Knowledge Library

OncoWuXi Express: Animal Models of Parkinson’s Disease

Introduction: OncoWuXi Express will continue to keep you informed about updates to our online pharmacology model database (OncoWuXi Database), as well as our recent progress in preclinical research. In this issue, we showcase animal models related to Parkinson’s disease. https://onco.wuxiapptec.com Introduction Pathogenesis of Parkinson’s Disease Parkinson’s Disease (PD) is a widely prevalent neurodegenerative disorder globally. …Read More >

Resource Type: Article, Blog
Resource Topic: Central Nervous System & Pain, in vivo Pharmacology

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ADC Development: Preclinical Pharmacology Essentials

Antibody-drug conjugates (ADCs) are increasingly demonstrating their value in cancer treatment, especially in combination therapies and for targeting resistant cancer cell populations.  The ability of ADCs to deliver highly potent cytotoxic payloads directly to cancer cells that express a target antigen makes them a promising approach for targeted therapy.  However, the complex structure and mechanism …Read More >

Resource Type: Video
Resource Topic: Antibody Drug Conjugate, Tumor Models

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Innovative R&D Strategies for Peptide Drugs in Obesity Treatment

Introduction: Obesity has emerged as a pressing global public health issue, with its prevalence escalating at an unprecedented rate across the world. Body Mass Index (BMI) is a commonly used indicator to assess the degree of obesity. According to the World Obesity Atlas 2025, by 2030, over 2.9 billion adults globally will have a high …Read More >

Resource Type: Article, Blog
Resource Topic: in vivo Pharmacology, Metabolic Diseases, Peptides

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Systemic Lupus Erythematosus Animal Models

Systemic lupus erythematosus (SLE) is a serious, chronic autoimmune disorder characterized by a heterogeneous clinical presentation, in which various organs and systems are affected in different ways and with varying degrees of severity.  SLE is characterized by an autoimmune reaction involving the innate and adaptive immune systems, including dendritic cells, T cells, and B cells. …Read More >

Resource Type: Presentation
Resource Topic: in vivo Pharmacology, Rare Diseases

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Endometriosis: Animal Models as Tools to Accelerate New Therapeutics

Introduction Endometriosis is a common gynecological condition that significantly impacts the health of women of reproductive age worldwide. Approximately 10% of reproductive-aged women and girls are affected by this condition [1]. As a complex estrogen-dependent disease, endometriosis can onset from menarche and persist until menopause. There is currently no cure; treatments primarily aim to alleviate …Read More >

Resource Type: Article, Blog
Resource Topic: Autoimmune and Inflammatory Diseases, in vivo Pharmacology

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Severe Hyperglycemia and Hyperlipidemia Alter Tumor Growth and Immune Profiles in Syngeneic Tumor Models

Studies have demonstrated that obesity can promote cancer progression through mechanisms that include chronic low-grade inflammation.  Previous research with diet-induced obese animal models revealed that T cells in colorectal cancer are reduced in obesity. However, it is unclear how the tumor microenvironment changes under severe hyperglycemia and hyperlipidemia in different cancers. At AACR 2025, HD …Read More >

Resource Type: Latest Science, Poster
Resource Topic: Metabolic Diseases, Tumor Models

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Alterations in Energy Metabolism and Lipogenesis in GIPR/GLP-1R Agonist-Treated MASH Mice

Metabolic Dysfunction-Associated Steatohepatitis (MASH) is a severe form of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). MASH is a growing public health concern due to its increasing prevalence, driven by factors like obesity, type 2 diabetes, and metabolic syndrome. MASH can progress to advanced liver scarring (fibrosis) and cirrhosis, increasing the risk of liver cancer and …Read More >

Resource Type: Latest Science, Poster
Resource Topic: in vivo Pharmacology, Liver Diseases, Metabolic Diseases

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Novel ROR1 Antibody with High Specificity and Sensitivity for Predictive Biomarker Detection

Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is a key mediator of non-canonical Wnt signaling and plays a critical role in cancer progression. ROR1 is selectively and highly expressed in various solid tumors and hematological malignancies, while absent in normal adult tissue, making it a promising target for cancer therapy. Currently, there is a need …Read More >

Resource Type: Latest Science, Poster
Resource Topic: Biomarkers, Oncology

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Development of NK Humanized Mouse Models

Natural killer (NK) cells play a crucial role in the immune system and can recognize and kill cancer cells. Research in this area is focused on strategies for enhancing NK cell activity in tumor immunotherapy. These strategies include using monoclonal and multi-specific antibodies, as well as immune modulator molecules like cytokines, to redirect and stimulate …Read More >

Resource Type: Latest Science, Poster
Resource Topic: Immunology, in vivo Pharmacology, Oncology, Tumor Models

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Resource Topics
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