Resources Archive - WuXi Biology

Integrated Strategies for Advancing CNS Drug Development

CNS drug development remains one of the most complex challenges in biopharmaceutical research—from target validation and brain exposure to translational...

T-Cell Engagers: Integrated Workflow to Advance TCE Candidates

T-cell engagers (TCEs) are designed to redirect T cells toward tumor cells, offering a highly focused approach to immune-mediated killing....

In Vivo CAR-T: An Integrated Framework

In Vivo CAR-T: An Integrated Framework from Preclinical Development to Clinical Bioanalysis Opportunities and Challenges in In Vivo CAR-T Development...

Simultaneous In Vitro Profiling of Anticancer Efficacy and Toxicity

Many oncology drug candidates with promising preclinical activity ultimately fail because safety liabilities emerge too late in development. An integrated...

EpCAM-CD3 BsAb-Encoding mRNA Suppresses Lung Tumors

Bispecific antibodies have emerged as an important modality in oncology, although their broader application can be limited by manufacturing complexity...

Synthetic-Lethality Screening with PARP1 inhibition

PARP1 plays a central role in DNA repair and is a well-established target across multiple cancer types. Understanding the vulnerabilities...

In Vitro and In Vivo Efficacy of CAR-T Delivery

Targeted lipid nanoparticles (tLNPs) are advancing in vivo CAR-T therapies by facilitating the in situ generation of CAR-T effectors, offering...

In Vivo Evaluation of VEGF-Targeted Bispecific Antibodies

As PD-1/PD-L1 x VEGF-targeted bispecific antibodies gain momentum in oncology, selecting the right preclinical models is becoming increasingly important. These...

Drug-Resistant KRAS G12D Lung Cancer Models

KRAS G12D inhibitors continue to advance, but treatment resistance remains an important challenge. Understanding how that resistance develops is critical...

Knowledge Library