CRISPR/Cas9 technology

• Stable or inducible cell line generation (KO,KI, OEX, KD)
• sgRNA library screen (sgRNAi, sgRNAa)
• Allele-specific genome editing
• Genetically engineered mouse models
• Primary cells, iPSC gene manipulation
• Base-editing

CRISPR screening platform

• In-house pipeline for customized design
• Cancer cell line based positive selection or negative selection screen to identify mechanism of drug resistance or essential genes
• CRISPR screen in cancer cell and T cell co-culture to identify regulators of cancer cell response to T cell cytotoxicity
• Bioinformatics workflow for screening data
• In vivo CRISPR screen for cancer immunotherapy modulators in syngeneic tumor models

AAV platform

• Large collection of AAV vectors
• Established delivery routes for AAV
serotypes
• Providing clients with AAV
technology for target gene OEX, KD in all therapeutic areas

shRNA

• Inducible KD and OEX