Knowledge Library

Clinical Drug Resistant PDX Models

An inevitable challenge emerges over time as tumors develop drug resistance, resulting in treatment failure.  The development of targeted therapies for overcoming drug resistance represents an unmet medical need. Patient-derived xenografts (PDXs) represent a powerful platform for cancer drug screening and biomarker discovery and are considered the gold standard of in vivo models for their …Read More >

Resource Type: Latest Science, Presentation
Resource Topic: Oncology, Tumor Models

VIEW

OncoWuXi Express: Efficacy of DLL3 CAR-T in SHP-77 Tumor Models

OncoWuXi Express: Evaluation of DLL3 CAR-T in SHP-77-Luc Tumor Models  Introduction: OncoWuXi Express will continue to keep you informed about updates to our online tumor model database (OncoWuXi Database), as well as our recent progress in cancer and autoimmune research. In this issue, we showcase our DLL3 CAR-T cell preparation and evaluation of their anti-tumor …Read More >

Resource Type: Article, Blog
Resource Topic: CAR-T Cell, Oncology, Tumor Models

VIEW

Accelerating GPCR Drug Discovery and Development

GPCRs: Function, Structure, and Classifications G protein-coupled receptors (GPCRs) are a prevalent class of transmembrane proteins in animal cells, representing one of the largest families of membrane proteins in mammals. These receptors are widely distributed across numerous organs and regulate physiological functions by stimulating intracellular signaling pathways, thereby influencing cellular behavior. GPCRs have a central …Read More >

Resource Type: Article, Blog
Resource Topic: Biochemical Assays, Cell-based Assays, Hit-to-Lead, in vitro biology

VIEW

Protein Science Platform

Benefiting from 15 years of expertise in protein production, the protein science platform within WuXi Biology has successfully served hundreds of global clients. Our protein science specialists are at the forefront of drug discovery efforts, offering a wide range of services including protein production, isotope labeling, and customized conjugation across all major target classes. We …Read More >

Resource Type: Brochure, Case Study
Resource Topic: Cells and Protein Science

VIEW

Creating a Biological Switch Using DEL Technology

In addition to identifying chemical starting points for early drug discovery processes, DNA-encoded library (DEL) technology has now expanded to new applications, including the discovery of bifunctional affinity ligands historically considered difficult to develop. At the 2024 Gordon Research Conference, WuXi AppTec presented a poster describing how DEL can enable the rapid discovery of novel …Read More >

Resource Type: Latest Science, Poster
Resource Topic: Biochemical Assays, CAR-T Cell, Cell-based Assays, DNA-Encoded Library (DEL), Hit Finding

VIEW

Combating Drug Resistance in Cancer Therapy

An inevitable challenge emerges over time as tumors develop drug resistance, resulting in treatment failure. This resistance is inherent to the tumor cells themselves, as well as tied to factors within the tumor microenvironment (TME). To bolster the research of innovative cancer drugs and to emulate real-world clinical scenarios of tumor resistance, WuXi Biology has …Read More >

Resource Type: Video
Resource Topic: Oncology, Tumor Models

VIEW

OncoWuXi Express: Paclitaxel-Induced Resistant Tumor Models

Introduction: OncoWuXi Express will continue to keep you informed about updates to our online tumor model database (OncoWuXi Database), as well as our recent progress in cancer and autoimmune research. In this issue, we would like to share with you the newly established paclitaxel resistant HGC27 and HCC1806 tumor models. https://onco.wuxiapptec.com Paclitaxel, known for its …Read More >

Resource Type: Article, Blog
Resource Topic: Oncology, Tumor Models

VIEW

Recent Insights into Immuno-Oncology

The efficacy of CAR-T therapy is substantially influenced by the tumor microenvironment. This is particularly evident when PD-L1 is activated through CAR-T, leading to the inhibition of CAR-T cell activity via the PD-1 pathway. At the 2024 Recent Insights into Immuno-Oncology Conference, WuXi AppTec presented a poster describing an engineered CAR-T therapy that targets mesothelin …Read More >

Resource Type: Latest Science, Poster
Resource Topic: CAR-T Cell, Oncology

VIEW

Integrated Assay Platform Targeting HMPV Infection

Human metapneumovirus (HMPV) is a common cause of respiratory tract infections in young children, older adults, and people with weakened immune systems. HMPV is in the Pneumoviridae family along with the more commonly known respiratory syncytial virus (RSV).  Currently, there is no specific antiviral therapy to treat HMPV and no vaccine to prevent HMPV. At …Read More >

Resource Type: Latest Science, Poster
Resource Topic: Infectious Diseases, Respiratory Diseases

VIEW


Resource Topics
× peptide, amino acid

Contact An Expert Today!