Knowledge Library

Drugging the Undruggable: Leveraging the Right Screening Methods for Challenging Targets

Challenging targets, such as membrane proteins or protein-protein interactions were considered undruggable in the past. However, today a variety of screening methods can be used to help develop drugs against these formerly undruggable targets.

Resource Type: Infographic
Resource Topic: DNA-Encoded Library (DEL) Hit Finding in silico services Mass Spectrometry-based Assays Screening Services Small Molecules Structural Biology Target Identification and Validation Targeted Protein Degradation

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WuXi AppTec Discovery Services

Delivering comprehensive end-to-end solutions for creating, identifying, and supporting preclinical candidates, from discovery to development, with our integrated chemistry and biology research platform. Integrated Chemistry and Biology Research Platform | From Discovery to Candidate Selection and Beyond

Resource Type: Brochure
Resource Topic: Antibodies Antibody Drug Conjugate Autoimmune and Inflammatory Diseases Biochemical Assays Biomarkers Biophysical Assays Candidate Selection CAR-T Cell Cardiovascular & Metabolic Diseases Cell Therapies Cell-based Assays Cells and Protein Science Central Nervous System & Pain Chemical Biology and Proteomics CRISPR/Cas9 Dermatology Discovery Chemistry DNA-Encoded Library (DEL) DRUG DISCOVERY AND INNOVATION Fragment-Based Drug Discovery Gene Manipulation Gene Therapies High-throughput screening (HTS) Hit Finding Hit-to-Lead Immunology in silico services in vitro biology in vivo Pharmacology in vivo Toxicology Infectious Diseases Lead Optimization Liver Diseases Mass Spectrometry-based Assays Metabolic Diseases NASH Oligonucleotides Oncology Oncolytic Viruses Ophthalmology Phenotypic Assays Quantum Mechanics Rare Diseases Respiratory Diseases Safety and Early Toxicity Screening Libraries Screening Services Small Molecules Structural Biology Target Identification and Validation Target-Specific Assays Targeted Protein Degradation TECHNOLOGY PLATFORMS THERAPEUTIC AREAS THERAPEUTIC MODALITIES Tumor Models

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Integrating Practical Machine Learning and Quantum Mechanics Tools to Synthesis in Medicinal Chemistry

Resource Type: Presentation Video
Resource Topic: Chemical Biology and Proteomics Discovery Chemistry in silico services Quantum Mechanics Small Molecules

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Meeting Neurodegenerative Disease Head-On with Emerging Drug Discovery Strategies

Chronic neurodegenerative diseases encompass a variety of progressive conditions that affect neurons, including Huntington’s disease, Parkinson’s disease, Alzheimer’s disease, and other forms of dementia. They are among the most common and challenging central nervous system (CNS) diseases. “Many companies had stopped their research program into neurodegenerative diseases, but now sophisticated technology advances have became more broadly …Read More >

Resource Type: White Paper
Resource Topic: Biomarkers Cell-based Assays Central Nervous System & Pain Chemical Biology and Proteomics Hit-to-Lead in silico services in vivo Pharmacology Lead Optimization Rare Diseases

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WuXi Discovery Services Newsletter: April 2021

Resource Type: Newsletter
Resource Topic: Discovery Chemistry in silico services Quantum Mechanics

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How to Accelerate the Rate Limiting Step in Drug Discovery, Synthesis of Target Molecules

Resource Type: Webinar
Resource Topic: Chemical Biology and Proteomics Discovery Chemistry in silico services Quantum Mechanics Small Molecules

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Enabling Drug Discovery with Diverse Lead Generation Platforms

Resource Type: Webinar
Resource Topic: Discovery Chemistry DNA-Encoded Library (DEL) Fragment-Based Drug Discovery High-throughput screening (HTS) Hit Finding Hit-to-Lead in silico services Lead Optimization Mass Spectrometry-based Assays Screening Libraries Screening Services Small Molecules Structural Biology Target Identification and Validation

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Novel Strategies to Accelerate Discovery of Translatable Therapeutic Targets

Resource Type: Webinar
Resource Topic: Biomarkers Hit Finding Hit-to-Lead in silico services Liver Diseases Oncology Target Identification and Validation

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Empowering Organic Syntheses with Quantum Mechanics Analyses

Syntheses of specifically functionalized molecules continue to be rate limiting steps (RLS) in drug discovery. Improvement in this RLS means investing only in reactions/synthetic sequences that are more likely to succeed. Structural diversifications, different substitution patterns or unique heterocyclic systems can often adversely impact the crucial step(s) of established synthetic sequences or development of feasible …Read More >

Resource Type: Article
Resource Topic: Chemical Biology and Proteomics Discovery Chemistry Hit-to-Lead in silico services Lead Optimization Quantum Mechanics Small Molecules

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