Knowledge Library

Novel Strategies to Accelerate Discovery of Translatable Therapeutic Targets

Resource Type: Webinar
Resource Topic: Biomarkers Hit Finding Hit-to-Lead in silico services Liver Diseases Oncology Target Identification and Validation

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Drug Hunter: Discovering New Frontiers in Cancer Treatments & Beyond

INNOVATION THAT MATTERS By Rich Soll, Senior Advisor, Strategic Initiatives at WuXi AppTec (@richsollwx) As a self-proclaimed drug hunter, Phil Jones is on a mission to identify the next generation of cancer medicines that improve the lives of patients with cancer. He leads a multi-disciplinary team of scientists at The University of Texas MD Anderson Cancer Center’s Institute …Read More >

Resource Type: Article
Resource Topic: Biomarkers CAR-T Cell Cells and Protein Science Chemical Biology and Proteomics DRUG DISCOVERY AND INNOVATION Hit Finding in vitro biology in vivo Pharmacology Oncology Phenotypic Assays Small Molecules Target Identification and Validation

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Faster with high-speed fragment screening — Accelerate your drug discovery campaign

In the past, thousands of proteins were considered undruggable. The restricted number of chemical entities available and classical methods limited the exploration of this undevelopable area. Today, the combination of novel chemical modalities and advanced technical approaches has resulted in new clinical candidates from previously undruggable targets. To accelerate your drug discovery campaign, WuXi AppTec´s …Read More >

Resource Type: Article Blog Case Study
Resource Topic: Biochemical Assays Biophysical Assays Fragment-Based Drug Discovery Hit Finding Hit-to-Lead Immunology Lead Optimization Small Molecules Structural Biology

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Unlocking the potential of DEL | Inspire Hit Discovery

March 4, 2020 – By going commercial, DNA Encoded Library (DEL) technology facilitates rapid discovery and provides access to more chemical entities at lower cost. Over the years, DEL has become a disruptive drug discovery technology in comparison to traditional high-throughput screening (HTS) where it allows expedition of early stage drug discovery. However, DEL platforms don’t succeed …Read More >

Resource Type: Article
Resource Topic: Biophysical Assays DNA-Encoded Library (DEL) Hit Finding Small Molecules Target Identification and Validation

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Bifunctional Molecules: A Diverse New Modality That Unlocks New Target Classes

Resource Type: White Paper
Resource Topic: Hit Finding Hit-to-Lead Oncology Small Molecules Target-Specific Assays Targeted Protein Degradation

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Outsourcing Drug Discovery and Development: Considerations For Emerging Biopharma Companies

Resource Type: White Paper
Resource Topic: Candidate Selection Discovery Chemistry DRUG DISCOVERY AND INNOVATION Hit Finding Hit-to-Lead Lead Optimization Target Identification and Validation

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One-stop DEL services from target to hit series – DELpro

WuXi AppTec  provides a one-stop solution for DEL services from target to hit series. Our extended platform enables overall planning and management of protein production, DEL library production, affinity selection, data analysis, hit validation and structural biology for further optimization.

Resource Type: Brochure
Resource Topic: Biophysical Assays Cells and Protein Science Discovery Chemistry DNA-Encoded Library (DEL) Hit Finding Hit-to-Lead Small Molecules Target Identification and Validation

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Open Access to DEL for data sharing – DELopen

DELopen platform is dedicated to the development and application of DEL technology in drug discovery. Free access to DEL, data sharing. DELopen encourages an open, community-based approach to data sharing and exploration of the capabilities of DEL technology. We envision that DELopen will help academia benefits from the efficiency of DEL and unlock the full …Read More >

Resource Type: Brochure
Resource Topic: Discovery Chemistry DNA-Encoded Library (DEL) Hit Finding Screening Libraries Small Molecules Target Identification and Validation

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DNA-encoded libraries for academic – DELopen Handbook

DNA-encoded libraries for academic | Open Access to DEL Self-service platform for academia to utilize the full potential of DEL technology DELopen provides free access to DNA-encoded libraries (DEL) for academic users and encourages an open, community-based approach to data sharing.

Resource Type: Brochure
Resource Topic: Discovery Chemistry DNA-Encoded Library (DEL) Hit Finding Screening Libraries Small Molecules Target Identification and Validation

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