WuXi AppTec offers a comprehensive drug discovery platform to help CNS project teams overcome the challenges in predicting the efficacy and safety of their lead candidates. Our discovery neurobiology platform comprises a wide range of in vitro assays and in vivo animal models.
In vitro services include a β-amyloid peptide aggregation assay, neurite outgrowth assays in primary and iPSC-derived neurons, and an astrocyte/microglial activation assay. Our in vivo platform includes Alzheimer’s models such as the APP/PS1 double transgenic model, and the 5xFAD transgenic mouse model. Parkinson’s animal models offered in our CNS platform include a unilateral 6-OHDA-induced lesion model, and an L-DOPA-induced dyskinesia model.
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