Knowledge Library

Production and Characterization of Protein Biologics

At the 2024 Protein & Antibody Engineering Summit (PEGS) Europe, Crelux presented a poster highlighting its drug discovery platform for the production and characterization of protein biologics and their antigens. This platform combines construct and expression scouting, customizable high-throughput protein purification, and affinity/kinetics determination using various biophysical techniques, as well as paratope and epitope mapping …Read More >

Resource Type: Latest Science, Poster
Resource Topic: Biophysical Assays, Cells and Protein Science, Cryo-EM, Structural Biology, X-ray Crystallography

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Discovery of GuaB Inhibitors for the Treatment of Tuberculosis

Tuberculosis is the leading cause of death from an infectious disease and is caused by Mycobacterium tuberculosis (MTB). Inosine-5′-monophosphate dehydrogenase (GuaB) is an enzyme that performs the rate-limiting step in the de novo biosynthesis of guanine, which is critical for growth of bacteria, including MTB. The development of a novel antibiotic that inhibits GuaB could …Read More >

Resource Type: Latest Science, Publication
Resource Topic: Discovery Chemistry, Hit Finding, Hit-to-Lead, Infectious Diseases

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OncoWuXi Express: Evaluation of T Cell Engagers

Introduction: OncoWuXi Express will continue to keep you informed about updates to our online tumor model database (OncoWuXi Database), as well as our recent progress in cancer and autoimmune research. In this issue, we would like to share with you our preclinical pharmacological evaluation platform for T cell engagers. https://onco.wuxiapptec.com Introduction T-cell engagers (TCEs) are …Read More >

Resource Type: Article, Blog
Resource Topic: Immunology, in vivo Pharmacology, Oncology

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Metabolic Disease Services Platform

Metabolic diseases are considered to arise from multiple factors (such as genetics, diet, age, and environmental factors) and often affect various organs throughout the body.  No single cause is solely responsible for these disorders. To support research in this area, WuXi AppTec offers a comprehensive platform of in vitro and in vivo services.  Our capabilities …Read More >

Resource Type: Brochure
Resource Topic: Metabolic Diseases

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Small Molecule Reactivator of p53 Y220C Mutant

Mutant p53 is one of the most attractive targets for new anti-cancer drugs. Although traditionally regarded as difficult to drug, several new strategies have recently become available for targeting the mutant protein. One of the most promising of these involves the use of low molecular weight compounds that promote refolding and reactivation of mutant p53 …Read More >

Resource Type: Latest Science, Publication
Resource Topic: Discovery Chemistry, Hit-to-Lead, Lead Optimization, Oncology, Small Molecules

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BaF3 Models Carrying HER2 Mutations

Frequently observed in NSCLC patients, the 4 amino acid YVMA insertion is the most common type of HER2 exon 20 insertion mutation. A secondary mutation, C805S, often develops as a mechanism of resistance to HER2 tyrosine kinase inhibitors (TKIs) such as poziotinib, where the C805 residue is crucial for drug binding.  The presence of a …Read More >

Resource Type: Latest Science, Presentation
Resource Topic: in vivo Pharmacology, Oncology

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Imiquimod-induced Psoriasis-like Dermatitis in NHP

Psoriasis is a chronic autoimmune skin disease characterized by abnormal keratinocyte proliferation and infiltration of inflammatory cells.  The absence of a suitable animal model that accurately mimics the complex phenotype of psoriasis in humans has hindered the development of promising therapeutics to treat this condition. At SITC 2024, WuXi AppTec presented a poster showcasing the …Read More >

Resource Type: Latest Science, Poster
Resource Topic: Autoimmune and Inflammatory Diseases, in vivo Pharmacology

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NLRP3 Inhibitor Reverses Melanoma-Induced Vitiligo

Vitiligo is an autoimmune disorder characterized by the progressive destruction of melanocytes in the skin. This condition is driven by the infiltration of endogenous autoreactive CD8+ T cells, which target and destroy melanocytes, resulting in the clinical manifestation of skin depigmentation. As a common acquired skin disease with no highly effective treatments, there is an …Read More >

Resource Type: Latest Science, Poster
Resource Topic: Autoimmune and Inflammatory Diseases, in vivo Pharmacology

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DELvision: A Protein-DEL Interaction Database

Currently, there is a lack of efficient experimental strategies to collect high-quality proteome level data for protein-ligand interactions (PLIs).  At the 2024 ML Drug Discovery Symposium, WuXi AppTec presented a poster showcasing our advanced DELvision database, representing the first use of DNA-encoded library (DEL) technology for establishing a protein-DEL interaction database. The authors demonstrate how …Read More >

Resource Type: Latest Science, Poster
Resource Topic: DNA-Encoded Library (DEL), in silico services

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Resource Topics
× peptide, amino acid

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