Knowledge Library

Discovery of CVN636: A Highly Potent, Selective, and CNS Penetrant mGluR7 Allosteric Agonist

The metabotropic glutamate receptor mGluR7 is widely expressed throughout the CNS and has been implicated in numerous CNS disorders.  WuXi AppTec scientists recently contributed to a study which led to the identification, optimization, and characterization of a highly potent, novel mGluR7 allosteric agonist, designated CVN636.  The authors show that CVN636 has high selectivity toward mGluR7, …Read More >

Resource Type: Latest Science Publication
Resource Topic: Biochemical Assays Central Nervous System & Pain High-throughput screening (HTS) Hit Finding Hit-to-Lead Lead Optimization Small Molecules

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OncoWuXi Express: In vitro and in vivo evaluation of an mRNA-encoded bispecific antibody (EpCAM/CD3)

Introduction Nucleic acid therapies can regulate the expression level or activity of disease-related targets at the genetic level, offering advantages such as a wide target range, programmability, and rapid iteration.  However, the wide application of nucleic acid drugs still faces many challenges, including delivery efficiency and off-target effects. To address these challenges, the Oncology-Immunology team …Read More >

Resource Type: Article Case Study
Resource Topic: Antibodies Cell-based Assays Oncology Tumor Models

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Recent Advances in Peptide Drug Discovery

Peptides, and in particular macrocyclic peptides, are well known for their ability to disrupt protein-protein interactions (PPIs).  In this webinar, learn how DNA encoded library (DEL) screening can be used to discover peptide macrocycles that disrupt PPIs.  Our speakers present a case study using the oncoprotein murine double minute 2 (MDM2). We will also highlight the …Read More >

Resource Type: Webinar
Resource Topic: Biophysical Assays DNA-Encoded Library (DEL) Hit Finding

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Screening Methods to Identify RNA-Targeting Small Molecules

RNA molecules are promising drug targets due to their genomic prevalence, disease involvement, and druggable complex structures. Successful examples include RNA-targeting small molecule drugs for spinal muscular atrophy (SMA), with on-going efforts in other RNA-related diseases. Here, Dr. Zhifeng Yu presents our toolbox for discovering RNA-targeting small molecules, with a focus on unique DNA-encoded libraries …Read More >

Resource Type: Webinar
Resource Topic: Biophysical Assays DNA-Encoded Library (DEL) Hit Finding Mass Spectrometry-based Assays

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Atopic Dermatitis Models

Atopic dermatitis (AD) is the most common, chronic inflammatory skin disease.  To support drug discovery research in this area, WuXi AppTec offers a broad platform of validated, in vivo AD models.  Our panel includes DNCB, DNFB, and MC903-induced AD models.  Study readouts include histopathology scoring and measurements of serum IgE levels, transepidermal water loss, and …Read More >

Resource Type: Latest Science Presentation
Resource Topic: Autoimmune and Inflammatory Diseases in vivo Pharmacology

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Metastasis-Related In Vitro Assays and Xenograft Models

Cell migration, invasion, and adhesion are pivotal steps in cancer metastasis.  To support research in this field, WuXi AppTec offers in vitro transwell migration and invasion assays using multiple cell types for assessing cell migratory behavior.  In addition, our in vivo metastasis panel includes a broad range of brain, bone, and liver xenograft models covering …Read More >

Resource Type: Latest Science Presentation
Resource Topic: Cell-based Assays Oncology Tumor Models

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Jurkat Reporter Cell Lines for Immunotherapy Drug Screening

WuXi AppTec offers Jurkat reporter cell lines for immunotherapy drug screening.  Our platform includes CD8+, TCR knockout and CD16-expressing Jurkat-NFAT-Luc reporter cell lines, and validated assays (using co-cultures of Raji or A375 tumor cells) to evaluate the activity of CARs, TCRs, and bispecific antibodies.  Leverage our portfolio of reporter cell lines to accelerate your research! …Read More >

Resource Type: Latest Science Presentation
Resource Topic: Cell-based Assays Cells and Protein Science Immunology Oncology

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Discovery of Novel GST Inhibitors Identified from a DNA-Encoded Library

WuXi AppTec scientists recently contributed to a study which led to the discovery and optimization of a novel series of GST inhibitors. The authors used affinity mediated DEL selection against a privileged scaffold to identify a compound with potent inhibition against SjGST and GSTM2. SAR studies, coupled with X-ray crystallography and structural analysis, revealed that …Read More >

Resource Type: Latest Science Publication
Resource Topic: Biochemical Assays DNA-Encoded Library (DEL) Hit Finding Hit-to-Lead Lead Optimization Small Molecules Structural Biology

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Translational Pharmacology of CNS and Metabolic Disorders for Testing New Modality Therapies

Animal studies may provide a close approximation to humans when addressing the key challenge of clinical translatability. In the preclinical setting, new insights into disease models and mechanisms are crucial to efficacy studies. In this webinar, Dr. Deming Xu, Chief Pharmacologist, Executive Director, and Head of In Vivo Pharmacology of WuXi AppTec Discovery Biology will …Read More >

Resource Type: Webinar
Resource Topic: Cardiovascular & Metabolic Diseases Central Nervous System & Pain in vivo Pharmacology Metabolic Diseases NASH Oligonucleotides

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Resource Topics
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