Knowledge Library

OncoWuXi Express: Efficacy of DLL3 CAR-T in SHP-77 Tumor Models

OncoWuXi Express: Evaluation of DLL3 CAR-T in SHP-77-Luc Tumor Models  Introduction: OncoWuXi Express will continue to keep you informed about updates to our online tumor model database (OncoWuXi Database), as well as our recent progress in cancer and autoimmune research. In this issue, we showcase our DLL3 CAR-T cell preparation and evaluation of their anti-tumor …Read More >

Resource Type: Article, Blog
Resource Topic: CAR-T Cell, Oncology, Tumor Models

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Creating a Biological Switch Using DEL Technology

In addition to identifying chemical starting points for early drug discovery processes, DNA-encoded library (DEL) technology has now expanded to new applications, including the discovery of bifunctional affinity ligands historically considered difficult to develop. At the 2024 Gordon Research Conference, WuXi AppTec presented a poster describing how DEL can enable the rapid discovery of novel …Read More >

Resource Type: Latest Science, Poster
Resource Topic: Biochemical Assays, CAR-T Cell, Cell-based Assays, DNA-Encoded Library (DEL), Hit Finding

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Recent Insights into Immuno-Oncology

The efficacy of CAR-T therapy is substantially influenced by the tumor microenvironment. This is particularly evident when PD-L1 is activated through CAR-T, leading to the inhibition of CAR-T cell activity via the PD-1 pathway. At the 2024 Recent Insights into Immuno-Oncology Conference, WuXi AppTec presented a poster describing an engineered CAR-T therapy that targets mesothelin …Read More >

Resource Type: Latest Science, Poster
Resource Topic: CAR-T Cell, Oncology

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Integrated Platform of siRNA Drug Discovery

RNA interference using small interfering RNA (siRNA) molecules has emerged as a promising therapeutic modality.  To accelerate the discovery of novel siRNAs, WuXi AppTec has established an integrated platform encompassing siRNA sequence design, chemical synthesis/modification, delivery ligand exploration, and activity/off-target assessment. At the TIDES USA 2024 Conference, our scientists presented a poster showcasing the effectiveness …Read More >

Resource Type: Latest Science, Poster
Resource Topic: Autoimmune and Inflammatory Diseases, Oligonucleotides

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DEL Empowers Discovery of Peptide Drugs

Despite the resurgence of interest in peptide therapeutics for historically “undruggable” targets, de novo discovery of peptide ligands remains a challenge.  Unlike traditional technologies, DNA-encoded libraries (DELs) predominantly employ unnatural amino acids, and the resulting cyclic peptide-like molecules which are generated display a wider range of chemical space and smaller ring sizes with improved physicochemical …Read More >

Resource Type: Latest Science, Poster
Resource Topic: DNA-Encoded Library (DEL), Peptides

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Integrated Screening in Hit Identification

Despite the availability of modern screening technologies, identification and optimization of hits against poorly druggable targets remains a significant challenge for drug discovery teams.  Generating hit matter and reference compounds with one screening technology and then screening with a second technology has the potential to be a powerful tool for researchers. At this year’s Oxford …Read More >

Resource Type: Latest Science, Poster
Resource Topic: DNA-Encoded Library (DEL), Hit Finding, Hit-to-Lead, Small Molecules

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Oligonucleotide Services

Choose excellence, choose WuXi Biology- your reliable partner in oligonucleotide drug discovery. WuXi Biology provides an integrated service platform for support of the discovery of oligonucleotide drugs. Our services cover sequence and modification design of oligonucleotides, in vitro and in vivo biological and PK/PD evaluations, and assessment of oligonucleotide off-target effects. Our broad and deep …Read More >

Resource Type: Brochure
Resource Topic: Oligonucleotides

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mRNA Services Platform

Design and production of mRNA Design and optimization of mRNA sequences Utilizing the design and optimization techniques for mRNA sequences, UTR screening, and codon optimization Plasmid and DNA template productions for in vitro transcription Employment of a classical three-step purification method Implementation of mono-enzyme digestion and purification through chromatography Research scale mRNA production and characterization …Read More >

Resource Type: Brochure
Resource Topic: Oligonucleotides

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Targeted Protein Degradation of Mutant ER-alpha

Estrogen receptor α (ERα) is considered the main driver in more than 70% of all breast cancers, making this transcription factor an important drug target.  Activating point mutations in the ERα gene, especially Y537S and D538G, have been linked to acquired resistance to endocrine therapies, and there is an urgent need to develop new strategies …Read More >

Resource Type: Latest Science, Presentation
Resource Topic: Oncology, Targeted Protein Degradation, Tumor Models

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Resource Topics
× peptide, amino acid

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