Knowledge Library

Asthma Services Platform

Asthma is a chronic, lower airway disease characterized by persistent inflammation and hyperreactivity. Asthma involves a complex immune response, with T-helper 2 (Th2) cells playing a central role, leading to activation of eosinophils and increased levels of IgE antibodies. Clinically, airflow obstruction in asthma often is not fully reversible, and many asthmatic subjects experience an …Read More >

Resource Type: Presentation
Resource Topic: Cell-based Assays, in vivo Pharmacology, Respiratory Diseases

VIEW

Pulmonary Disease Platform

WuXi AppTec offers a comprehensive platform of pulmonary disease-related services.  We provide a wide panel of validated disease models, including pulmonary fibrosis, pulmonary arterial hypertension, asthma, and chronic obstructive pulmonary disease. Our experts utilize advanced technologies with fully equipped invasive and non-invasive systems, such as the pulmonary function test system.

Resource Type: Brochure
Resource Topic: in vivo Pharmacology, Respiratory Diseases

VIEW

Integrated Assay Platform Targeting HMPV Infection

Human metapneumovirus (HMPV) is a common cause of respiratory tract infections in young children, older adults, and people with weakened immune systems. HMPV is in the Pneumoviridae family along with the more commonly known respiratory syncytial virus (RSV).  Currently, there is no specific antiviral therapy to treat HMPV and no vaccine to prevent HMPV. At …Read More >

Resource Type: Latest Science, Poster
Resource Topic: Infectious Diseases, Respiratory Diseases

VIEW

Fibrosis Models in Mice and Rats

Selecting preclinical in vivo models that are reflective of clinical outcome is a key challenge in the development of new therapies to treat fibrotic diseases.  To accelerate research focused on pulmonary, renal, and liver fibrosis, WuXi AppTec has established a series of in vivo models supported with anti-fibrotic efficacy data.  Our platform also includes a …Read More >

Resource Type: Presentation
Resource Topic: Autoimmune and Inflammatory Diseases, Liver Diseases, NASH, Respiratory Diseases

VIEW

AACR 2023: Comparison of two DTH models for T cell-mediated immunity

To characterize the immunity profile of the most widely used delayed-type hypersensitivity (DTH) models, WuXi AppTec scientists built 2,4-dinitrofluorobenzene (DNFB) and oxazolone-induced DTH models in both BALB/c and C57BL/6 mice with robust ear thickness as the readout. Check out our comprehensive panel of services related to autoimmune and inflammatory diseases

Resource Type: Latest Science, Poster
Resource Topic: Autoimmune and Inflammatory Diseases, in vivo Pharmacology, Lead Optimization, Respiratory Diseases

VIEW

Large-scale synthesis of a Notum inhibitor employing a modified Sakai reaction as the key step

WuXi AppTec scientists recently contributed to a research article in the Royal Society of Chemistry describing the large-scale synthesis of a potent and selective inhibitor of Notum carboxylesterase (an enzyme that suppresses Wnt signaling pathways).  By employing a modified Sakai reaction as the key step, a one-pot synthesis of this Notum inhibitor was developed, enabling …Read More >

Resource Type: Latest Science, Publication
Resource Topic: Cardiovascular & Metabolic Diseases, Discovery Chemistry, Liver Diseases, Oncology, Respiratory Diseases, Small Molecules

VIEW


Resource Topics
× peptide, amino acid

Contact An Expert Today!