BMCS Conformational Design in Drug Discovery 2024
Conformational Design has played a key role in the medicinal chemistry of small molecule clinical candidates over the last 20 years. A key learning from multiple projects supported by experimental free ligand NMR solution conformations and protein-ligand X-ray structures is that the bioactive conformation of potent ligands is highly populated in solution. Ligand rigidification has been particularly successful in the design of selective and potent protein-protein interaction inhibitors and is becoming an increasingly important approach for PROTACs, molecular glues and other new modalities. Join us at this new RSC-BMCS event which aims at building a community that shares conformational design strategies, technologies, and successful case studies.
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WuXi AppTec Discovery Services
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Research Chemistry Services
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BMCS Conformational Design in Drug Discovery 2024
Resource Type: Brochure
