Knowledge Library

High-Dimensional Flow Cytometry Platform

High-dimensional (HD) flow cytometry allows researchers to perform deep phenotyping of immune cells at the single cell level with increased accuracy and sensitivity.  This technology enables complex pathway characterization and data integration for the identification of biomarkers used in immunotherapy.  WuXi AppTec offers a comprehensive panel of HD flow cytometry services, with more than 100 …Read More >

Resource Type: Latest Science Presentation
Resource Topic: Autoimmune and Inflammatory Diseases Biomarkers Oncology Phenotypic Assays

VIEW

STX-478, a Mutant-Selective, Allosteric PI3Kα Inhibitor Spares Metabolic Dysfunction and Improves Therapeutic Response in PI3Kα-Mutant Xenografts

The contribution of the X-ray crystallography team from our WuXi AppTec site in Germany was acknowledged in a recent study published in the journal Cancer Discovery. In this study, the authors show that compound STX-478, an allosteric PI3Kα inhibitor, selectively targets prevalent PI3Kα helical- and kinase-domain mutant tumors. STX-478 demonstrated robust efficacy in human tumor …Read More >

Resource Type: Latest Science Publication
Resource Topic: Oncology Small Molecules Structural Biology Structural Biology X-ray Crystallography

VIEW

Immune-Avatar Humanized Tumor Models

To support antitumor efficacy testing and address the challenges of clinical translatability, WuXi AppTec offers extensive panels of immune-avatar humanized mouse models. Our platform includes hPBMC, hHSC, and hNK humanized models with enabling studies from our platform of over 1,700 CDX and PDX models. These well-established models cover multiple cancer types, including breast, lung, liver, …Read More >

Resource Type: Latest Science Presentation
Resource Topic: Oncology Tumor Models

VIEW

Expanded Applications of PDX Models

Patient-derived xenografts (PDXs) represent a powerful platform for cancer drug screening and biomarker discovery and are considered the gold standard of in vivo models for their proven clinical relevance to human disease. WuXi AppTec offers a comprehensive platform of more than 1,400 well-annotated PDXs across 30 cancer types. We also provide expanded in vitro, ex …Read More >

Resource Type: Latest Science Presentation
Resource Topic: Cell-based Assays Oncology Tumor Models

VIEW

Emerging Drug Discovery Strategies for Targeted Protein Degradation

In the last decade, targeted protein degradation (TPD) technology has become one of the most promising methods to remove specific disease-related proteins using cellular self-destruction mechanisms.  In our latest White Paper, “Emerging Drug Discovery Strategies for Targeted Protein Degradation” we explore how DNA-encoded library (DEL) technology can be used for direct discovery of proteolysis-targeting chimeras …Read More >

Resource Type: Latest Science White Paper
Resource Topic: Discovery Chemistry DNA-Encoded Library (DEL) Targeted Protein Degradation

VIEW

TAAR1 as an Emerging Target for the Treatment of Psychiatric Disorders

A growing body of in vitro and in vivo evidence has demonstrated that trace amine-associated receptor 1 (TAAR1) could negatively modulate monoamine transmission and play a crucial role in many psychiatric disorders, including schizophrenia, depression, and anxiety. WuXi AppTec contributed to a review article in the journal Pharmacology & Therapeutics, discussing the current understanding of …Read More >

Resource Type: Latest Science Publication
Resource Topic: Central Nervous System & Pain

VIEW

Preclinical platform for nucleic acid drug evaluation: siRNA and mRNA therapeutics

SITC Poster #59: Since the emergence of the COVID-19 pandemic, numerous nucleic-acid therapeutics have been approved for clinical use. Distinguished from conventional protein-targeted therapy, nucleic acid therapeutics offer the potential for sustained effects via gene modification or inhibition. In this study, we conducted a comprehensive evaluation of the activity and anti-tumor effects of PKN3-targeted siRNA …Read More >

Resource Type: Latest Science Poster
Resource Topic: Antibodies Cell-based Assays Oligonucleotides Oncology Tumor Models

VIEW

Baricitinib treatment reduces the expansion of CD8+ T cells in C3H mice with skin grafts-induced alopecia areata

SITC Poster #452: Alopecia areata (AA) is an autoimmune disease characterized by patchy and sudden hair loss without scarring, resulting in a heavy psychological burden on patients. To better understand the pathogenesis and treatment of alopecia areata, we developed a skin grafts-induced alopecia areata model to provide a reproducible, reliable animal model for AA research. …Read More >

Resource Type: Latest Science Poster
Resource Topic: Autoimmune and Inflammatory Diseases in vivo Pharmacology

VIEW

Administration of JAK and TYK2 inhibitors successfully ameliorate the severity of T cell transfer-induced colitis in mice

SITC Poster #446: Inflammatory bowel disease (IBD) is recognized as an autoimmune disorder characterized by chronic inflammation of the digestive tract. The pathogenesis of IBD is not fully understood and can repeatedly relapse despite clinical therapy. The T cell transfer-induced colitis model enables the study of early inflammation and immunological responses in the colon, such …Read More >

Resource Type: Latest Science Poster
Resource Topic: Autoimmune and Inflammatory Diseases in vivo Pharmacology

VIEW


Resource Topics
× peptide, amino acid

Contact An Expert Today!