Resources Archive - Page 3 of 7

Dianthus Platform: Screening for Inhibitors of PIK3CA-PIK3R1

Within the PI3K family, the heterodimer comprising the p110-α catalytic and p85-α regulatory subunits (encoded by PIK3CA and PIK3R1) is...

Dianthus Platform: Screening for Inhibitors of PRMT5-WDR77

Protein arginine methyltransferase 5 (PRMT5) is an enzyme which plays an essential role in a wide range of cellular processes. ...

Dianthus Platform: Screening for Modulators of STING

The adaptor protein STING (stimulator of interferon genes) has emerged as an exciting target for both immunological conditions (STING inhibition)...

Screening Methods to Identify RNA-Targeting Small Molecules

RNA molecules are promising drug targets due to their genomic prevalence, disease involvement, and druggable complex structures. Successful examples include...

One Stop Target-to-Hit Platform: PIK3CA–PIK3R1

Within the PI3K family, the heterodimer protein comprising the p110-α and p85-α catalytic/regulatory subunits (encoded by PIK3CA and PIK3R1) are...

One Stop Target-to-Hit Platform: Protein arginine methyltransferase 5 (PRMT5)

Protein arginine methyltransferase 5 (PRMT5) is an enzyme which plays an essential role in a wide range of cellular processes. ...

One Stop Target-to-Hit Platform: Cyclin-dependent kinase 2 (CDK2)

Cyclin-dependent kinase 2 (CDK2) and its respective cyclin E1 and cyclin A2 complexes are essential to driving abnormal growth processes...

One Stop Target-to-Hit Platform: Werner Syndrome Helicase (WRN)

Werner syndrome helicase (WRN) is a key drug target for cancers with microsatellite instability. To support the discovery of potent...

Regenerable Surface Plasmon Resonance (SPR) Surfaces for Reliable, Cost-Effective, and Wide-Ranging Applications

Traditional SPR-based drug discovery efforts in the small-molecule space have revolved around single-use chips for screening and hit-to-lead efforts. Inspired...

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