profiling in vivo efficacy clinical virology Liver-specific viruses | Respiratory viruses | Herpes viruses | Other viruses

Resource Type: Brochure
Resource Topic: Biochemical Assays Biomarkers Candidate Selection CAR-T Cell Cell-based Assays Cells and Protein Science in vivo Pharmacology in vivo Toxicology Infectious Diseases Lead Optimization Oncolytic Viruses Phenotypic Assays Safety and Early Toxicity

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WuXi AppTec in vitro Safety Pharmacology Profiling

Comprehensive in vitro Off-target Screening Services WuXi Discovery Biology provides in vitro Safety Pharmacology services to identify potential off-target liabilities. Three choices can be selected: WuXi Biology Mini Safety Panel “WuXi Mini 44” A primary safety panel, which is designed to identify compounds with the highest risk because it contains targets associated with the most …Read More >

Resource Type: Brochure
Resource Topic: Biochemical Assays Cell-based Assays Lead Optimization Safety and Early Toxicity Target-Specific Assays

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in vitro Toxicity Services

Identify potential liability issues in early stages of drug discovery Cardiotoxicity hERG and other ion channel test Stem cell derived cardiomyocyte test on MEA General Cytotoxicity Cell Viability Assay Apoptosis Assay CellTox ™ Green Cytotoxicity Assay ApoTox Glo ™ Triplex Assay Mitochondrial ToxicityMitochondrial Membrane Potential Assay Mitochondrial Reactive Oxygen Species (ROS) Assay Oxygen Consumption Assay: …Read More >

Resource Type: Brochure
Resource Topic: Biochemical Assays Cell-based Assays Hit-to-Lead in vitro biology Lead Optimization Safety and Early Toxicity

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