Developing drug-induced resistant tumor models for efficacy evaluation of next-generation anticancer therapies

The therapeutic landscape of cancer has been transformed over the last few decades. Our understanding of cancer and its therapeutic...

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Developing a panel of orthotopic syngeneic tumor models for IO drug discovery

The efficacy of immuno-oncology therapies needs to be evaluated in animal models with functional immune systems. Syngeneic tumor models are...

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Development of an integrated in vitro and in vivo OVA-specific system for cancer vaccine discovery

We have established an advanced and integrated in vitro and in vivo platform for various types of cancer vaccines, including...

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Mouse hind limb tumor metastatic model to evaluate prophylaxis and treatment

We have established and optimized a robust tumor bone metastasis mouse model, which recapitulates the tumor metastasis progression from circulation...

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Evaluating cancer therapies combining radiotherapy with immunotherapy or inhibitors of the DNA damage response

Ionizing radiation has largely been recognized as a local targeted therapy by a variety of mechanisms, including inducing direct DNA...

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Evaluation of the efficacy of ADC in vitro and in vivo

Abstract Antibody drug conjugates (ADCs) are promising complexes with therapeutic potential that aimed to the treatment of solid tumor and...

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WuXi Discovery Services Newsletter: March 2021

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Immuno-Oncology Platform to Enable Discovery from Target to Drug

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Aug 2021: Wuxi AppTec immune profiling in drug discovery and CLDN18.2-related tumor models.

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