Oligonucleotide Services

Choose excellence, choose WuXi Biology- your reliable partner in oligonucleotide drug discovery. WuXi Biology provides an integrated service platform for support of the discovery of oligonucleotide drugs. Our services cover sequence and modification design of oligonucleotides, in vitro and in vivo biological and PK/PD evaluations, and assessment of oligonucleotide off-target effects. Our broad and deep expertise spans cross diverse oligonucleotide modalities, including siRNAs, Gapmers ASOs, splicing-switch ASOs and mRNAs. We have supported multiple projects for oligonucleotide drug discovery as well as more than 14 IND projects since 2021.

View our platform of oligonucleotide services by clicking HERE.

Sequence design and chemical synthesis

In vitro evaluation of stability and efficacy

Cell lines

  • 1500+ cell lines and patient-derived fibroblasts
  • Customized stable cell lines available

Primary cells

  • Primary hepatocytes of human, mouse, rat, dog and monkey
  • Customized primary cells available

Reporter cell lines

  • ASO splicing reporter
  • psiCHECK

Methods

  • Free uptake
  • Transfection

Additional services include:

  • Stability
  • Entry (binding/uptake) assessment
  • mRNA expression
  • Customized functional assays
  • Protein analysis

In vivo PK/PD assessments

  • Hydrodynamic injection (HDI) mouse model
  • AAV mouse model
  • Transgenic mouse model
  • Cell transplant model

Disease models for functional assessment in mouse and NHPs

  • Neurodegenerative disease
  • Metabolism & liver disease
  • Ophthalmic disease
  • Ear disease
  • Infectious disease

Off-target and safety assessments

  • Cytotoxicity assays
  • In vitro immunogenicity assays
  • Off-target profiling


Oligonucleotide_Platform

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