Knowledge Library
Enabling Technology for Targeted Protein Degradation
Summary Traditional small molecule therapeutic mechanisms have recently been augmented by a new strategy to specifically manipulate the levels of disease-related proteins. By employing bifunctional molecules, we can hijack endogenous cellular degradation mechanism for targeted degradation of a disease-related protein. Bifunctional molecules consisting of a ligand that binds to an E3 ligase, connected by a …Read More >
Outsourcing Drug Discovery and Development: Considerations For Emerging Biopharma Companies
Quantum Mechanics for Organic Chemists: An Experimentalist Approach
Magical Power of Quantum Mechanics EBook Would you like to predict organic reaction outcomes accurately? Design synthetic sequences with higher rate of success? Would you prefer to learn and rationalize organic chemistry in a data-driven manner? Quantum Mechanics (QM) and artificial intelligence tools for chemistry are evolving at a tremendously fast pace and have proven to …Read More >
Targeted Protein Degradation Platform
Integrated Services BIOLOGY & PHARMACOLOGY BINARY/TERNARY COMPLEX FORMATION Biochemical & Biophysical Assays Biochemical binding assay Cellular Assays TARGET UBIQUITINATION & DEGRADATION In vitro Assays-Target ubiquitination Target degradation assay PK/PD Animal Disease Model Evaluation CHEMISTRY Specific virtual library design Compound synthesis Conjugation and all type of custom syntheses from milligram to kilogram scale Purification and analytical …Read More >
One-stop DEL services from target to hit series – DELpro
WuXi AppTec provides a one-stop solution for DEL services from target to hit series. Our extended platform enables overall planning and management of protein production, DEL library production, affinity selection, data analysis, hit validation and structural biology for further optimization.
Open Access to DEL for data sharing – DELopen
DELopen platform is dedicated to the development and application of DEL technology in drug discovery. Free access to DEL, data sharing. DELopen encourages an open, community-based approach to data sharing and exploration of the capabilities of DEL technology. We envision that DELopen will help academia benefits from the efficiency of DEL and unlock the full …Read More >
DNA-encoded libraries for academic – DELopen Handbook
DNA-encoded libraries for academic | Open Access to DEL Self-service platform for academia to utilize the full potential of DEL technology DELopen provides free access to DNA-encoded libraries (DEL) for academic users and encourages an open, community-based approach to data sharing.
Discovery Chemistry Outsourcing Services
Global Leader in Discovery Chemistry Outsourcing Services Based on FTE (Full Time Equivalent) Model | Customization to Client’s Synthetic Chemistry with high productivity, quality, speed, and reliability Project Management: we manage project timelines and compound flow Medicinal Chemistry: we provide compound design and project management Integrated Projects from targets to hits to leads to preclinical …Read More >
