Choose excellence, choose WuXi Biology- your reliable partner in oligonucleotide drug discovery. WuXi Biology provides an integrated service platform for support of the discovery of oligonucleotide drugs. Our services cover sequence and modification design of oligonucleotides, in vitro and in vivo biological and PK/PD evaluations, and assessment of oligonucleotide off-target effects. Our broad and deep …Read More >

Design and production of mRNA Design and optimization of mRNA sequences Utilizing the design and optimization techniques for mRNA sequences, UTR screening, and codon optimization Plasmid and DNA template productions for in vitro transcription Employment of a classical three-step purification method Implementation of mono-enzyme digestion and purification through chromatography Research scale mRNA production and characterization …Read More >

Capacity Comprehensive virus, bacteria, fungi coverages Supporting drug and vaccine discovery from early research to clinical trials Capability 20+ various viruses Supporting discovery of antivirals and vaccines, including HBV, SARS-CoV, IFV, RSV, HCV, HIV, EV71, herpes, rabies, and other viruses 130+ different bacterial and fungal species Supporting discovery of antibacterial and antifungal therapeutics, including ESKAPE, …Read More >

The hepatobiliary system (comprised of the liver, gallbladder, and bile ducts) plays an important role in digestion and in the biotransformation and disposition of endogenous molecules and drugs. Hepatobiliary diseases range from minor infection or scarring to serious conditions such as cancer. At this year’s EASL conference, WuXi AppTec showcased our comprehensive platform of hepatobiliary-related …Read More >

Expanded Role of PDX Models in Anticancer Drug Development Patient-derived xenograft (PDX) models are established by implanting surgically resected patient tumor tissues into immunodeficient mice and have become a pivotal tool in preclinical cancer research due to high clinical-relevance. These models faithfully preserve the original tumor’s molecular, histopathological and pharmacological characteristics, reflecting the heterogeneity and …Read More >

Gout is a common type of inflammatory arthritis linked to abnormal uric acid metabolism, resulting in the accumulation of urate crystal deposits in joints. To support the development of effective gout therapies, precise animal models are needed to properly evaluate drug candidates. At IMMUNOLOGY2024, WuXi AppTec presented a poster highlighting the development of multiple preclinical …Read More >

Atopic dermatitis (AD) is a chronic, pruritic inflammatory skin condition that is characterized by recurrent eczematous lesions. Janus kinase (JAK) inhibitors have been found to be efficacious in treating AD, although their mechanism of action in AD is not fully understood. To support preclinical research in this area, WuXi AppTec presented a poster at IMMUNOLOGY2024 …Read More >

Passive Heymann nephritis, induced by intravenous injection of anti-Fx1A in susceptible rat strains, is a complement-dependent model of glomerular disease that resembles membranous nephropathy in humans.  At IMMUNOLOGY2024, WuXi AppTec presented a poster demonstrating that rapamycin exerts a protective effect against anti-Fx1A-induced passive Heymann nephritis by reducing proteinuria.  The authors show that this antiproteinuric effect …Read More >

Cyclin-dependent kinases (CDKs) and their cyclin regulatory subunits form complexes that are essential for driving abnormal growth processes in cancer cells.  Although CDK4/6 inhibitors have shown promising results in the clinic, acquired resistance to these therapies is frequently observed. The successful development of next generation therapeutics necessitates a better understanding of the mechanisms underlying this …Read More >