Case Study: Clinically Relevant NASH Animal Model

In this case study, we demonstrate clinical relevance of the HFD+CCL4 (high-fat diet and carbon tetrachloride) NASH animal model.

Improvement of hepatic fibrosis has been a challenging endpoint in NASH clinical trials and selecting animal models that show anti-fibrotic efficacy has been equally challenging for the preclinical development of new NASH drugs.  Our findings indicate that the in vivo efficacy observed in the HFD+CCL4 model is reflective of clinical outcome, since the extra fibrosis induced in this model is related to NASH clinical observations.  

Check out our platform of liver disease models

View more details on our NASH/NAFLD models

Clinically Relevant NASH Animal Model_case study


← Return to Resources
× peptide, amino acid

Contact An Expert Today!