Comprehensive platform for Target Identification and Validation

WuXi Biology integrated Advanced Gene Manipulation (AGM™) platform offers innovative technologies and know-how with comprehensive options from cellular, tissue, and in vivo studies.

CRISPR/Cas9 technology

  • Stable or inducible cell line generation (KO,KI, OEX, KD)
  • sgRNA library screen (sgRNAi, sgRNAa)
  • Allele-specific genome editing
  • Genetically engineered mouse models
  • Primary cells, iPSC gene manipulation
  • Base-editing

CRISPR screening platform

  • In-house pipeline for customized design
  • Cancer cell line based positive selection or negative selection screen to identify mechanism of drug resistance or essential genes
  • CRISPR screen in cancer cell and T cell co-culture to identify regulators of cancer cell response to T cell cytotoxicity
  • Bioinformatics workflow for screening data
  • In vivo CRISPR screen for cancer immunotherapy modulators in syngeneic tumor models

AAV platform

• Large collection of AAV vectors
• Established delivery routes for AAV
serotypes
• Providing diverse clients with AAV
technology for target gene OEX, KD in all therapeutic areas

shRNA

• Inducible KD and OEX