One Stop Target-to-Hit Platform: CRBN-DDB1

Cereblon (CRBN) forms an E3 ligase complex together with DDB1, CUL4, and RBX1. CRBN functions as a substrate receptor of this complex, and this protein is a key target for the action of small molecules.  Targeting of CRBN can modify its substrate specificity towards non-physiological proteins, which are subsequently ubiquitinated and degraded by the proteasome.

To support the discovery of CRBN-DDB1 PROTACs® and molecular glues, WuXi AppTec offers a comprehensive platform of ready-to-go biophysical assays, high-quality protein production, and established X-ray crystallography protocols.

Target of the month_CRBN-DDB1

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