Knowledge Library

Hepatobiliary Disease Platform

Hepatobiliary Disease Platform All-encompassing hepatobiliary disease models: NAFLD, NASH, Fibrosis, Cirrhosis, PBC/PSC, ALD, and more Comprehensive hepatic tissue bank and transcriptomics database Professional quantitative analysis in pathology Histopathology Laboratory CAP-certified pathology laboratory Tissue processor Embedding center Cyostats Microtomes Staining workstation IHC & ISH stainer Laser-scanning confocal microscope HALO-AI quantitative histopathology

Resource Type: Brochure
Resource Topic: in vivo Pharmacology Liver Diseases NASH

VIEW

Expanded Role of PDX Models in Anticancer Drug Development

Expanded Role of PDX Models in Anticancer Drug Development Patient-derived xenograft (PDX) models are established by implanting surgically resected patient tumor tissues into immunodeficient mice and have become a pivotal tool in preclinical cancer research due to high clinical-relevance. These models faithfully preserve the original tumor’s molecular, histopathological and pharmacological characteristics, reflecting the heterogeneity and …Read More >

Resource Type: Article Blog
Resource Topic: Oncology Tumor Models

VIEW

Comprehensive Evaluation of Gout Models

Gout is a common type of inflammatory arthritis linked to abnormal uric acid metabolism, resulting in the accumulation of urate crystal deposits in joints. To support the development of effective gout therapies, precise animal models are needed to properly evaluate drug candidates. At IMMUNOLOGY2024, WuXi AppTec presented a poster highlighting the development of multiple preclinical …Read More >

Resource Type: Latest Science Poster
Resource Topic: Autoimmune and Inflammatory Diseases in vivo Pharmacology

VIEW

Preclinical Evaluation of JAK Inhibitors in an Atopic Dermatitis Model

Atopic dermatitis (AD) is a chronic, pruritic inflammatory skin condition that is characterized by recurrent eczematous lesions. Janus kinase (JAK) inhibitors have been found to be efficacious in treating AD, although their mechanism of action in AD is not fully understood. To support preclinical research in this area, WuXi AppTec presented a poster at IMMUNOLOGY2024 …Read More >

Resource Type: Latest Science Poster
Resource Topic: Autoimmune and Inflammatory Diseases in vivo Pharmacology

VIEW

Rapamycin Ameliorates Renal Pathology in a Model of Passive Heymann Nephritis

Passive Heymann nephritis, induced by intravenous injection of anti-Fx1A in susceptible rat strains, is a complement-dependent model of glomerular disease that resembles membranous nephropathy in humans.  At IMMUNOLOGY2024, WuXi AppTec presented a poster demonstrating that rapamycin exerts a protective effect against anti-Fx1A-induced passive Heymann nephritis by reducing proteinuria.  The authors show that this antiproteinuric effect …Read More >

Resource Type: Latest Science Poster
Resource Topic: Immunology in vivo Pharmacology

VIEW

Unveiling Mechanisms of CDK4-CDK6 Inhibitor Resistance in Breast Cancer Models

Cyclin-dependent kinases (CDKs) and their cyclin regulatory subunits form complexes that are essential for driving abnormal growth processes in cancer cells.  Although CDK4/6 inhibitors have shown promising results in the clinic, acquired resistance to these therapies is frequently observed. The successful development of next generation therapeutics necessitates a better understanding of the mechanisms underlying this …Read More >

Resource Type: Latest Science Poster
Resource Topic: Oncology Tumor Models

VIEW

Targeted Protein Degradation of Mutant ER-alpha

Estrogen receptor α (ERα) is considered the main driver in more than 70% of all breast cancers, making this transcription factor an important drug target.  Activating point mutations in the ERα gene, especially Y537S and D538G, have been linked to acquired resistance to endocrine therapies, and there is an urgent need to develop new strategies …Read More >

Resource Type: Latest Science Presentation
Resource Topic: Oncology Targeted Protein Degradation Tumor Models

VIEW

siRNA Efficacy in a Xenograft Tumor Model

Protein kinase N3 (PKN3) is a serine/threonine kinase implicated in tumor progression across multiple cancer types.  PKN3 mRNA is almost undetectable in normal adult tissues but is upregulated in various cancer cells, indicating that siRNA may be a promising approach to inhibit tumor growth by reducing the expression of PKN3.  WuXi AppTec scientists established different siPKN3 molecules and evaluated …Read More >

Resource Type: Latest Science Presentation
Resource Topic: Oligonucleotides Oncology Tumor Models

VIEW

Paclitaxel-Resistant Tumor Models

Despite the excellent clinical response to paclitaxel therapy, drug resistance inevitably develops in subsequent treatments. The mechanisms for resistance to paclitaxel include drug efflux transporter overexpression, altered apoptotic gene expression, and changes associated with microtubules to reduce the influence of this chemotherapeutic agent. The development of targeted therapies for overcoming paclitaxel resistance represents an unmet medical …Read More >

Resource Type: Latest Science Presentation
Resource Topic: Oncology Tumor Models

VIEW


Resource Topics
× peptide, amino acid

Contact An Expert Today!