Knowledge Library

WuXi AppTec in vitro Neuroscience Services

Neurological disorders, such as neurodegenerative diseases, epilepsy, chronic pain, psychiatric disorders, are one of today’s largest unmet medical needs. However, due to poor disease and target understanding, Neuroscience drug discovery can be very challenging. An open access research platform with dedicated neuroscience specialists and integrated services will be an ideal partner throughout your drug discovery …Read More >
Resource Type: Brochure
Resource Topic: Antibodies Biochemical Assays Biomarkers Cell-based Assays Cells and Protein Science Central Nervous System & Pain Hit Finding Hit-to-Lead in vitro biology Lead Optimization Phenotypic Assays Rare Diseases Safety and Early Toxicity Small Molecules Target Identification and Validation

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WuXi AppTec Oligonucleotide Biology Platform

WuXi Biology oligonucleotide capabilities Sequence design Knockdown effect incell lines and primary cells (transfection d f uptake) Splicing analysis Functional assays Other assays: Tm determination Cytotoxicity lmmunotoxicity Off-target effect “Humanized” mouse models Transgenic, HDI and AAV mouse models NHP models Short and longterm KD efficacy/ harmacology readouts GalNAc-ASGPR delivery system SPR screening Customized assays for …Read More >
Resource Type: Brochure
Resource Topic: Biochemical Assays Candidate Selection Cell-based Assays Discovery Chemistry Gene Manipulation Gene Therapies Hit-to-Lead in vivo Pharmacology Lead Optimization Liver Diseases Oligonucleotides Rare Diseases Safety and Early Toxicity Target-Specific Assays

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Oligonucleotide Drug Discovery

Recent years have seen a huge surge of interest in oligonucleotide therapeutics, fueled by major advances in our understanding of how to make such molecules stable, selective, and efficient as drug modalities. The field is now diverse in terms of therapeutic areas being addressed, biological processes being manipulated and delivery technologies employed. In this webinar, …Read More >
Resource Type: Webinar
Resource Topic: Biochemical Assays Cell-based Assays Discovery Chemistry Hit-to-Lead in vitro biology in vivo Pharmacology Lead Optimization Oligonucleotides Safety and Early Toxicity

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Pain Discovery Assays & in vivo Studies

WuXi Discovery Services supports all of your research needs, including target discovery, in vitro and in vivo pharmacology, translational research and clinical biomarker testing, to enable drug discovery for your target compound for pain. Full-scale molecular characterizations from gene/protein expression in vitro functional assays with validation of GPCR, Kinase and ion channel targets Selectivity profiling …Read More >
Resource Type: Brochure
Resource Topic: Biochemical Assays Biomarkers Cell-based Assays Central Nervous System & Pain in vitro biology in vivo Pharmacology Lead Optimization Target Identification and Validation Target-Specific Assays

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OncoWuXi Newsletter: June 2022

WuXi AppTec xenograft and syngeneic tumor models in rats and CD47-related in vitro assay platform
Resource Type: Newsletter
Resource Topic: Antibodies Cell-based Assays Hit-to-Lead in vivo Pharmacology Lead Optimization Oncology Target-Specific Assays Tumor Models

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WuXi AppTec Discovery Services

Delivering comprehensive end-to-end solutions for creating, identifying, and supporting preclinical candidates, from discovery to development, with our integrated chemistry and biology research platform. Integrated Chemistry and Biology Research Platform | From Discovery to Candidate Selection and Beyond
Resource Type: Brochure
Resource Topic: Antibodies Antibody Drug Conjugate Autoimmune and Inflammatory Diseases Biochemical Assays Biomarkers Biophysical Assays Candidate Selection CAR-T Cell Cardiovascular & Metabolic Diseases Cell Therapies Cell-based Assays Cells and Protein Science Central Nervous System & Pain Chemical Biology and Proteomics CRISPR/Cas9 Dermatology Discovery Chemistry DNA-Encoded Library (DEL) DRUG DISCOVERY AND INNOVATION Fragment-Based Drug Discovery Gene Manipulation Gene Therapies High-throughput screening (HTS) Hit Finding Hit-to-Lead Immunology in silico services in vitro biology in vivo Pharmacology in vivo Toxicology Infectious Diseases Lead Optimization Liver Diseases Mass Spectrometry-based Assays Metabolic Diseases NASH Oligonucleotides Oncology Oncolytic Viruses Ophthalmology Phenotypic Assays Quantum Mechanics Rare Diseases Respiratory Diseases Safety and Early Toxicity Screening Libraries Screening Services Small Molecules Structural Biology Target Identification and Validation Target-Specific Assays Targeted Protein Degradation TECHNOLOGY PLATFORMS THERAPEUTIC AREAS THERAPEUTIC MODALITIES Tumor Models

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Bone metastasis platform to evaluate prophylaxis and treatment
Resource Type: Presentation
Resource Topic: in vivo Pharmacology Lead Optimization Oncology Small Molecules Target Identification and Validation

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Structure-based optimization of hydroxylactam as potent, cell-active inhibitors of lactate dehydrogenase

Structure-based design was utilized to optimize 6,6-diaryl substituted dihydropyrone and hydroxylactam to obtain inhibitors of lactate dehydrogenase (LDH) with low nanomolar biochemical and single-digit micromolar cellular potencies. Surprisingly the replacement of a phenyl with a pyridyl moiety in the chemical structure revealed a new binding mode for the inhibitors with subtle conformational change of the …Read More >
Resource Type: Publication
Resource Topic: Chemical Biology and Proteomics Discovery Chemistry Hit-to-Lead Lead Optimization Oncology Small Molecules

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Brain metastasis mouse models for the evaluation of multikinase inhibitors on ROS1-fusion-positive lung cancer
Resource Type: Poster
Resource Topic: in vivo Pharmacology Lead Optimization Oncology Small Molecules Tumor Models

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