Knowledge Library

DNA-Encoded Macrocyclic Peptide Libraries Enable the Discovery of a Neutral MDM2–p53 Inhibitor

Macrocyclic peptides are an emerging molecular class for targeting intracellular protein–protein interactions (PPIs) and for providing an oral modality for drug targets. Herein, we use DNA-encoded cyclic peptide libraries to discover a neutral nonapeptide, UNP-6457, that inhibits MDM2–p53 interaction with an IC50 of 8.9 nM. These studies showcase how tailored DEL libraries can directly yield …Read More >

Resource Type: Latest Science Publication
Resource Topic: Biochemical Assays DNA-Encoded Library (DEL) Hit Finding Hit-to-Lead Lead Optimization Oncology Structural Biology

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Discovery of RNA Targeting Small Molecules – Our Toolbox for RNA Drug Discovery

Drug Discovery Chemistry Conference 2023 WuXi AppTec has developed technologies to facilitate RNA small molecule screening, an exciting frontier in drug discovery. SHAPE-MaP is applied to determine RNA structure and dynamics and verify small molecule binding. We utilize the “DNA-Zipper” strategy to enable DNA-encoded libraries to identify RNA binders. With other technologies including fragment-based drug …Read More >

Resource Type: Presentation Video
Resource Topic: Biophysical Assays DNA-Encoded Library (DEL) Fragment-Based Drug Discovery Hit Finding Hit-to-Lead Mass Spectrometry-based Assays Oligonucleotides Small Molecules

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DNA-Encoded Libraries for the Discovery of Small-Molecule Hits

Drug Discovery Chemistry Conference 2023 DNA-Encoded library (DEL) screening is now commonly used in the pharmaceutical industry to find novel chemical matter that modulates protein targets of interest.  Point-by-point, Dr. Alex Satz, Executive Director, WuXi Biology will discuss the primary challenges and limitations of DEL screening, and concisely state the current abilities of the technology …Read More >

Resource Type: Presentation Video
Resource Topic: DNA-Encoded Library (DEL) Hit Finding in silico services Screening Services Small Molecules

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DNA-Encoded Libraries: DELight Handbook

Resource Type: Brochure
Resource Topic: DNA-Encoded Library (DEL) Hit Finding Screening Services Small Molecules

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DNA-Encoded Libraries: DELight User Manual

Resource Type: Brochure
Resource Topic: DNA-Encoded Library (DEL) Hit Finding Screening Services Small Molecules

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DNA-Encoded Libraries: DELight Flyer

Resource Type: Brochure Latest Science
Resource Topic: DNA-Encoded Library (DEL) Hit Finding Screening Services Small Molecules

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Case Study: DEL Data Combined with In Silico Deep-Learning Model

Read our newest case study on enhancing predictivity of drug-target interactions. In collaboration with Cyclica, WuXi AppTec scientists engaged in a study to understand the synergies between DNA encoded library (DEL) screening and Cyclica’s MatchMaker™ deep-learning model for protein-ligand interactions. Our findings indicate that combining experimental DEL data with computational analysis from MatchMaker™ can lead …Read More >

Resource Type: Case Study Latest Science
Resource Topic: DNA-Encoded Library (DEL) Hit Finding in silico services

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DNA-Encoded Libraries: DELopen Handbook

Resource Type: Brochure
Resource Topic: DNA-Encoded Library (DEL) Hit Finding Screening Services Small Molecules

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DNA-Encoded Libraries: DELopen User Manual

Resource Type: Brochure
Resource Topic: DNA-Encoded Library (DEL) Hit Finding Screening Services Small Molecules

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