Knowledge Library

OncoWuXi Express: PSMA Overexpressing PC3 Tumor Model

Introduction: OncoWuXi Express will continue to keep you informed about updates to our on-line tumor model database (OncoWuXi Database), as well as our recent progress in cancer and autoimmune research. In this issue, we would like to share with you the newly established PSMA-overexpressing PC3 prostate cancer model. https://onco.wuxiapptec.com Globally, prostate cancer stands not only …Read More >

Resource Type: Article Blog
Resource Topic: Oncology Tumor Models

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AACR 2024 Posters: Sneak Peek

AACR 2024 Sneak Peek | Your All-In-One Guide to WuXi Biology’s Latest Advances in Cancer Research The American Association for Cancer Research (AACR) Annual Meeting 2024, one of the largest global cancer research conferences, will take place from April 5 to 10 at the San Diego Convention Center. This year, WuXi Biology has been selected …Read More >

Resource Type: Article Blog
Resource Topic: CAR-T Cell Oncology Oncolytic Viruses Tumor Models

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T-DXd Resistant Tumor Models with ABCG2

Antibody‒drug conjugates (ADCs), which combine the advantages of monoclonal antibodies with precise targeting and payloads, show great potential as cancer therapies.  However, primary and secondary resistance is frequently observed, and development of next generation ADCs necessitates the establishment of resistant tumor models.  One mechanism of resistance involves efflux of the ADC payload by the transporter …Read More >

Resource Type: Presentation
Resource Topic: Antibody Drug Conjugate Oncology Tumor Models

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OncoWuXi Express: Adenovirus Vaccine AD5-HPV Inhibits Tumor Growth by Stimulating Immunity

OncoWuXi Express will continue to keep you informed about updates to our on-line tumor model database (OncoWuXi Database), as well as our recent progress in cancer and autoimmune research. In this issue, we share with you our experience in the establishment and antitumor efficacy evaluation of adenovirus vaccine AD5-HPV. https://onco.wuxiapptec.com Introduction: Adenoviruses (Ad) are non-enveloped …Read More >

Resource Type: Article Blog Case Study
Resource Topic: Oncology Tumor Models

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Addition of Covalent Warhead and DEL-Generated Hit Fragmentation Empower FBDD

Fragment-based drug discovery (FBDD) is one of the most well-developed approaches for projects starting from small, low-affinity compounds.  At the SLAS 2024 meeting in Boston, WuXi AppTec presented a poster reporting on the assembly of a covalent fragment library that is suited to tackle protein targets via serine, lysine, and cysteine residues. In a case …Read More >

Resource Type: Latest Science Poster
Resource Topic: DNA-Encoded Library (DEL) Fragment-Based Drug Discovery Hit Finding Hit-to-Lead Lead Optimization Small Molecules

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Establishment of EGFR TKI-Resistant Tumor Models

Despite improvement in clinical outcomes observed with the use of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (EGFR-TKIs), long-term prognosis remains unfavorable due to the development of either intrinsic or acquired resistance.  Understanding the mechanisms underlying this resistance is vital for designing strategies to address this challenge, and one approach involves the establishment of …Read More >

Resource Type: Latest Science Poster
Resource Topic: Oncology Tumor Models

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iMN041: Prodrug with a Unique Antitumor Immune Response

WuXi AppTec scientists contributed to a research article in the journal Translational Medicine Communications which characterized the antitumor immune responses generated by iMN041, a prodrug of a DNA methyl transferase/ribonucleotide reductase inhibitor.  This study also assessed the efficacy of iMN041 in mouse xenografts of human clear cell renal cell cancer, pancreatic cancer, and triple negative …Read More >

Resource Type: Latest Science Publication
Resource Topic: Cell-based Assays Immunology Oncology Tumor Models

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DNA-Compatible Cyclizations

The recent publication in the journal Organic Letters, ‘DNA-Compatible Cyclization Reaction to Access 1,3,4-Oxadiazoles & 1,2,4-Triazoles‘ by our WuXi Biology DEL team, introduces two novel DNA-compatible reactions, successfully incorporating bioactive cores 1,3,4-oxadiazoles and 1,2,4-triazoles into the DEL library. These cores are reported to show broad ranges of biological activities, such as antiviral, anti-inflammatory, anticancer, antifungal, …Read More >

Resource Type: Latest Science Publication
Resource Topic: Discovery Chemistry DNA-Encoded Library (DEL) Small Molecules

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EML4-ALK Cell Lines and In Vivo Models

The EML4-ALK fusion gene occurs in approximately 5% of non-small-cell lung cancers (NSCLCs), making this oncogene an important drug target.  The development of ALK tyrosine kinase inhibitors (ALK-TKIs) has been a major advance in treating NSCLC with this fusion gene, but acquired resistance to ALK-TKIs ultimately limits their use.  To support the development of next-generation …Read More >

Resource Type: Latest Science Presentation
Resource Topic: Cells and Protein Science Oncology Tumor Models

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